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TargetSubstance-P receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50001450(Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met NH2 | ...)
Affinity DataIC50: 0.0700nMAssay Description:Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

TargetSubstance-P receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50001450(Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met NH2 | ...)
Affinity DataIC50: 0.120nMAssay Description:Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

TargetSubstance-P receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50101416([2-(1H-Indol-3-yl)-1-methyl-1-(1-phenyl-ethylcarba...)
Affinity DataIC50: 0.550nMAssay Description:Binding affinity towards tachykinin receptor 1 in human IM9 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
LigandPNGBDBM24185(CGP35024 | 3-Apmpa | CHEMBL112710 | (3-aminopropyl...)
Affinity DataIC50: 1nMAssay Description:In vitro displacement of [3H]GABA from Gamma-aminobutyric acid type B receptor sites in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article
PDB3D3D Structure (crystal)
TargetHistamine H3 receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50071491(4-(1H-Imidazol-4-yl)-butyramidine | SK-91606 | SK&...)
Affinity DataIC50: 1.10nMAssay Description:Histamine H3 receptor agonist activity was assessed by the inhibition of the electrically evoked twitch response of the guinea-pig ileum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetSubstance-P receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50280461(((2R,3R)-2-Benzhydryl-1-aza-bicyclo[2.2.2]oct-3-yl...)
Affinity DataIC50: 1.20nMAssay Description:Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

TargetSubstance-P receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50422068(CHEMBL336439)
Affinity DataIC50: 1.90nMAssay Description:Binding affinity towards tachykinin receptor 1 in human IM9 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50422082(CHEMBL138620)
Affinity DataIC50: 2nMAssay Description:Binding affinity towards tachykinin receptor 1 in human IM9 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50422076(CHEMBL424480)
Affinity DataIC50: 2.10nMAssay Description:Binding affinity towards tachykinin receptor 1 in human IM9 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50422069(CHEMBL142121)
Affinity DataIC50: 2.40nMAssay Description:Binding affinity towards tachykinin receptor 1 in human IM9 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
LigandPNGBDBM24184((3-aminopropyl)phosphinic acid | CHEMBL112203 | CG...)
Affinity DataIC50: 3nMAssay Description:In vitro displacement of [3H]GABA from Gamma-aminobutyric acid type B receptor sites in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetSubstance-P receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50422058(CHEMBL138390)
Affinity DataIC50: 3.20nMAssay Description:Binding affinity towards tachykinin receptor 1 in human IM9 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetSubstance-P receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50001447(His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2(Neurok...)
Affinity DataIC50: 3.5nMAssay Description:Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

TargetHistamine H3 receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM22911(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
Affinity DataIC50: 4.60nMAssay Description:Histamine H3 receptor agonist activity was assessed by the inhibition of the electrically evoked twitch response of the guinea-pig ileum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article
PDB3D3D Structure (crystal)
TargetSubstance-P receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50280458((2-Chloro-benzyl)-[(2R,3R)-2-(2,2-diphenyl-ethyl)-...)
Affinity DataIC50: 8.5nMAssay Description:Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

TargetNeuromedin-K receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50050649({(S)-1-[(R)-1-Methyl-2-phenyl-1-(7-ureido-heptylca...)
Affinity DataIC50: 9nMAssay Description:Binding affinity for NK3 receptor binding sites in guinea pig cortical membranes by using [125I][MePhe7]-NKB as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

TargetSubstance-P receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50002653(CHEMBL419500 | ((2R,3S)-2-Benzhydryl-1-aza-bicyclo...)
Affinity DataIC50: 10nMAssay Description:Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50079412((NKB)Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH2 |...)
Affinity DataIC50: 10nMAssay Description:Tested for binding affinity for human NK3 receptor expressed in CHO cells by using [125I][MePhe]-NKB as radioligand,More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

TargetSubstance-P receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50422072(CHEMBL140123)
Affinity DataIC50: 10nMAssay Description:Binding affinity towards tachykinin receptor 1 in human IM9 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetSubstance-P receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50079412((NKB)Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH2 |...)
Affinity DataIC50: 13nMAssay Description:Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

TargetSubstance-P receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50422074(CHEMBL344217)
Affinity DataIC50: 13nMAssay Description:Binding affinity towards tachykinin receptor 1 in human IM9 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50282774({(S)-1-[(R)-1-(8-Carbamoyl-octylcarbamoyl)-2-pheny...)
Affinity DataIC50: 15nMAssay Description:Binding affinity for NK3 receptor binding sites in guinea pig cortical membranes by using [125I][MePhe7]-NKB as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50050649({(S)-1-[(R)-1-Methyl-2-phenyl-1-(7-ureido-heptylca...)
Affinity DataIC50: 16nMAssay Description:Tested for binding affinity for human NK3 receptor expressed in CHO cells by using [125I][MePhe]-NKB as radioligand,More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

TargetSubstance-P receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50422081(CHEMBL138150)
Affinity DataIC50: 16nMAssay Description:Binding affinity towards tachykinin receptor 1 in human IM9 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50422060(CHEMBL139471)
Affinity DataIC50: 18nMAssay Description:Binding affinity towards tachykinin receptor 1 in human IM9 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50422063(CHEMBL342924)
Affinity DataIC50: 19nMAssay Description:Binding affinity towards tachykinin receptor 1 in human IM9 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50422066(CHEMBL342044)
Affinity DataIC50: 19nMAssay Description:Binding affinity towards tachykinin receptor 1 in human IM9 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50422077(CHEMBL342260)
Affinity DataIC50: 20nMAssay Description:Binding affinity towards tachykinin receptor 1 in human IM9 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50052524((S)-N-((S)-1-{[(S)-1-({[(S)-1-((S)-1-Carbamoyl-3-m...)
Affinity DataIC50: 21nMAssay Description:Tested for binding affinity for human NK3 receptor expressed in CHO cells by using [125I][MePhe]-NKB as radioligand,More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

TargetNeuromedin-K receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50282782({(S)-1-[(R)-1-(8-Hydroxy-octylcarbamoyl)-2-phenyl-...)
Affinity DataIC50: 22nMAssay Description:Binding affinity for NK3 receptor binding sites in guinea pig cortical membranes by using [125I][MePhe7]-NKB as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50282782({(S)-1-[(R)-1-(8-Hydroxy-octylcarbamoyl)-2-phenyl-...)
Affinity DataIC50: 22nMAssay Description:Binding affinity for NK3 receptor binding sites in guinea pig cortical membranes by using [125I][MePhe7]-NKB as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

TargetSubstance-P receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50422075(CHEMBL138146)
Affinity DataIC50: 22nMAssay Description:Binding affinity towards tachykinin receptor 1 in human IM9 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50422057(CHEMBL140768)
Affinity DataIC50: 27nMAssay Description:Binding affinity towards tachykinin receptor 1 in human IM9 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50282775((S)-2-[2-((S)-2-{(S)-2-[2-(4-Hydroxy-phenyl)-acety...)
Affinity DataIC50: 28nMAssay Description:Tested for binding affinity for human NK3 receptor expressed in CHO cells by using [125I][MePhe]-NKB as radioligand,More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

TargetSubstance-P receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50422065(CHEMBL335106)
Affinity DataIC50: 29nMAssay Description:Binding affinity towards tachykinin receptor 1 in human IM9 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
LigandPNGBDBM24182(4-amino-3-(4-chlorophenyl)butanoic acid | CHEMBL70...)
Affinity DataIC50: 30nMAssay Description:In vitro displacement of [3H]GABA from Gamma-aminobutyric acid type B receptor sites in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetSubstance-P receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50001447(His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2(Neurok...)
Affinity DataIC50: 31nMAssay Description:Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

TargetSubstance-P receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50280464([(2R,3R)-2-(2,2-Diphenyl-ethyl)-1-aza-bicyclo[2.2....)
Affinity DataIC50: 33nMAssay Description:Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

TargetSubstance-P receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50422067(CHEMBL134737)
Affinity DataIC50: 33nMAssay Description:Binding affinity towards tachykinin receptor 1 in human IM9 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50422059(CHEMBL139977)
Affinity DataIC50: 35nMAssay Description:Binding affinity towards tachykinin receptor 1 in human IM9 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetSubstance-P receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50280466([(2R,3R)-2-(2,2-Diphenyl-ethyl)-1-aza-bicyclo[2.2....)
Affinity DataIC50: 37nMAssay Description:Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50282774({(S)-1-[(R)-1-(8-Carbamoyl-octylcarbamoyl)-2-pheny...)
Affinity DataIC50: 39nMAssay Description:Tested for binding affinity for human NK3 receptor expressed in CHO cells by using [125I][MePhe]-NKB as radioligand,More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

TargetSubstance-P receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50422071(CHEMBL341681)
Affinity DataIC50: 43nMAssay Description:Binding affinity towards tachykinin receptor 1 in human IM9 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetSubstance-P receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50280470(Benzyl-[(2R,3R)-2-(2,2-diphenyl-ethyl)-1-aza-bicyc...)
Affinity DataIC50: 52nMAssay Description:Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

LigandPNGBDBM24183(4-amino-n-[2,3-3H]butyric acid | cid_119 | Gamma-A...)
Affinity DataIC50: 60nMAssay Description:In vitro displacement of [3H]GABA from Gamma-aminobutyric acid type B receptor sites in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article
PDB3D3D Structure (crystal)
TargetSubstance-P receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50079412((NKB)Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH2 |...)
Affinity DataIC50: 69nMAssay Description:Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50282777({(S)-1-[1-(8-Hydroxy-octylcarbamoyl)-2-phenyl-ethy...)
Affinity DataIC50: 92nMAssay Description:Tested for binding affinity for human NK3 receptor expressed in CHO cells by using [125I][MePhe]-NKB as radioligand,More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

TargetSubstance-P receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50422080(CHEMBL139017)
Affinity DataIC50: 98nMAssay Description:Binding affinity towards tachykinin receptor 1 in human IM9 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50282783({(S)-1-[1-(8-Methoxy-octylcarbamoyl)-2-phenyl-ethy...)
Affinity DataIC50: 102nMAssay Description:Tested for binding affinity for human NK3 receptor expressed in CHO cells by using [125I][MePhe]-NKB as radioligand,More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

TargetSubstance-P receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50280458((2-Chloro-benzyl)-[(2R,3R)-2-(2,2-diphenyl-ethyl)-...)
Affinity DataIC50: 110nMAssay Description:Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

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