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Found 3 Enz. Inhib. hit(s) with Target = 'Transthyretin' and Ligand = 'BDBM22971'
TargetTransthyretin(Homo sapiens (Human))
Leland Stanford Junior University

US Patent
LigandPNGBDBM22971(2-[(2,6-dichloro-3-methylphenyl)amino]benzoic acid...)
Affinity DataIC50:  504nMAssay Description:Table 3: The FP assay was then adapted for HTS and used to screen 120,000 small molecule library for compounds that displaced probe 5 from the T4 bin...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransthyretin(Homo sapiens (Human))
Leland Stanford Junior University

US Patent
LigandPNGBDBM22971(2-[(2,6-dichloro-3-methylphenyl)amino]benzoic acid...)
Affinity DataIC50:  5.00E+4nMAssay Description:Binding affinity to TTR in human plasma assessed as protein stabilization preincubated for 1 hr followed by urea-mediated denaturation by Western blo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Leland Stanford Junior University

US Patent
LigandPNGBDBM22971(2-[(2,6-dichloro-3-methylphenyl)amino]benzoic acid...)
Affinity DataKd:  480nMAssay Description:Binding affinity to TTR (unknown origin) by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed