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Found 4 Enz. Inhib. hit(s) with Target = 'Thyroid peroxidase' and Ligand = 'BDBM312173'
TargetThyroid peroxidase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM312173(1-{2-[(1S)-1-Aminoethyl]-4-chlorobenzyl}-2-thioxo-...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human recombinant TPO (1 to 839 residues) expressed in baculovirus-infected insect cells measured after 15 mins in presence of H2O2 by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetThyroid peroxidase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM312173(1-{2-[(1S)-1-Aminoethyl]-4-chlorobenzyl}-2-thioxo-...)
Affinity DataIC50:  6.80E+4nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThyroid peroxidase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM312173(1-{2-[(1S)-1-Aminoethyl]-4-chlorobenzyl}-2-thioxo-...)
Affinity DataIC50:  6.80E+4nMAssay Description:To detect thyroid peroxidase (TPO) inhibitory activity, the production of hypoiodous acid (HOI) was quantified. HOI was detected by reacting it with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThyroid peroxidase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM312173(1-{2-[(1S)-1-Aminoethyl]-4-chlorobenzyl}-2-thioxo-...)
Affinity DataIC50:  6.80E+4nMAssay Description:MPO: The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent