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Found 4 Enz. Inhib. hit(s) with Target = 'Sodium-dependent noradrenaline transporter' and Ligand = 'BDBM436576'
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Esteve Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM436576((S)-2-amino-9-methyl- 6-(3-(3-(methylamino)- 1-(th...)
Affinity DataKi:  59nMAssay Description:Displacement of [3H]-nisoxetine from human NET expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Esteve Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM436576((S)-2-amino-9-methyl- 6-(3-(3-(methylamino)- 1-(th...)
Affinity DataKi:  300nMAssay Description:NET: Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer co...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Esteve Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM436576((S)-2-amino-9-methyl- 6-(3-(3-(methylamino)- 1-(th...)
Affinity DataIC50:  7nMAssay Description:Inhibitory activity against dihydrofolate reductase in rat liverMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Esteve Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM436576((S)-2-amino-9-methyl- 6-(3-(3-(methylamino)- 1-(th...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human NET expressed in HEK293 cells assessed as reduction in ASP+ uptake incubated for 20 mins before ASP+ addition and measured after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed