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Found 652 with Last Name = 'dowling' and Initial = 'je'
TargetAdenosine receptor A2a(Homo sapiens (Human))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM21190(4-(2-{[5-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity towards adenosine A2A receptorMore data for this Ligand-Target Pair
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50199270(1,3-dipropyl-8-[2-(5,6-exo-epoxy-(1S,2S)-norborn-2...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]CPX from rat brain cortex adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50173186(8-Amino-2-furan-2-yl-[1,2,4]triazolo[1,5-a]pyrazin...)
Affinity DataKi:  1nMAssay Description:Binding affinity towards adenosine A2a receptor of rat brain homogenates using [3H]-ZM-241,385 compared to SCH-58261 (Ki=37 nM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50173189(3-(8-Amino-2-furan-2-yl-[1,2,4]triazolo[1,5-a]pyra...)
Affinity DataKi:  1nMAssay Description:Binding affinity towards adenosine A2a receptor of rat brain homogenates using [3H]-ZM-241,385 compared to SCH-58261 (Ki=37 nM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50173176(8-Amino-2-furan-2-yl-[1,2,4]triazolo[1,5-a]pyrazin...)
Affinity DataKi:  1nMAssay Description:Binding affinity towards adenosine A2a receptor of rat brain homogenates using [3H]-ZM-241,385 compared to SCH-58261 (Ki=37 nM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50199269(3-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]CPX from rat brain cortex adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50173201(8-Amino-2-furan-2-yl-[1,2,4]triazolo[1,5-a]pyrazin...)
Affinity DataKi:  2nMAssay Description:Binding affinity towards adenosine A2a receptor of rat brain homogenates using [3H]-ZM-241,385 compared to SCH-58261 (Ki=37 nM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50048466(2-(furan-2-yl)-7-phenethyl-7H-pyrazolo[4,3-e][1,2,...)
Affinity DataKi:  2.30nMAssay Description:Binding affinity towards adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50173179(CHEMBL196104 | [3-(8-Amino-2-furan-2-yl-[1,2,4]tri...)
Affinity DataKi:  3nMAssay Description:Binding affinity towards adenosine A1 receptor of rat cerebral cortex using [3H]-DPCPX compared to SCH-58261 (Ki=390 nM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50199276(4-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]CPX from rat brain cortex adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50199272(4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-pu...)
Affinity DataKi:  6nMAssay Description:Displacement of [125I]ABA from human adenosine A1 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50199269(3-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H...)
Affinity DataKi:  7.40nMAssay Description:Displacement of [125I]ABA from human adenosine A1 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50199284(4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-pu...)
Affinity DataKi:  7.80nMAssay Description:Displacement of [3H]CPX from rat brain cortex adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50199280(CHEMBL424908 | {[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7...)
Affinity DataKi:  8nMAssay Description:Displacement of [125I]ABA from human adenosine A1 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50199274(3-noradamantyl-1,3-dipropylxanthine | CHEMBL385372)
Affinity DataKi:  8nMAssay Description:Displacement of [125I]ABA from human adenosine A1 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50199285(4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-pu...)
Affinity DataKi:  9nMAssay Description:Displacement of [125I]ABA from human adenosine A1 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50199268((E)-3-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydr...)
Affinity DataKi:  9.60nMAssay Description:Displacement of [125I]ABA from human adenosine A1 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50199270(1,3-dipropyl-8-[2-(5,6-exo-epoxy-(1S,2S)-norborn-2...)
Affinity DataKi:  12nMAssay Description:Displacement of [125I]ABA from human adenosine A1 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50199283(4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-pu...)
Affinity DataKi:  12nMAssay Description:Displacement of [125I]ABA from human adenosine A1 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50173201(8-Amino-2-furan-2-yl-[1,2,4]triazolo[1,5-a]pyrazin...)
Affinity DataKi:  14nMAssay Description:Binding affinity towards adenosine A1 receptor of rat cerebral cortex using [3H]-DPCPX compared to SCH-58261 (Ki=390 nM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50199286(4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-pu...)
Affinity DataKi:  15nMAssay Description:Displacement of [125I]ABA from human adenosine A1 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50199281(8-(4-hydroxymethyl-bicyclo[2.2.2]oct-1-yl)-1,3-dip...)
Affinity DataKi:  16nMAssay Description:Displacement of [125I]ABA from human adenosine A1 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50173188(CHEMBL383568 | [4-(8-Amino-2-furan-2-yl-[1,2,4]tri...)
Affinity DataKi:  19nMAssay Description:Binding affinity towards adenosine A2a receptor of rat brain homogenates using [3H]-ZM-241,385 compared to SCH-58261 (Ki=37 nM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50199282(3-{[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1...)
Affinity DataKi:  22nMAssay Description:Displacement of [125I]ABA from human adenosine A1 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50199288(CHEMBL425457 | [4-(2,6-dioxo-1,3-dipropyl-2,3,6,9-...)
Affinity DataKi:  23nMAssay Description:Displacement of [3H]CPX from rat brain cortex adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50173200(8-Amino-2-furan-2-yl-[1,2,4]triazolo[1,5-a]pyrazin...)
Affinity DataKi:  27nMAssay Description:Binding affinity towards adenosine A2a receptor of rat brain homogenates using [3H]-ZM-241,385 compared to SCH-58261 (Ki=37 nM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50173182(8-Amino-2-furan-2-yl-[1,2,4]triazolo[1,5-a]pyrazin...)
Affinity DataKi:  28nMAssay Description:Binding affinity towards adenosine A2a receptor of rat brain homogenates using [3H]-ZM-241,385 compared to SCH-58261 (Ki=37 nM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50199276(4-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H...)
Affinity DataKi:  29nMAssay Description:Displacement of [125I]ABA from human adenosine A1 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50199284(4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-pu...)
Affinity DataKi:  33nMAssay Description:Displacement of [125I]ABA from human adenosine A1 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50173192(4-(8-Amino-2-furan-2-yl-[1,2,4]triazolo[1,5-a]pyra...)
Affinity DataKi:  36nMAssay Description:Binding affinity towards adenosine A1 receptor of rat cerebral cortex using [3H]-DPCPX compared to SCH-58261 (Ki=390 nM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50173189(3-(8-Amino-2-furan-2-yl-[1,2,4]triazolo[1,5-a]pyra...)
Affinity DataKi:  41nMAssay Description:Binding affinity towards adenosine A1 receptor of rat cerebral cortex using [3H]-DPCPX compared to SCH-58261 (Ki=390 nM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50199278(8-(4-hydroxymethyl-cyclohexyl)-1,3-dipropyl-3,7-di...)
Affinity DataKi:  41nMAssay Description:Displacement of [125I]ABA from human adenosine A1 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50199271(4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-pu...)
Affinity DataKi:  46nMAssay Description:Displacement of [125I]ABA from human adenosine A1 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50199273(CHEMBL386777 | {[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7...)
Affinity DataKi:  49nMAssay Description:Displacement of [125I]ABA from human adenosine A1 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM22590((2S)-2-[(4-{2-[(6R)-2-amino-4-oxo-1H,4H,5H,6H,7H,8...)
Affinity DataKi:  60nMAssay Description:Tested in vitro for its inhibition of trifunctional glycinamide ribonucleotide formyltransferase (GARFT) isolated from murine L1210 leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50173177(3-(8-Amino-2-furan-2-yl-[1,2,4]triazolo[1,5-a]pyra...)
Affinity DataKi:  70nMAssay Description:Binding affinity towards adenosine A2a receptor of rat brain homogenates using [3H]-ZM-241,385 compared to SCH-58261 (Ki=37 nM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50173202(1-[3-(8-Amino-2-furan-2-yl-[1,2,4]triazolo[1,5-a]p...)
Affinity DataKi:  75nMAssay Description:Binding affinity towards adenosine A2a receptor of rat brain homogenates using [3H]-ZM-241,385 compared to SCH-58261 (Ki=37 nM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50199269(3-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H...)
Affinity DataKi:  90nMAssay Description:Displacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50199275(1-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H...)
Affinity DataKi:  96nMAssay Description:Displacement of [125I]ABA from human adenosine A1 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50199268((E)-3-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydr...)
Affinity DataKi:  100nMAssay Description:Displacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50199279(CHEMBL274199 | trans-[4-(2,6-dioxo-1,3-dipropyl-2,...)
Affinity DataKi:  109nMAssay Description:Displacement of [125I]ABA from human adenosine A1 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50173210(2-Furan-2-yl-6-(3-methanesulfonyl-phenyl)-[1,2,4]t...)
Affinity DataKi:  110nMAssay Description:Binding affinity towards adenosine A2a receptor of rat brain homogenates using [3H]-ZM-241,385 compared to SCH-58261 (Ki=37 nM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50173180(3-(8-Amino-2-furan-2-yl-[1,2,4]triazolo[1,5-a]pyra...)
Affinity DataKi:  110nMAssay Description:Binding affinity towards adenosine A2a receptor of rat brain homogenates using [3H]-ZM-241,385 compared to SCH-58261 (Ki=37 nM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50199287(2-((4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1...)
Affinity DataKi:  112nMAssay Description:Displacement of [125I]ABA from human adenosine A1 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50173177(3-(8-Amino-2-furan-2-yl-[1,2,4]triazolo[1,5-a]pyra...)
Affinity DataKi:  120nMAssay Description:Binding affinity towards adenosine A1 receptor of rat cerebral cortex using [3H]-DPCPX compared to SCH-58261 (Ki=390 nM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50173186(8-Amino-2-furan-2-yl-[1,2,4]triazolo[1,5-a]pyrazin...)
Affinity DataKi:  120nMAssay Description:Binding affinity towards adenosine A1 receptor of rat cerebral cortex using [3H]-DPCPX compared to SCH-58261 (Ki=390 nM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50003896((DDATHF) 5,10-Dideazatetrahydrofolic acid2-{4-[2-(...)
Affinity DataKi:  120nMAssay Description:Tested in vitro for its inhibition of trifunctional glycinamide ribonucleotide formyltransferase (GARFT) isolated from murine L1210 leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAdenosine receptor A2b(Homo sapiens (Human))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50199276(4-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H...)
Affinity DataKi:  127nMAssay Description:Displacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50199272(4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-pu...)
Affinity DataKi:  132nMAssay Description:Displacement of [125I]ZM241385 from human adenosine A2A receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Biogen Idec Inc

Curated by ChEMBL
LigandPNGBDBM50173212(6-(3-Dimethylamino-phenyl)-2-furan-2-yl-[1,2,4]tri...)
Affinity DataKi:  140nMAssay Description:Binding affinity towards adenosine A2a receptor of rat brain homogenates using [3H]-ZM-241,385 compared to SCH-58261 (Ki=37 nM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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