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Found 4 Enz. Inhib. hit(s) with Target = 'Receptor-type tyrosine-protein kinase FLT3' and Ligand = 'BDBM112464'
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM112464(US8623885, 5)
Affinity DataIC50:  1nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM112464(US8623885, 5)
Affinity DataIC50:  1nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM112464(US8623885, 5)
Affinity DataIC50:  1.5nMpH: 7.6Assay Description:The FLT3 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a HTRF kinase assay. The FLT3 enzyme (GST-FLT3 fusion) was purchased f...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM112464(US8623885, 5)
Affinity DataKd:  4nMAssay Description:Binding affinity to wild type FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed