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Found 3 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase ITK/TSK' and Ligand = 'BDBM50022932'
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50022932(CHEMBL3298371)
Affinity DataKi:  0.700nMAssay Description:Inhibition of GST-tagged full length ITK (unknown origin) using BLK peptide as substrate after 35 minsMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50022932(CHEMBL3298371)
Affinity DataIC50:  45nMAssay Description:Inhibition of ITK in TCR stimulated human Jurkat T cells assessed as reduction of PLC-gamma phosphorylation preincubated for 30 mins followed by TCR ...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50022932(CHEMBL3298371)
Affinity DataIC50:  55nMAssay Description:Inhibition of ITK in human Jurkat cells assessed as reduction in PLC-gamma phosphorylation after 30 minsMore data for this Ligand-Target Pair