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Found 4 Enz. Inhib. hit(s) with Target = 'Tumor necrosis factor' and Ligand = 'BDBM14361'
TargetTumor necrosis factor(Homo sapiens (Human))
Padmashri Vikhe Patil College Of Arts

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  200nMAssay Description:Inhibition of LPS-induced TNF-alpha production in human MNC suspension after 20 hrs by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor(Homo sapiens (Human))
Padmashri Vikhe Patil College Of Arts

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  500nMAssay Description:Inhibition of TNFalpha in LPS-stimulated human mononuclear cell line by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTumor necrosis factor(Homo sapiens (Human))
Padmashri Vikhe Patil College Of Arts

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  500nMAssay Description:Inhibition of LPS-induced TNF-alpha production in human PBMC preincubated for 30 mins followed by LPS addition measured after 5 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor(Homo sapiens (Human))
Padmashri Vikhe Patil College Of Arts

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  1.20E+4nMAssay Description:TNF-alpha production in PBMC by ELISA methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed