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Found 9 Enz. Inhib. hit(s) with Target = 'Sphingosine kinase 1' and Ligand = 'BDBM50443388'
TargetSphingosine kinase 1(Homo sapiens (Human))
The City University Of New York

Curated by ChEMBL
LigandPNGBDBM50443388(CHEMBL3086782 | US9688668, SLR080811)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of sphingosine kinase 1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
The City University Of New York

Curated by ChEMBL
LigandPNGBDBM50443388(CHEMBL3086782 | US9688668, SLR080811)
Affinity DataKi: >1.00E+4nMAssay Description:SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSphingosine kinase 1(Homo sapiens (Human))
The City University Of New York

Curated by ChEMBL
LigandPNGBDBM50443388(CHEMBL3086782 | US9688668, SLR080811)
Affinity DataKi: >1.00E+4nMAssay Description:SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSphingosine kinase 1(Homo sapiens (Human))
The City University Of New York

Curated by ChEMBL
LigandPNGBDBM50443388(CHEMBL3086782 | US9688668, SLR080811)
Affinity DataKi:  1.20E+4nMAssay Description:Functional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
The City University Of New York

Curated by ChEMBL
LigandPNGBDBM50443388(CHEMBL3086782 | US9688668, SLR080811)
Affinity DataKi:  1.20E+4nMAssay Description:Inhibition of recombinant SK1 (unknown origin) expressed in Sf9 insect cells using D-erythro-sphingosine as substrate measured in presence of [gamma3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
The City University Of New York

Curated by ChEMBL
LigandPNGBDBM50443388(CHEMBL3086782 | US9688668, SLR080811)
Affinity DataKi:  1.20E+4nMAssay Description:SLR080811, prepared as the HCl salt, was tested first at recombinant SphK1 and SphK2 using a broken cell assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSphingosine kinase 1(Homo sapiens (Human))
The City University Of New York

Curated by ChEMBL
LigandPNGBDBM50443388(CHEMBL3086782 | US9688668, SLR080811)
Affinity DataKi:  1.30E+4nMAssay Description:Inhibition of human recombinant SphK1 expressed in Sf9 cells assessed as radiolabeled products using 5 uM sphingosine and 10 uM gamma[32P]ATP by liqu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
The City University Of New York

Curated by ChEMBL
LigandPNGBDBM50443388(CHEMBL3086782 | US9688668, SLR080811)
Affinity DataKi:  1.33E+4nMAssay Description:Inhibition of SphK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
The City University Of New York

Curated by ChEMBL
LigandPNGBDBM50443388(CHEMBL3086782 | US9688668, SLR080811)
Affinity DataKi:  1.60E+4nMAssay Description:Inhibition of human recombinant SphK1 using sphingosine as substrate incubated for 20 mins by scintillation counting analysis in presence of [gamma-3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed