Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) with Target = 'Prostaglandin G/H synthase 2' and Ligand = 'BDBM50339185'
TargetProstaglandin G/H synthase 2(Human)
University of Pennsylvania

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50339185BDBM50339185((2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid | ...)
Affinity DataIC50: 900nMAssay Description:Inhibition of COX2 (unknown origin) using arachidonic acid as substrate assessed as reduction in PGH2 conversion to PGG2 by measuring TMPD oxidation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
University of Pennsylvania

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50339185BDBM50339185((2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid | ...)
Affinity DataIC50: 2.39E+3nMAssay Description:Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition and measured after 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetProstaglandin G/H synthase 2(Sheep)
Universitat De Barcelona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50339185BDBM50339185((2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid | ...)
Affinity DataIC50: 3.36E+3nMAssay Description:Inhibition of ovine COX2 assessed as reduction in PGH2 production by enzyme immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
University of Pennsylvania

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50339185BDBM50339185((2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid | ...)
Affinity DataIC50: 9.70E+3nMAssay Description:Tested for inhibitory activity against Prostaglandin G/H synthase 2 from humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
University of Pennsylvania

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50339185BDBM50339185((2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid | ...)
Affinity DataIC50: 1.01E+4nMAssay Description:Inhibition of COX-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetProstaglandin G/H synthase 2(Human)
University of Pennsylvania

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50339185BDBM50339185((2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid | ...)
Affinity DataIC50: 1.24E+4nMAssay Description:Inhibition of human recombinant COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
University of Pennsylvania

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50339185BDBM50339185((2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid | ...)
Affinity DataIC50: 1.24E+4nMAssay Description:Inhibition of human recombinant COX-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
University of Pennsylvania

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50339185BDBM50339185((2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid | ...)
Affinity DataIC50: 1.89E+4nMAssay Description:Inhibitory activity against prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
University of Pennsylvania

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50339185BDBM50339185((2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid | ...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human recombinant COX-2 by enzyme immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetProstaglandin G/H synthase 2(Human)
University of Pennsylvania

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50339185BDBM50339185((2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid | ...)
Affinity DataIC50: 5.22E+4nMAssay Description:Inhibition of human COX2 expressed in insect cells using arachidonic acid as substrate pretreated for 3 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
University of Pennsylvania

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50339185BDBM50339185((2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid | ...)
Affinity DataIC50: 1.01E+6nMAssay Description:Inhibition of COX2-catalyzed prostaglandin biosynthesis after 10 mins of preincubationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Sheep)
Universitat De Barcelona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50339185BDBM50339185((2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid | ...)
Affinity DataIC50: 1.02E+6nMAssay Description:Inhibition of sheep placental cotyledons COX2 assessed as PGE2 production preincubated for 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed