Compile Data Set for Download or QSAR
Report error Found 8 Enz. Inhib. hit(s) with Target = 'Trifunctional purine biosynthetic protein adenosine-3' and Ligand = 'BDBM22590'
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
Hebei Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22590BDBM22590(5,10-dideazatetrahydrofolic acid | DDF | (2S)-2-[(...)
Affinity DataKi:  6nMAssay Description:Inhibition of GARFTase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
Hebei Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22590BDBM22590(5,10-dideazatetrahydrofolic acid | DDF | (2S)-2-[(...)
Affinity DataIC50: 14nMAssay Description:Inhibition of GARFTase in human KB cells assessed as inhibition of incorporation of [14C]glycine into [14C]formyl GAR after 30 mins in presence of az...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
Hebei Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22590BDBM22590(5,10-dideazatetrahydrofolic acid | DDF | (2S)-2-[(...)
Affinity DataKi:  60nM ΔG°:  -41.4kJ/molepH: 7.5 T: 2°CAssay Description:Assays were initiated by the addition of GAR to the reaction mixture containing GAR Tfase, test compounds, and cofactor. The assay monitors the defor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2008
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
Hebei Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22590BDBM22590(5,10-dideazatetrahydrofolic acid | DDF | (2S)-2-[(...)
Affinity DataKi:  60nM ΔG°:  -41.4kJ/molepH: 7.5 T: 2°CAssay Description:Assays were initiated by the addition of GAR to the reaction mixture containing GAR Tfase, test compounds, and cofactor. The assay monitors the defor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2008
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 22590BDBM22590(5,10-dideazatetrahydrofolic acid | DDF | (2S)-2-[(...)
Affinity DataKi:  60nMAssay Description:Tested in vitro for its inhibition of trifunctional glycinamide ribonucleotide formyltransferase (GARFT) isolated from murine L1210 leukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

LigandChemical structure of BindingDB Monomer ID 22590BDBM22590(5,10-dideazatetrahydrofolic acid | DDF | (2S)-2-[(...)
Affinity DataKi:  120nMAssay Description:Tested for the inhibition of trifunctional Glycinamide ribonucleotide formyltransferase isolated from murine L1210 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
Hebei Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22590BDBM22590(5,10-dideazatetrahydrofolic acid | DDF | (2S)-2-[(...)
Affinity DataKi:  130nMAssay Description:Tested for the inhibition of recombinant human monofunctional Glycinamide ribonucleotide formyltransferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

LigandChemical structure of BindingDB Monomer ID 22590BDBM22590(5,10-dideazatetrahydrofolic acid | DDF | (2S)-2-[(...)
Affinity DataIC50: 780nMAssay Description:Inhibition of mouse recombinant GARFTaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed