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Found 16 Enz. Inhib. hit(s) with Target = 'Prostaglandin G/H synthase 1' and Ligand = 'BDBM50029600'
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50029600(5-Bromo-2-(4-fluoro-phenyl)-3-(4-methanesulfonyl-p...)
Affinity DataIC50:  7nMAssay Description:Inhibition of Prostaglandin G/H synthase 1 was measured by the inhibition of PGE-2 produced by microsomes from U937 cells at subsaturating arachidoni...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
University Of Hacettepe

Curated by ChEMBL
LigandPNGBDBM50029600(5-Bromo-2-(4-fluoro-phenyl)-3-(4-methanesulfonyl-p...)
Affinity DataIC50:  41.6nMAssay Description:Inhibition of ovine COX1 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50029600(5-Bromo-2-(4-fluoro-phenyl)-3-(4-methanesulfonyl-p...)
Affinity DataIC50:  59nMAssay Description:Inhibition of PGE-2 production in arachidonic acid-stimulated CHO cells expressing human Prostaglandin G/H synthase 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50029600(5-Bromo-2-(4-fluoro-phenyl)-3-(4-methanesulfonyl-p...)
Affinity DataIC50:  59nMAssay Description:Tested in vitro for the ability to inhibit Prostaglandin G/H synthase 1 in chinese hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50029600(5-Bromo-2-(4-fluoro-phenyl)-3-(4-methanesulfonyl-p...)
Affinity DataIC50:  59nMAssay Description:In vitro inhibition of the production of PGE-2 in arachidonic acid stimulated chinese hamster ovary (CHO) cellstransfected with human cyclooxygenase-...More data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50029600(5-Bromo-2-(4-fluoro-phenyl)-3-(4-methanesulfonyl-p...)
Affinity DataIC50:  600nMAssay Description:Inhibitory activity against human COX-1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50029600(5-Bromo-2-(4-fluoro-phenyl)-3-(4-methanesulfonyl-p...)
Affinity DataIC50:  600nMAssay Description:Inhibitory activity of the compound against human recombinant Prostaglandin G/H synthase 1 expressed in microsomes taken from baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50029600(5-Bromo-2-(4-fluoro-phenyl)-3-(4-methanesulfonyl-p...)
Affinity DataIC50:  800nMAssay Description:In vitro inhibition of prostaglandin G/H synthase 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50029600(5-Bromo-2-(4-fluoro-phenyl)-3-(4-methanesulfonyl-p...)
Affinity DataIC50:  810nMAssay Description:Inhibitory activity against human recombinant Prostaglandin G/H synthase 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50029600(5-Bromo-2-(4-fluoro-phenyl)-3-(4-methanesulfonyl-p...)
Affinity DataIC50:  870nMAssay Description:Inhibition of human COX1 expressed in african green monkey COS cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50029600(5-Bromo-2-(4-fluoro-phenyl)-3-(4-methanesulfonyl-p...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of Prostaglandin G/H synthase 1 in human whole blood (HWB) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
University Of Hacettepe

Curated by ChEMBL
LigandPNGBDBM50029600(5-Bromo-2-(4-fluoro-phenyl)-3-(4-methanesulfonyl-p...)
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of ovine COX1 using arachidonic acid as substrate pretreated for 5 mins followed by substrate addition and measured after 2 mins by fluore...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
University Of Hacettepe

Curated by ChEMBL
LigandPNGBDBM50029600(5-Bromo-2-(4-fluoro-phenyl)-3-(4-methanesulfonyl-p...)
Affinity DataIC50:  4.60E+3nMAssay Description:In vitro inhibitory activity against Prostaglandin G/H synthase 1 in sheepMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50029600(5-Bromo-2-(4-fluoro-phenyl)-3-(4-methanesulfonyl-p...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human COX-1 preincubated for 15 mins followed by fluorometric substrate/heme addition for 15 mins subsequently incubated with arachidon...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50029600(5-Bromo-2-(4-fluoro-phenyl)-3-(4-methanesulfonyl-p...)
Affinity DataIC50:  2.26E+4nMAssay Description:Inhibition of COX1 in human platelet microsomes assessed as reduction in formation of oxidized TMPD using arachidonic acid as substrate preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
University Of Hacettepe

Curated by ChEMBL
LigandPNGBDBM50029600(5-Bromo-2-(4-fluoro-phenyl)-3-(4-methanesulfonyl-p...)
Affinity DataIC50:  3.80E+4nMAssay Description:Compound was evaluated for inhibitory activity against ovine Prostaglandin G/H synthase 1More data for this Ligand-Target Pair
In DepthDetails Article