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Found 3 Enz. Inhib. hit(s) with Target = 'Tumor necrosis factor' and Ligand = 'BDBM50566087'
TargetTumor necrosis factor(Mus musculus)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50566087(CHEMBL4787790)
Affinity DataIC50:  119nMAssay Description:Inhibition of TNFalpha in mouse L929 cells exposed to compound incubated for 1 hr with mouse TNFalpha by luminescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetTumor necrosis factor(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50566087(CHEMBL4787790)
Affinity DataIC50:  163nMAssay Description:Inhibition of probe-5 binding to human TNFalpha (77 to 233 residues) at 1 nM by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTumor necrosis factor(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50566087(CHEMBL4787790)
Affinity DataKd:  7.30nMAssay Description:Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB