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Found 4 Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase ULK1' and Ligand = 'BDBM379323'
TargetSerine/threonine-protein kinase ULK1(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM379323(N4-cyclopropyl-N2-(1H-indol-5-yl)-5-(trifluorometh...)
Affinity DataIC50:  23nMAssay Description:Inhibition of recombinant human ULK1 (1-649) expressed in Sf9 cells using myelin basic protein as substrate by ADP-glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase ULK1(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM379323(N4-cyclopropyl-N2-(1H-indol-5-yl)-5-(trifluorometh...)
Affinity DataIC50: <200nMAssay Description:Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase ULK1(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM379323(N4-cyclopropyl-N2-(1H-indol-5-yl)-5-(trifluorometh...)
Affinity DataIC50: <200nMAssay Description:ULK1 inhibition assay is a screening assay to identify compounds that inhibit kinase activity of ULK1 using the ULKtide peptide. In some embodiments,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase ULK1(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM379323(N4-cyclopropyl-N2-(1H-indol-5-yl)-5-(trifluorometh...)
Affinity DataIC50:  9.84E+3nMAssay Description:Inhibition of ULK1 (unknown origin) expressed in HEK293T cells incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed