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TargetMitogen-activated protein kinase 14(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14831(diaryl urea compound 2 | 3-(3-tert-butyl-1-methyl-...)
Affinity DataKd:  1.16E+3nMpH: 7.0 T: 2°CAssay Description:The exchange curve assays were run as two half-reactions using an SLM Aminco Bowman Series 2 model SQ-340 fluorescence detector. In the first half re...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14832(4-[6-(4-fluorophenyl)-2H,3H-imidazo[2,1-b][1,3]thi...)
Affinity DataKd:  180nMpH: 7.0 T: 2°CAssay Description:The exchange curve assays were run as two half-reactions using an SLM Aminco Bowman Series 2 model SQ-340 fluorescence detector. In the first half re...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataKd:  0.100nMpH: 7.0 T: 2°CAssay Description:The exchange curve assays were run as two half-reactions using an SLM Aminco Bowman Series 2 model SQ-340 fluorescence detector. In the first half re...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM13336(4-{4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]...)
Affinity DataKd:  20nMpH: 7.0 T: 2°CAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14834(3-[3-(1-hydroxy-2-methylpropan-2-yl)-1-(4-methylph...)
Affinity DataKd:  56nMpH: 7.0 T: 2°CAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
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PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14842(1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}-3-...)
Affinity DataKd:  2.40E+3nMpH: 7.0 T: 2°CAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14838(CHEMBL105248 | BIRB-796 Analog 32 | 1-(5-iso-Propy...)
Affinity DataKd:  3.40nMpH: 7.0 T: 2°CAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14839(BIRB-796 Analog 33 | 3-(3-tert-butyl-1-phenyl-1H-p...)
Affinity DataKd:  0.230nMpH: 7.0 T: 2°CAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14843(3-[3-(1-methylcyclohexyl)-1-phenyl-1H-pyrazol-5-yl...)
Affinity DataKd:  1.90nMpH: 7.0 T: 2°CAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataKd:  0.0460nMpH: 7.0 T: 2°CAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14844(3-[3-tert-butyl-1-(6-methylpyridin-3-yl)-1H-pyrazo...)
Affinity DataKd:  0.180nMpH: 7.0 T: 2°CAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14845(3-(1-benzyl-3-tert-butyl-1H-pyrazol-5-yl)-1-{4-[2-...)
Affinity DataKd:  64nMpH: 7.0 T: 2°CAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14835(3-(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)-1-{4-[2-...)
Affinity DataKd:  26nMpH: 7.0 T: 2°CAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14846(3-(3-tert-butyl-1-cyclohexyl-1H-pyrazol-5-yl)-1-{4...)
Affinity DataKd:  23nMpH: 7.0 T: 2°CAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14847(3-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]...)
Affinity DataKd:  0.230nMpH: 7.0 T: 2°CAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14848(N-(3-{3-tert-butyl-5-[({4-[2-(morpholin-4-yl)ethox...)
Affinity DataKd:  9.90nMpH: 7.0 T: 2°CAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14849(3-[1-(4-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]...)
Affinity DataKd:  0.160nMpH: 7.0 T: 2°CAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14850(N-(4-{3-tert-butyl-5-[({4-[2-(morpholin-4-yl)ethox...)
Affinity DataKd:  64nMAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14851(3-[3-tert-butyl-1-(6-methoxypyridin-3-yl)-1H-pyraz...)
Affinity DataKd:  0.870nMAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14837(BIRB-796 Analog 4 | 3-[3-tert-butyl-1-(4-methylphe...)
Affinity DataKd:  11nMAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14853(3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl...)
Affinity DataKd:  0.400nMAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14840(BIRB-796 Analog 30 | 3-[3-tert-butyl-1-(4-methylph...)
Affinity DataKd:  0.100nMAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14855(3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl...)
Affinity DataKd:  14nMAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14856(3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl...)
Affinity DataKd:  12nMAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14857(1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-{4-[2...)
Affinity DataKd:  1.5nMAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14858(3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl...)
Affinity DataKd:  0.0960nMAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14859(3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl...)
Affinity DataKd:  5.90nMAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14860(1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2...)
Affinity DataKd:  0.520nMAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14861(3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl...)
Affinity DataKd:  3.5nMAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14862(1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2...)
Affinity DataKd:  0.0740nMAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMacrophage migration inhibitory factor(Human)
L2 Diagnostics

Curated by ChEMBL
LigandPNGBDBM50458539(CHICAGO SKY BLUE SODIUM | Chicago Sky Blue | Chica...)
Affinity DataKd:  9.04E+3nMAssay Description:Binding affinity to recombinant biotinylated human MIF expressed in Escherichia coli BL21 DE3 by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMacrophage migration inhibitory factor(Human)
L2 Diagnostics

Curated by ChEMBL
LigandPNGBDBM50547499(CHEMBL4785454)
Affinity DataKd:  6.86E+3nMAssay Description:Binding affinity to recombinant biotinylated human MIF expressed in Escherichia coli BL21 DE3 by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMacrophage migration inhibitory factor(Human)
L2 Diagnostics

Curated by ChEMBL
LigandPNGBDBM50240404(CHEMBL19449 | (Ibudilast)1-(2-Isopropyl-pyrazolo[1...)
Affinity DataKd:  1.40E+3nMAssay Description:Binding affinity to recombinant biotinylated human MIF expressed in Escherichia coli BL21 DE3 by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM50132411(5-(3-tert-Butyl-5-{3-[4-(2-morpholin-4-yl-ethoxy)-...)
Affinity DataKon:  0.0000620M-1s-1 Koff:  2.52E+4s-1Assay Description:Rate of dissociation from Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14831(diaryl urea compound 2 | 3-(3-tert-butyl-1-methyl-...)
Affinity DataKoff:  1.18E+5s-1Assay Description:Rate of association to Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM50132413(1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[3-me...)
Affinity DataKon:  0.000150M-1s-1 Koff:  1.07E+4s-1Assay Description:Rate of dissociation from Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM50132415(1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(3...)
Affinity DataKon:  0.0000230M-1s-1 Koff:  1.87E+4s-1Assay Description:Rate of dissociation from Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14831(diaryl urea compound 2 | 3-(3-tert-butyl-1-methyl-...)
Affinity DataKon:  0.140M-1s-1 Koff:  1.18E+5s-1Assay Description:Rate of dissociation from Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14837(BIRB-796 Analog 4 | 3-[3-tert-butyl-1-(4-methylphe...)
Affinity DataKon:  0.000120M-1s-1 Koff:  1.13E+5s-1Assay Description:Rate of dissociation from Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14839(BIRB-796 Analog 33 | 3-(3-tert-butyl-1-phenyl-1H-p...)
Affinity DataKon:  0.0000150M-1s-1 Koff:  1.54E+5s-1Assay Description:Rate of dissociation from Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14835(3-(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)-1-{4-[2-...)
Affinity DataKon:  0.00330M-1s-1 Koff:  1.45E+5s-1Assay Description:Rate of dissociation from Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14837(BIRB-796 Analog 4 | 3-[3-tert-butyl-1-(4-methylphe...)
Affinity DataKon:  0.000120M-1s-1Assay Description:Rate of dissociation from Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14836(3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl...)
Affinity DataKon:  0.00160M-1s-1 Koff:  7.33E+4s-1Assay Description:Rate of dissociation from Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14838(CHEMBL105248 | BIRB-796 Analog 32 | 1-(5-iso-Propy...)
Affinity DataKon:  0.000380M-1s-1 Koff:  6.48E+4s-1Assay Description:Rate of dissociation from Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM50132414(1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-(3-me...)
Affinity DataKon:  0.000340M-1s-1 Koff:  3.61E+4s-1Assay Description:Rate of dissociation from Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14837(BIRB-796 Analog 4 | 3-[3-tert-butyl-1-(4-methylphe...)
Affinity DataKd:  1.10nMAssay Description:Binding affinity for Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14834(3-[3-(1-hydroxy-2-methylpropan-2-yl)-1-(4-methylph...)
Affinity DataKon:  0.000400M-1s-1 Koff:  2.54E+4s-1Assay Description:Rate of dissociation from Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM50115209(CHEMBL101035 | 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazo...)
Affinity DataKon:  0.00390M-1s-1Assay Description:Rate of dissociation from Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14844(3-[3-tert-butyl-1-(6-methylpyridin-3-yl)-1H-pyrazo...)
Affinity DataKon:  0.0000230M-1s-1 Koff:  2.15E+4s-1Assay Description:Rate of dissociation from Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM50132413(1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[3-me...)
Affinity DataKoff:  1.07E+4s-1Assay Description:Rate of association to Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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