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Found 3 Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase mTOR' and Ligand = 'BDBM35575'
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35575(pyrazolo pyrimidine, 9)
Affinity DataIC50:  4.60nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35575(pyrazolo pyrimidine, 9)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of human mTOR (1360-2549 amino acids) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35575(pyrazolo pyrimidine, 9)
Affinity DataIC50:  7nMAssay Description:Inhibition of recombinant FLAG-tagged mTOR (unknown origin) expressed in HEK293 cells assessed as decrease in phosphorylation of S6K level at Thr389 ...More data for this Ligand-Target Pair
In DepthDetails PubMed