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Found 3 Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase PLK1' and Ligand = 'BDBM28165'
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Gsk

LigandPNGBDBM28165(5-(1H-1,3-benzodiazol-1-yl)-3-{[2-(trifluoromethyl...)
Affinity DataIC50:  15nMpH: 7.2 T: 2°CAssay Description:The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Gsk

LigandPNGBDBM28165(5-(1H-1,3-benzodiazol-1-yl)-3-{[2-(trifluoromethyl...)
Affinity DataIC50:  35nMAssay Description:Inhibition of PLK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Gsk

LigandPNGBDBM28165(5-(1H-1,3-benzodiazol-1-yl)-3-{[2-(trifluoromethyl...)
Affinity DataEC50:  2.00E+3nMAssay Description:Inhibition of PLK1-mediated mitosis in human HeLaS3 cells after 18 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed