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Found 4 Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase SIK2' and Ligand = 'BDBM192712'
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM192712(HG-9-91-01 (1))
Affinity DataIC50:  3.5nMpH: 8.0Assay Description:IC50‘s for HG-9-91-01 derivatives were measured by Caliper-based mobility shift assay (PerkinElmer). For these experiments, full length His6-MBP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM192712(HG-9-91-01 (1))
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of SIK2 (unknown origin) assessed as enzyme remaining activity by scanMAX kinase assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM192712(HG-9-91-01 (1))
Affinity DataIC50:  6.60E+3nMAssay Description:Inhibition of GST fused recombinant SIK2 (unknown origin) in human HEK293 cells assessed as effect on CRTC3 phosphorylation at Ser162 incubated for 1...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))
Broad Institute

LigandPNGBDBM192712(HG-9-91-01 (1))
Affinity DataIC50:  5.84E+5nMAssay Description:Inhibition of full length N-terminal nanoLuc-tagged human SIK2 expressed in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 hrs in pres...More data for this Ligand-Target Pair
In DepthDetails PubMed