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Found 10 Enz. Inhib. hit(s) with Target = 'Sodium-dependent serotonin transporter' and Ligand = 'BDBM50006774'
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50006774((2S,3S)-methyl 3-(4-iodophenyl)-8-methyl-8-aza-bic...)
Affinity DataKi:  0.380nMAssay Description:Displacement of [3H]paroxetine from 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50006774((2S,3S)-methyl 3-(4-iodophenyl)-8-methyl-8-aza-bic...)
Affinity DataKi:  0.410nMAssay Description:Binding affinity to serotonin transporter (SERT) in rat forebrain tissueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50006774((2S,3S)-methyl 3-(4-iodophenyl)-8-methyl-8-aza-bic...)
Affinity DataKi:  0.460nMAssay Description:Affinity for Serotonin transporter by displacing [3H]-Paroxetine from rat forebrainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50006774((2S,3S)-methyl 3-(4-iodophenyl)-8-methyl-8-aza-bic...)
Affinity DataKi:  0.460nMAssay Description:Ability to displace [3H]- paroxetine from Serotonin transporter in rat cerebral cortical homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50006774((2S,3S)-methyl 3-(4-iodophenyl)-8-methyl-8-aza-bic...)
Affinity DataKi:  0.670nMAssay Description:In vitro competitive binding versus [3H]-citalopram in murine kidney cells transfected with cDNA for human serotonin transporter (SERT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50006774((2S,3S)-methyl 3-(4-iodophenyl)-8-methyl-8-aza-bic...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]- paroxetine from serotonin transporter (5-HTT) in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50006774((2S,3S)-methyl 3-(4-iodophenyl)-8-methyl-8-aza-bic...)
Affinity DataIC50:  3.80nMAssay Description:Compound was tested for binding affinity to Serotonin transporter sites in homogenates prepared from rat cortical membranes using [3H]paroxetine as r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50006774((2S,3S)-methyl 3-(4-iodophenyl)-8-methyl-8-aza-bic...)
Affinity DataIC50:  4.20nMAssay Description:Binding affinity towards serotonin transporter (SERT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50006774((2S,3S)-methyl 3-(4-iodophenyl)-8-methyl-8-aza-bic...)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of [3H]paroxetine binding to Serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50006774((2S,3S)-methyl 3-(4-iodophenyl)-8-methyl-8-aza-bic...)
Affinity DataIC50:  4.21nMAssay Description:Displacement of [3H]paroxetine from 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed