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Found 3 Enz. Inhib. hit(s) with Target = 'Prostaglandin G/H synthase 2' and Ligand = 'BDBM50361579'
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Rottapharm Biotech

US Patent
LigandPNGBDBM50361579(CHEMBL1939680 | US9162979, 3-II)
Affinity DataIC50:  85nMT: 2°CAssay Description:The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50361579(CHEMBL1939680 | US9162979, 3-II)
Affinity DataIC50:  85nMAssay Description:Inhibition of COX-2-mediated PGE2 production in LPS-stimulated mouse J774 cells after 24 hrs by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Rottapharm Biotech

US Patent
LigandPNGBDBM50361579(CHEMBL1939680 | US9162979, 3-II)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of COX2-mediated PGE2 production in LPS-induced human whole blood after 60 mins by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed