Found 13 Enz. Inhib. hit(s) with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 4A' and Ligand = 'BDBM14361'
Affinity DataKi: 7.94E+3nM ΔG°: -28.8kJ/molepH: 8.0 T: 2°CAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human PDE4A expressed in Sf9 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 5.90nMAssay Description:Inhibition of phosphodiesterase (PDE) 4AMore data for this Ligand-Target Pair
Affinity DataIC50: 10.7nMAssay Description:Evaluated in vitro for its inhibitory activity on unpurified recombinant Phosphodiesterase type 4A (PDE4A).More data for this Ligand-Target Pair
Affinity DataIC50: 67nMAssay Description:Inhibition of PDE4A (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 162nMAssay Description:Inhibition of human recombinant PDE4AMore data for this Ligand-Target Pair
Affinity DataIC50: 241nMAssay Description:Inhibition of PDE4A4 expressed in yeastMore data for this Ligand-Target Pair
Affinity DataIC50: 386nMAssay Description:Inhibition of full length human PDE4A4 using FAM-3',5'-cAMP as substrate after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 830nMAssay Description:Inhibition of full-length PDE4A4 using cAMP as substrate by two-step radiochemical assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibitory activity against Phosphodiesterase 4A (PDE4A) from human source expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair
Affinity DataIC50: 1.95E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged PDE4A4 (2 to 886 residues) expressed in baculovirus infected Sf9 cells using cAMP as substrate ...More data for this Ligand-Target Pair
Affinity DataEC50: 500nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair