Affinity DataKi: 3nM ΔG°: -11.5kcal/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:Binding affinity to human 11beta-HSD1 by SPA assayMore data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:Binding affinity to human 11beta-HSD1 by SPA assayMore data for this Ligand-Target Pair
Affinity DataKi: 6nMAssay Description:Binding affinity to human 11beta-HSD1 by SPA assayMore data for this Ligand-Target Pair
Affinity DataKi: 6nMAssay Description:Binding affinity to human 11beta-HSD1 by SPA assayMore data for this Ligand-Target Pair
Affinity DataKi: 7nMAssay Description:Binding affinity to human 11beta-HSD1 by SPA assayMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Binding affinity to human 11beta-HSD1 by SPA assayMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Binding affinity to human 11beta-HSD1 by SPA assayMore data for this Ligand-Target Pair
Affinity DataKi: 12nM ΔG°: -10.7kcal/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
Affinity DataKi: 13nM ΔG°: -10.6kcal/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
Affinity DataKi: 13nM ΔG°: -10.6kcal/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:Binding affinity to human 11beta-HSD1 by SPA assayMore data for this Ligand-Target Pair
Affinity DataKi: 14nM ΔG°: -10.6kcal/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Binding affinity to human 11beta-HSD1 by SPA assayMore data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Binding affinity to human 11beta-HSD1 by SPA assayMore data for this Ligand-Target Pair
Affinity DataKi: 18nMAssay Description:Binding affinity to human 11beta-HSD1 by SPA assayMore data for this Ligand-Target Pair
Affinity DataKi: 19nMAssay Description:Binding affinity to human 11beta-HSD1 by SPA assayMore data for this Ligand-Target Pair
Affinity DataKi: 20nMAssay Description:Binding affinity to human 11beta-HSD1 by SPA assayMore data for this Ligand-Target Pair
Affinity DataKi: 20nM ΔG°: -10.4kcal/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
Affinity DataKi: 22nMAssay Description:Binding affinity to human 11beta-HSD1 by SPA assayMore data for this Ligand-Target Pair
Affinity DataKi: 24nM ΔG°: -10.3kcal/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
Affinity DataKi: 24nM ΔG°: -10.3kcal/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
Affinity DataKi: 25nMAssay Description:Binding affinity to human 11beta-HSD1 by SPA assayMore data for this Ligand-Target Pair
Affinity DataKi: 25nM ΔG°: -10.3kcal/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
Affinity DataKi: 26nM ΔG°: -10.2kcal/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
Affinity DataKi: 28nM ΔG°: -10.2kcal/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
Affinity DataKi: 28nM ΔG°: -10.2kcal/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
Affinity DataKi: 32nM ΔG°: -10.1kcal/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
Affinity DataKi: 34nM ΔG°: -10.1kcal/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
Affinity DataKi: 38nM ΔG°: -10.0kcal/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
Affinity DataKi: 39nMAssay Description:Binding affinity to human 11beta-HSD1 by SPA assayMore data for this Ligand-Target Pair
Affinity DataKi: 43nMAssay Description:Binding affinity to human 11beta-HSD1 by SPA assayMore data for this Ligand-Target Pair
Affinity DataKi: 46nMAssay Description:Binding affinity to human 11beta-HSD1 by SPA assayMore data for this Ligand-Target Pair
Affinity DataKi: 47nM ΔG°: -9.89kcal/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
Affinity DataKi: 55nM ΔG°: -9.80kcal/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
Affinity DataKi: 58nM ΔG°: -9.77kcal/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
Affinity DataKi: 64nM ΔG°: -9.71kcal/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
Affinity DataKi: 73nM ΔG°: -9.63kcal/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
Affinity DataKi: 77nMAssay Description:Binding affinity to human 11beta-HSD1 by SPA assayMore data for this Ligand-Target Pair
Affinity DataKi: 82nM ΔG°: -9.56kcal/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
Affinity DataKi: 100nMAssay Description:Inhibition of human 11betaHSD1 by SPAMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Biovitrum
Curated by ChEMBL
Biovitrum
Curated by ChEMBL
Affinity DataKi: 100nMAssay Description:Ligand binding affinity was determined by displacement of a tritiated tracer by the unlabeled compound to a GST-PPAR fusion protein for Peroxisome pr...More data for this Ligand-Target Pair
Affinity DataKi: 110nMAssay Description:Inhibition of human 11betaHSD1 by SPAMore data for this Ligand-Target Pair
Affinity DataKi: 120nM ΔG°: -9.34kcal/molepH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant enzymes, incubating with test compound and [3H]cortisone/NADPH. After incubation, the amount ...More data for this Ligand-Target Pair
Affinity DataKi: 126nM ΔG°: -9.31kcal/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
Affinity DataKi: 140nMAssay Description:Inhibition of human 11betaHSD1 by SPAMore data for this Ligand-Target Pair
Affinity DataKi: 149nM ΔG°: -9.21kcal/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Biovitrum
Curated by ChEMBL
Biovitrum
Curated by ChEMBL
Affinity DataKi: 160nMAssay Description:Ligand binding affinity was determined by displacement of a tritiated tracer by the unlabeled compound to a GST-PPAR fusion protein for Peroxisome pr...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Biovitrum
Curated by ChEMBL
Biovitrum
Curated by ChEMBL
Affinity DataKi: 170nMAssay Description:Ligand binding affinity was determined by displacement of a tritiated tracer by the unlabeled compound to a GST-PPAR fusion protein for Peroxisome pr...More data for this Ligand-Target Pair
Affinity DataKi: 170nMAssay Description:Inhibition of human 11betaHSD1 by SPAMore data for this Ligand-Target Pair