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Found 8 Enz. Inhib. hit(s) with Target = 'Sphingosine 1-phosphate receptor 4' and Ligand = 'BDBM23163'
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM23163(CHEMBL114606 | FTY720-phosphate, rac-2 | {2-amino-...)
Affinity DataKi:  37nM ΔG°:  -39.4kJ/molepH: 7.5 T: 2°CAssay Description:Ki Values were determined by competition of [32P]-S1P binding to stably transfected CHO (S1P1,2,4) or RH7777 (S1P3,5) cells expressing the indicated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM23163(CHEMBL114606 | FTY720-phosphate, rac-2 | {2-amino-...)
Affinity DataIC50:  15nMAssay Description:Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM23163(CHEMBL114606 | FTY720-phosphate, rac-2 | {2-amino-...)
Affinity DataIC50:  15nMAssay Description:Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM23163(CHEMBL114606 | FTY720-phosphate, rac-2 | {2-amino-...)
Affinity DataEC50:  41nMAssay Description:Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM23163(CHEMBL114606 | FTY720-phosphate, rac-2 | {2-amino-...)
Affinity DataEC50:  0.0900nMAssay Description:Agonist activity at human S1P4 receptor by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM23163(CHEMBL114606 | FTY720-phosphate, rac-2 | {2-amino-...)
Affinity DataEC50:  4nMAssay Description:Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM23163(CHEMBL114606 | FTY720-phosphate, rac-2 | {2-amino-...)
Affinity DataEC50:  1.60nMAssay Description:Agonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM23163(CHEMBL114606 | FTY720-phosphate, rac-2 | {2-amino-...)
Affinity DataEC50:  2.40nMpH: 7.4Assay Description:Agonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]-GTP-gammaS as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed