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Found 2 Enz. Inhib. hit(s) with Target = 'Smoothened homolog' and Ligand = 'BDBM50320358'
TargetSmoothened homolog(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50320358((R)-(3-methyl-4-(4-phenylphthalazin-1-yl)piperazin...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50320358((R)-(3-methyl-4-(4-phenylphthalazin-1-yl)piperazin...)
Affinity DataIC50:  2.20nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed