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Found 4 Enz. Inhib. hit(s) with Target = 'eIF-2-alpha kinase GCN2' and Ligand = 'BDBM615005'
TargeteIF-2-alpha kinase GCN2(Homo sapiens (Human))
Ip2Ipo Innovations

US Patent
LigandPNGBDBM615005(US20230271939, Comp Ex 4 | WO2018030466, Example 5)
Affinity DataKi:  0.5nMAssay Description:The inhibitory activity of the Example compounds towards GCN2 enzyme was measured according to the description below, using a LanthaScreen TR-FRET (T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargeteIF-2-alpha kinase GCN2(Homo sapiens (Human))
Ip2Ipo Innovations

US Patent
LigandPNGBDBM615005(US20230271939, Comp Ex 4 | WO2018030466, Example 5)
Affinity DataKi:  1.80nMAssay Description:The inhibitory activity of the Example compounds towards GCN2 enzyme was measured according to the description below, using a LanthaScreen TR-FRET (T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargeteIF-2-alpha kinase GCN2(Homo sapiens (Human))
Ip2Ipo Innovations

US Patent
LigandPNGBDBM615005(US20230271939, Comp Ex 4 | WO2018030466, Example 5)
Affinity DataIC50:  5.80nMAssay Description:The inhibitory activity of the Example compounds towards GCN2 enzyme was measured according to the description below, using a LanthaScreen TR-FRET (T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargeteIF-2-alpha kinase GCN2(Homo sapiens (Human))
Ip2Ipo Innovations

US Patent
LigandPNGBDBM615005(US20230271939, Comp Ex 4 | WO2018030466, Example 5)
Affinity DataIC50:  31nMAssay Description:The inhibitory activity of the Example compounds towards GCN2 enzyme was measured according to the description below, using a LanthaScreen TR-FRET (T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent