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Found 4 Enz. Inhib. hit(s) with Target = 'Proteinase-activated receptor 2' and Ligand = 'BDBM429572'
TargetProteinase-activated receptor 2(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM429572(US10550089, Example 46 | US10995072, Example 46)
Affinity DataIC50:  2.17E+3nMAssay Description:Inositol monophosphate (IP1) production were measured in 1321N1 cells stably expressing human PAR2 using an IP-One HTRF assay kit (Cisbio). 80 nl of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 2(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM429572(US10550089, Example 46 | US10995072, Example 46)
Affinity DataIC50:  2.17E+3nMAssay Description:Inositol monophosphate (IP1) production were measured in 1321N1 cells stably expressing human PAR2 using an IP-One HTRF assay kit (Cisbio). 80 nl of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 2(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM429572(US10550089, Example 46 | US10995072, Example 46)
Affinity DataIC50:  1.45E+4nMAssay Description:Calcium mobilization was measured using 1321N1 cells stably expressing human PAR2. Cells were seeded in 384-well plates at 4,000 cells per well in 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 2(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM429572(US10550089, Example 46 | US10995072, Example 46)
Affinity DataIC50:  1.45E+4nMAssay Description:Calcium mobilization was measured using 1321N1 cells stably expressing human PAR2. Cells were seeded in 384-well plates at 4,000 cells per well in 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent