Found 4 Enz. Inhib. hit(s) with Target = 'Sphingosine 1-phosphate receptor 1' and Ligand = 'BDBM50562873' TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.0400nMAssay Description:Displacement of [33P]-SIP from human recombinant S1P1 expressed in CHO cell membranes measured after 45 mins by TopCount scintillation counting metho...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataEC50: 0.400nMAssay Description:Agonist activity at human recombinant C-terminal GFP-fused S1P1 expressed in CHO cells assessed as induction of receptor internalization incubated fo...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataEC50: 2.10nMAssay Description:Agonist activity at recombinant human S1P1 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins ...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataEC50: 5.20nMAssay Description:Agonist activity at human recombinant S1P1 expressed in CHO cells assessed as stimulation of ERK phosphorylation incubated for 7 mins by microplate r...More data for this Ligand-Target Pair
