Found 9 Enz. Inhib. hit(s) with Target = 'Proto-oncogene tyrosine-protein kinase receptor Ret' and Ligand = 'BDBM50382959' TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Gothenburg
Curated by ChEMBL
University Of Gothenburg
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of human RET kinase using IGF1Rtide as substrate incubated for 40 mins and measured by ADP-Glo assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Gothenburg
Curated by ChEMBL
University Of Gothenburg
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant RET M918T (unknown origin) incubated for 120 mins by Perkin Elmer electrophoretic mobility shift platform methodMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Gothenburg
Curated by ChEMBL
University Of Gothenburg
Curated by ChEMBL
Affinity DataIC50: 4.30nMAssay Description:Inhibition of RET M918T (unknown origin)More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Gothenburg
Curated by ChEMBL
University Of Gothenburg
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of RET (unknown origin) by kinomescan assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Gothenburg
Curated by ChEMBL
University Of Gothenburg
Curated by ChEMBL
Affinity DataIC50: 31nMAssay Description:Inhibition of wildtype RET (unknown origin) incubated for 120 mins by Perkin Elmer electrophoretic mobility shift platform methodMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Gothenburg
Curated by ChEMBL
University Of Gothenburg
Curated by ChEMBL
Affinity DataIC50: 168nMAssay Description:Inhibition of recombinant RET V804L (unknown origin) incubated for 120 mins by Perkin Elmer electrophoretic mobility shift platform methodMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Gothenburg
Curated by ChEMBL
University Of Gothenburg
Curated by ChEMBL
Affinity DataIC50: 319nMAssay Description:Inhibition of RET V804L (unknown origin)More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Gothenburg
Curated by ChEMBL
University Of Gothenburg
Curated by ChEMBL
Affinity DataKd: 2nMAssay Description:Inhibition of Ret in human HEK293 cells after 1 hr by competition binding assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Gothenburg
Curated by ChEMBL
University Of Gothenburg
Curated by ChEMBL
Affinity DataKd: 1.5nMAssay Description:Binding affinity to RET (unknown origin) assessed as dissociation constant measured by ambit kinomescan assayMore data for this Ligand-Target Pair
