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Found 4 Enz. Inhib. hit(s) with Target = 'Thymidylate synthase' and Ligand = 'BDBM18766'
TargetThymidylate synthase(Escherichia coli)
Unimore

LigandPNGBDBM18766(1,8-naphthalein derivative, 13 | 4-(3-bromo-4-hydr...)
Affinity DataKi:  400nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Lactobacillus casei)
Unimore

LigandPNGBDBM18766(1,8-naphthalein derivative, 13 | 4-(3-bromo-4-hydr...)
Affinity DataKi:  1.00E+3nM ΔG°:  -33.7kJ/molepH: 7.4 T: 2°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Cryptococcus neoformans)
Unimore

LigandPNGBDBM18766(1,8-naphthalein derivative, 13 | 4-(3-bromo-4-hydr...)
Affinity DataKi:  5.20E+3nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Unimore

LigandPNGBDBM18766(1,8-naphthalein derivative, 13 | 4-(3-bromo-4-hydr...)
Affinity DataKi: >1.32E+5nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed