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Found 6 Enz. Inhib. hit(s) with Target = 'Serine-protein kinase ATM' and Ligand = 'BDBM50550657'
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Charles River

Curated by ChEMBL
LigandPNGBDBM50550657(CHEMBL4792737)
Affinity DataKi:  0.5nMAssay Description:Inhibition of full length recombinant FLAG-tagged human ATM assessed as decrease in p53 S15 phosphorylation using full length myc-tagged p53 as subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Charles River

Curated by ChEMBL
LigandPNGBDBM50550657(CHEMBL4792737)
Affinity DataKi:  0.5nMAssay Description:Inhibition of rat neutrophil 5- Lipoxygenase (5-LO)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Charles River

Curated by ChEMBL
LigandPNGBDBM50550657(CHEMBL4792737)
Affinity DataIC50:  5nMAssay Description:Inhibition of recombinant full-length human FLAG-tagged ATM assessed as reduction in p53 S15 phosphorylation incubated for 30 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Charles River

Curated by ChEMBL
LigandPNGBDBM50550657(CHEMBL4792737)
Affinity DataIC50:  910nMAssay Description:Inhibition of ATM in human MCF7 cells assessed as reduction in etoposide-stimulated KAP1 phosphorylation incubated for 1 hr by ICW assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Charles River

Curated by ChEMBL
LigandPNGBDBM50550657(CHEMBL4792737)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of rat neutrophil 5- Lipoxygenase (5-LO)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Charles River

Curated by ChEMBL
LigandPNGBDBM50550657(CHEMBL4792737)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of ATM in human U2OS cells assessed as reduction in etoposide-stimulated KAP1 phosphorylation incubated for 60 mins by immunoreactivity as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed