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Found 8 Enz. Inhib. hit(s) with Target = 'Thymidylate synthase' and Ligand = 'BDBM18770'
TargetThymidylate synthase(Escherichia coli)
Unimore

LigandPNGBDBM18770(1,8-naphthalein derivative, 18 | 8-chloro-4,4-bis(...)
Affinity DataKi:  1.10E+3nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Unimore

LigandPNGBDBM18770(1,8-naphthalein derivative, 18 | 8-chloro-4,4-bis(...)
Affinity DataKi:  1.10E+3nM ΔG°:  -33.4kJ/molepH: 7.0 T: 2°CAssay Description:The inhibition assay pattern for all of the compounds was determined by steady-state kinetic analysis of the dependence of the TS enzyme activity on ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Lactobacillus casei)
Unimore

LigandPNGBDBM18770(1,8-naphthalein derivative, 18 | 8-chloro-4,4-bis(...)
Affinity DataKi:  1.80E+3nM ΔG°:  -32.2kJ/molepH: 7.4 T: 2°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Lactobacillus casei)
Unimore

LigandPNGBDBM18770(1,8-naphthalein derivative, 18 | 8-chloro-4,4-bis(...)
Affinity DataKi:  1.80E+3nM ΔG°:  -32.2kJ/molepH: 7.0 T: 2°CAssay Description:The inhibition assay pattern for all of the compounds was determined by steady-state kinetic analysis of the dependence of the TS enzyme activity on ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Cryptococcus neoformans)
Unimore

LigandPNGBDBM18770(1,8-naphthalein derivative, 18 | 8-chloro-4,4-bis(...)
Affinity DataKi:  6.50E+3nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Pneumocystis carinii)
UniversitÀ

LigandPNGBDBM18770(1,8-naphthalein derivative, 18 | 8-chloro-4,4-bis(...)
Affinity DataKi:  2.20E+4nM ΔG°:  -26.1kJ/molepH: 7.0 T: 2°CAssay Description:The inhibition assay pattern for all of the compounds was determined by steady-state kinetic analysis of the dependence of the TS enzyme activity on ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
UniversitÀ

LigandPNGBDBM18770(1,8-naphthalein derivative, 18 | 8-chloro-4,4-bis(...)
Affinity DataKi: >2.45E+5nM ΔG°: >-20.3kJ/molepH: 7.0 T: 2°CAssay Description:The inhibition assay pattern for all of the compounds was determined by steady-state kinetic analysis of the dependence of the TS enzyme activity on ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
UniversitÀ

LigandPNGBDBM18770(1,8-naphthalein derivative, 18 | 8-chloro-4,4-bis(...)
Affinity DataKi: >2.45E+5nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed