Compile Data Set for Download or QSAR
Report error Found 25 Enz. Inhib. hit(s) with Target = 'Prostaglandin G/H synthase 1' and Ligand = 'BDBM50029593'
TargetProstaglandin G/H synthase 1(Mouse)
Yeungnam University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50029593BDBM50029593(CHEMBL7162 | NS398 | NS-398 | N-(2-Cyclohexyloxy-4...)
Affinity DataIC50: 1.67E+3nMAssay Description:Inhibitory activity against Prostaglandin G/H synthase 1 in miceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50029593BDBM50029593(CHEMBL7162 | NS398 | NS-398 | N-(2-Cyclohexyloxy-4...)
Affinity DataIC50: 3.00E+3nMAssay Description:The compound was evaluated for its inhibitory activity against Prostaglandin G/H synthase 1 using monocytes-like cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50029593BDBM50029593(CHEMBL7162 | NS398 | NS-398 | N-(2-Cyclohexyloxy-4...)
Affinity DataIC50: 3.30E+3nMAssay Description:IC50 against Prostaglandin G/H synthase 1 from human platelet rich plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50029593BDBM50029593(CHEMBL7162 | NS398 | NS-398 | N-(2-Cyclohexyloxy-4...)
Affinity DataIC50: 3.30E+3nMAssay Description:IC50 value against Prostaglandin G/H synthase 1 of human platelet rich plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50029593BDBM50029593(CHEMBL7162 | NS398 | NS-398 | N-(2-Cyclohexyloxy-4...)
Affinity DataKi:  6.90E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50029593BDBM50029593(CHEMBL7162 | NS398 | NS-398 | N-(2-Cyclohexyloxy-4...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50029593BDBM50029593(CHEMBL7162 | NS398 | NS-398 | N-(2-Cyclohexyloxy-4...)
Affinity DataIC50: 1.00E+4nMAssay Description:Tested for inhibition against Prostaglandin G/H synthase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Universitat De Barcelona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50029593BDBM50029593(CHEMBL7162 | NS398 | NS-398 | N-(2-Cyclohexyloxy-4...)
Affinity DataIC50: 1.41E+4nMAssay Description:Inhibition of sheep COX1 by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50029593BDBM50029593(CHEMBL7162 | NS398 | NS-398 | N-(2-Cyclohexyloxy-4...)
Affinity DataIC50: 2.00E+4nMAssay Description:IC50 value against ovine Prostaglandin G/H synthase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50029593BDBM50029593(CHEMBL7162 | NS398 | NS-398 | N-(2-Cyclohexyloxy-4...)
Affinity DataIC50: 2.00E+4nMAssay Description:IC50 against ovine Prostaglandin G/H synthase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50029593BDBM50029593(CHEMBL7162 | NS398 | NS-398 | N-(2-Cyclohexyloxy-4...)
Affinity DataIC50: 3.57E+4nMAssay Description:Inhibition of COX1 in human whole blood assessed as effect on A-23187-stimulated TxB2 productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Universitat De Barcelona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50029593BDBM50029593(CHEMBL7162 | NS398 | NS-398 | N-(2-Cyclohexyloxy-4...)
Affinity DataIC50: 3.70E+4nMAssay Description:In vitro inhibitory activity against Prostaglandin G/H synthase 1 in sheepMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Mouse)
Yeungnam University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50029593BDBM50029593(CHEMBL7162 | NS398 | NS-398 | N-(2-Cyclohexyloxy-4...)
Affinity DataIC50: 6.37E+4nMAssay Description:Inhibition of COX1 in mouse RAW264.7 cells by enzyme immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Universitat De Barcelona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50029593BDBM50029593(CHEMBL7162 | NS398 | NS-398 | N-(2-Cyclohexyloxy-4...)
Affinity DataIC50: 6.60E+4nMAssay Description:Inhibition of the ovine Prostaglandin G/H synthase 1 was determined by thin-layer chromatography assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Bovine)
Uppsala University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50029593BDBM50029593(CHEMBL7162 | NS398 | NS-398 | N-(2-Cyclohexyloxy-4...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of bovine seminal microsomal COX1 assessed as PGE2 production preincubated for 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50029593BDBM50029593(CHEMBL7162 | NS398 | NS-398 | N-(2-Cyclohexyloxy-4...)
Affinity DataIC50: 1.00E+5nMAssay Description:In vitro inhibitory activity against constitutive form of human recombinant cyclooxygenase (COX-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetProstaglandin G/H synthase 1(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50029593BDBM50029593(CHEMBL7162 | NS398 | NS-398 | N-(2-Cyclohexyloxy-4...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of COX1-catalyzed prostaglandin biosynthesis 10 mins of preincubationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50029593BDBM50029593(CHEMBL7162 | NS398 | NS-398 | N-(2-Cyclohexyloxy-4...)
Affinity DataIC50: 1.00E+5nMAssay Description:In vitro inhibition of prostaglandin G/H synthase 1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Universitat De Barcelona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50029593BDBM50029593(CHEMBL7162 | NS398 | NS-398 | N-(2-Cyclohexyloxy-4...)
Affinity DataIC50: 2.05E+5nMAssay Description:Inhibition of ovine COX1 assessed as inhibition of PGF2alpha production from PGH2 by enzyme immuno assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Universitat De Barcelona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50029593BDBM50029593(CHEMBL7162 | NS398 | NS-398 | N-(2-Cyclohexyloxy-4...)
Affinity DataIC50: 2.13E+5nMAssay Description:Inhibition of ovine recombinant COX-1 using PGH2 as substrate incubated for 10 mins prior to arachidonic acid addition measured after 2 mins by EIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2016
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Universitat De Barcelona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50029593BDBM50029593(CHEMBL7162 | NS398 | NS-398 | N-(2-Cyclohexyloxy-4...)
Affinity DataIC50: 2.13E+5nMAssay Description:Inhibition of ovine COX1 assessed as prostaglandin F2alpha levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Universitat De Barcelona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50029593BDBM50029593(CHEMBL7162 | NS398 | NS-398 | N-(2-Cyclohexyloxy-4...)
Affinity DataIC50: 2.13E+5nMpH: 8.0 T: 2°CAssay Description:Reaction mixtures were prepared in 100 mM Tris HCl buffer, pH 8.0 containing 1 µM heme and COX-1 or COX-2 and preincubated for 10 min in a waterbath ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2015
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Laboratoires Innothera

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50029593BDBM50029593(CHEMBL7162 | NS398 | NS-398 | N-(2-Cyclohexyloxy-4...)
Affinity DataIC50: 2.20E+5nMAssay Description:Inhibition of COX1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2016
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Universitat De Barcelona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50029593BDBM50029593(CHEMBL7162 | NS398 | NS-398 | N-(2-Cyclohexyloxy-4...)
Affinity DataIC50: 2.20E+5nMAssay Description:Inhibition of ovine COX-1 assessed as decrease in PGH2 production using arachidonic acid as substrate treated with enzyme for 10 mins prior to substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Universitat De Barcelona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50029593BDBM50029593(CHEMBL7162 | NS398 | NS-398 | N-(2-Cyclohexyloxy-4...)
Affinity DataIC50: 2.20E+5nMAssay Description:Inhibition of ovine COX1 by enzyme immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2018
Entry Details Article
PubMed