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Found 6 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase BTK' and Ligand = 'BDBM467718'
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM467718((R)-N-(1-Acryloylpyrrolidin-3-yl)-5-(2-methyl-4-(2...)
Affinity DataKi:  29nMAssay Description:Inhibition of full length N-terminal GST-tagged human BTK expressed in Sf21 cells assessed as inhibition constant using NH2-KKKAPFSWYLPEEG as substra...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM467718((R)-N-(1-Acryloylpyrrolidin-3-yl)-5-(2-methyl-4-(2...)
Affinity DataKi:  29nMAssay Description:Covalent inhibition of recombinant human GST-tagged BTK (2 to 659 end residues) expressed in baculovirus expression system assessed as inhibition con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Mus musculus)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM467718((R)-N-(1-Acryloylpyrrolidin-3-yl)-5-(2-methyl-4-(2...)
Affinity DataIC50:  11nMAssay Description:Inhibition of BTK in C57Bl/6 mouse splenocyte assessed as reduction in anti-IgM-induced CD69 expression incubated for 1 hr followed anti-IgM stimulat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM467718((R)-N-(1-Acryloylpyrrolidin-3-yl)-5-(2-methyl-4-(2...)
Affinity DataIC50:  15.8nMAssay Description:TBDMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM467718((R)-N-(1-Acryloylpyrrolidin-3-yl)-5-(2-methyl-4-(2...)
Affinity DataIC50:  84nMAssay Description:Inhibition of BTK in human whole blood assessed as inhibition of IgM-induced B-cell activationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM467718((R)-N-(1-Acryloylpyrrolidin-3-yl)-5-(2-methyl-4-(2...)
Affinity DataIC50:  142nMAssay Description:Inhibition of recombinant human BTK using KVEKIGEGTYGVVYK as substrate incubated for 40 mins in presence of [gamma33P]ATP by scintillation counting m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed