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Found 2 Enz. Inhib. hit(s) with Target = 'Presenilin-1' and Ligand = 'BDBM50521244'
TargetPresenilin-1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50521244(CHEMBL4525398)
Affinity DataIC50:  11nMAssay Description:Modulation of gamma secretase in human H4 cells overexpressing human APP695 harboring K595N/M596L Swedish double mutant assessed as reduction in tota...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50521244(CHEMBL4525398)
Affinity DataEC50:  0.0117nMAssay Description:Inhibition of gamma-secretase (unknown origin) assessed as decrease in amyloid beta-42 secretion by cell based AlphaLisa assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed