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Found 47 with Last Name = 'foster' and Initial = 'm'
TargetGlucocorticoid receptor(Homo sapiens (Human))
Imperial College

Curated by PDSP Ki Database
LigandPNGBDBM50354849(CCI-18781 | Cutivate | FLUTICASONE PROPIONATE | Fl...)
Affinity DataKi:  0.238nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetGlucocorticoid receptor(Homo sapiens (Human))
Imperial College

Curated by PDSP Ki Database
LigandPNGBDBM86696(des-CIC | desisobutyryl-ciclesonide)
Affinity DataKi:  0.310nMMore data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
Imperial College

Curated by PDSP Ki Database
LigandPNGBDBM18207((1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dih...)
Affinity DataKi:  6.70nMMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 13(Mus musculus)
Aventis Pharma

Curated by ChEMBL
LigandPNGBDBM50219254(CHEMBL347592)
Affinity DataIC50:  5nMAssay Description:Inhibition of murine Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 13(Mus musculus)
Aventis Pharma

Curated by ChEMBL
LigandPNGBDBM50219252(CHEMBL159932)
Affinity DataIC50:  7nMAssay Description:Inhibition of murine Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 13(Mus musculus)
Aventis Pharma

Curated by ChEMBL
LigandPNGBDBM50219253(CHEMBL161197)
Affinity DataIC50:  9nMAssay Description:Inhibition of murine Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Mus musculus)
Aventis Pharma

Curated by ChEMBL
LigandPNGBDBM50219251(CHEMBL423071)
Affinity DataIC50:  16nMAssay Description:Inhibitory activity against p38 kinase (40 ng/well) was determined in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132421(3-[1-(1H-Pyrrol-2-yl)-meth-(Z)-ylidene]-5-(thiophe...)
Affinity DataIC50:  26nMAssay Description:Inhibitory activity against Janus Kinase 3 protein tyrosine kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132420(3-((1H-pyrrol-2-yl)methylene)-5-(pyridin-3-yl)indo...)
Affinity DataIC50:  27nMAssay Description:Inhibitory activity against Janus Kinase 3 protein tyrosine kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132427(5-Pyridin-3-yl-3-[1-(1H-pyrrol-2-yl)-meth-(Z)-ylid...)
Affinity DataIC50:  30nMAssay Description:Inhibitory activity against Janus Kinase 3 protein tyrosine kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Santhera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50174302(CHEMBL200283 | N-((S)-1-((S)-1-(4-bromophenyl)-4-(...)
Affinity DataIC50:  40nMAssay Description:Inhibitory activity against cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth factor receptor-bound protein 2(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50547626(CHEMBL4760821)
Affinity DataIC50:  100nMAssay Description:Binding affinity to Grb2-SH2 domain (unknown origin) expressed in Escherichia coli BL21 (DE23) after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Santhera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50174304(CHEMBL198962 | N-((S)-1-((S)-1-(4-chlorophenyl)-4-...)
Affinity DataIC50:  100nMAssay Description:Inhibitory activity against cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Santhera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073850((S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyr...)
Affinity DataIC50:  100nMAssay Description:Inhibitory activity against cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Santhera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50174313((S)-2-(5-[1,2]dithiolan-3-yl-pentanoylamino)-4-met...)
Affinity DataIC50:  120nMAssay Description:Inhibitory activity against cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132422(5-(Pyridine-3-carbonyl)-3-[1-(1H-pyrrol-2-yl)-meth...)
Affinity DataIC50:  168nMAssay Description:Inhibitory activity against Janus Kinase 3 protein tyrosine kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132428(5-(Hydroxy-thiophen-2-yl-methyl)-3-[1-(1H-pyrrol-2...)
Affinity DataIC50:  190nMAssay Description:Inhibitory activity against Janus Kinase 3 protein tyrosine kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132417(3-[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-5-...)
Affinity DataIC50:  200nMAssay Description:Inhibitory activity against Janus Kinase 3 protein tyrosine kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132423(2-Oxo-3-[1-(1H-pyrrol-2-yl)-meth-(Z)-ylidene]-2,3-...)
Affinity DataIC50:  210nMAssay Description:Inhibitory activity against Janus Kinase 3 protein tyrosine kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM17032((3Z)-2-oxo-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihyd...)
Affinity DataIC50:  213nMAssay Description:Inhibitory activity against Janus Kinase 3 protein tyrosine kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132419(5-Pyridin-3-yl-3-[1-(1H-pyrrol-2-yl)-meth-(Z)-ylid...)
Affinity DataIC50:  235nMAssay Description:Inhibitory activity against Janus Kinase 3 protein tyrosine kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132424(3-[2-Oxo-2-(1H-pyrrol-2-yl)-eth-(Z)-ylidene]-5-(th...)
Affinity DataIC50:  260nMAssay Description:Inhibitory activity against Janus Kinase 3 protein tyrosine kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132418(5-Pyridin-3-yl-3-[1-(1H-pyrrol-2-yl)-meth-(Z)-ylid...)
Affinity DataIC50:  350nMAssay Description:Inhibitory activity against Janus Kinase 3 protein tyrosine kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth factor receptor-bound protein 2(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50547624(CHEMBL4761634)
Affinity DataIC50:  400nMAssay Description:Binding affinity to Grb2-SH2 domain (unknown origin) expressed in Escherichia coli BL21 (DE23) after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Santhera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50174317((S)-2-(5-[1,2]dithiolan-3-yl-pentanoylamino)-4-met...)
Affinity DataIC50:  650nMAssay Description:Inhibitory activity against cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132426(CHEMBL104062 | N-{4-[2-Oxo-5-(thiophene-2-carbonyl...)
Affinity DataIC50:  700nMAssay Description:Inhibitory activity against Janus Kinase 3 protein tyrosine kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50065287(5-Nitro-3-(1H-pyrrol-2-ylmethylene)-1,3-dihydro-in...)
Affinity DataIC50:  710nMAssay Description:Inhibitory activity against Janus Kinase 3 protein tyrosine kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132429(CHEMBL104409 | N-{2-Oxo-3-[1-(1H-pyrrol-2-yl)-meth...)
Affinity DataIC50:  870nMAssay Description:Inhibitory activity against Janus Kinase 3 protein tyrosine kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM17015((3Z)-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-...)
Affinity DataIC50:  900nMAssay Description:Inhibitory activity against Janus Kinase 3 protein tyrosine kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Massachusetts Boston

Curated by ChEMBL
LigandPNGBDBM50491257(CHEMBL2381384)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of amyloid beta ((1 to 42) (unknown origin) oligomer assembly after 30 mins by biotinyl-streptavidin assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
University Of Massachusetts Boston

Curated by ChEMBL
LigandPNGBDBM50491252(CHEMBL2381401)
Affinity DataIC50:  1.76E+3nMAssay Description:Inhibition of AChE (unknown origin) by Ellman methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
University Of Massachusetts Boston

Curated by ChEMBL
LigandPNGBDBM10404((1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetrac...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of AChE (unknown origin) by Ellman methodMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132431(3-[1-Phenyl-meth-(Z)-ylidene]-5-(thiophene-2-carbo...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibitory activity against Janus Kinase 3 protein tyrosine kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Massachusetts Boston

Curated by ChEMBL
LigandPNGBDBM50491257(CHEMBL2381384)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of amyloid beta (1 to 42) (unknown origin) oligomer dissociation after 16 to 18 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132425(3-[1-(4-Fluoro-phenyl)-meth-(Z)-ylidene]-5-(thioph...)
Affinity DataIC50:  4.90E+3nMAssay Description:Inhibitory activity against Janus Kinase 3 protein tyrosine kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Massachusetts Boston

Curated by ChEMBL
LigandPNGBDBM50491254(CHEMBL2381385)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of amyloid beta (1 to 42) (unknown origin) oligomer dissociation after 16 to 18 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Massachusetts Boston

Curated by ChEMBL
LigandPNGBDBM50491253(CHEMBL2381403)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibition of amyloid beta (1 to 42) (unknown origin) oligomer dissociation after 16 to 18 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132430(3-[1-(4-Methanesulfonyl-phenyl)-meth-(Z)-ylidene]-...)
Affinity DataIC50:  7.10E+3nMAssay Description:Inhibitory activity against Janus Kinase 3 protein tyrosine kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
University Of Massachusetts Boston

Curated by ChEMBL
LigandPNGBDBM50491256(CHEMBL2381400)
Affinity DataIC50:  8.27E+3nMAssay Description:Inhibition of BuChE (unknown origin) by Ellman methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
University Of Massachusetts Boston

Curated by ChEMBL
LigandPNGBDBM10404((1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetrac...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of BuChE (unknown origin) by Ellman methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetGrowth factor receptor-bound protein 2(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50547625(CHEMBL4751079)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity to Grb2-SH2 domain (unknown origin) expressed in Escherichia coli BL21 (DE23) after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Massachusetts Boston

Curated by ChEMBL
LigandPNGBDBM50491258(CHEMBL2381402)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of amyloid beta ((1 to 42) (unknown origin) oligomer assembly after 30 mins by biotinyl-streptavidin assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Massachusetts Boston

Curated by ChEMBL
LigandPNGBDBM50491253(CHEMBL2381403)
Affinity DataIC50:  2.10E+4nMAssay Description:Inhibition of amyloid beta ((1 to 42) (unknown origin) oligomer assembly after 30 mins by biotinyl-streptavidin assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Massachusetts Boston

Curated by ChEMBL
LigandPNGBDBM50491258(CHEMBL2381402)
Affinity DataIC50:  2.90E+4nMAssay Description:Inhibition of amyloid beta (1 to 42) (unknown origin) oligomer dissociation after 16 to 18 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Massachusetts Boston

Curated by ChEMBL
LigandPNGBDBM50491254(CHEMBL2381385)
Affinity DataIC50:  2.90E+4nMAssay Description:Inhibition of amyloid beta ((1 to 42) (unknown origin) oligomer assembly after 30 mins by biotinyl-streptavidin assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Massachusetts Boston

Curated by ChEMBL
LigandPNGBDBM50491255(CHEMBL2381386)
Affinity DataIC50:  3.60E+4nMAssay Description:Inhibition of amyloid beta ((1 to 42) (unknown origin) oligomer assembly after 30 mins by biotinyl-streptavidin assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Massachusetts Boston

Curated by ChEMBL
LigandPNGBDBM50491252(CHEMBL2381401)
Affinity DataIC50:  3.60E+4nMAssay Description:Inhibition of amyloid beta ((1 to 42) (unknown origin) oligomer assembly after 30 mins by biotinyl-streptavidin assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed