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Found 55 with Last Name = 'mäder' and Initial = 'p'
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM50556029(CHEMBL4759667)
Affinity DataIC50:  0.0250nMAssay Description:Inhibition of human platelets derived PDE5 using [3H]-cGMP as substrate incubated for 60 min by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM50088373(CHEBI:46295 | Vardenafil | cid_110634)
Affinity DataIC50:  0.0290nMAssay Description:Inhibition of human platelets derived PDE5 using [3H]-cGMP as substrate incubated for 60 min by scintillation proximity assayMore data for this Ligand-Target Pair
TargetNeutrophil elastase(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM50120437(CHEMBL3617973)
Affinity DataIC50:  0.0650nMAssay Description:Inhibition of human neutrophil elastase using MeOSuc-AAPV-AMC as substrate measured after 60 mins by fluorescence methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM312923(5-But-2-ynyloxy-pyrazine-2-carboxylic acid [3-((3R...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of BACE1 in HEK293 cells harboring APP assessed as reduction in amyloidbeta 40 level measured after 18 to 20 hrs by AlphaLISA AssayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM50556037(CHEMBL4744163)
Affinity DataIC50:  0.25nMAssay Description:Inhibition of human neutrophil elastase using MeOSuc-AAPV-AMC as substrate measured after 60 mins by fluorescence methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM50556043(CHEMBL4740873)
Affinity DataIC50:  0.590nMAssay Description:Inhibition of BACE1 in HEK293 cells harboring APP assessed as reduction in amyloidbeta 40 level measured after 18 to 20 hrs by AlphaLISA AssayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM50556042(CHEMBL4740455)
Affinity DataIC50:  0.990nMAssay Description:Inhibition of BACE1 in HEK293 cells harboring APP assessed as reduction in amyloidbeta 40 level measured after 18 to 20 hrs by AlphaLISA AssayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM50556031(CHEMBL4782243)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of wild type ESR1 (unknown origin) by transactivation assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM50556030(CHEMBL4760678)
Affinity DataIC50:  2nMAssay Description:Inhibition of wild type ESR1 (unknown origin) by transactivation assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM50556032(CHEMBL4748292)
Affinity DataIC50:  2nMAssay Description:Inhibition of GST-tagged recombinant human CDK1/GST-tagged human cyclin B expressed in Sf-9 cells incubated for 10 mins by scintillation counting met...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM50556040(CHEMBL4796231)
Affinity DataIC50:  2nMAssay Description:Inhibition of BACE1 in HEK293 cells harboring APP assessed as reduction in amyloidbeta 40 level measured after 18 to 20 hrs by AlphaLISA AssayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM50556032(CHEMBL4748292)
Affinity DataIC50:  3nMAssay Description:Inhibition of GST-tagged recombinant human CDK2/GST-tagged human cyclin E expressed in Sf-9 cells incubated for 10 mins by scintillation counting met...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM50461084(CHEMBL4225088)
Affinity DataIC50:  3.20nMAssay Description:Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as reduction in Th17 level incubated for 5 days by MSD electrochemilumin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM50553480(CHEMBL4741442)
Affinity DataIC50:  4nMAssay Description:Inhibition of GST-tagged recombinant human CDK2/GST-tagged human cyclin E expressed in Sf-9 cells incubated for 10 mins by scintillation counting met...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM50556034(CHEMBL4762845)
Affinity DataIC50:  4nMAssay Description:Inhibition of recombinant full length His-tagged human CDK9/cyclin T1 expressed in baculovirus expression system using biotinylated peptide biotin-Tt...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM50468265(CHEMBL4282338)
Affinity DataIC50:  5nMAssay Description:Inhibition of CDK9/Cyclin T1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM50468265(CHEMBL4282338)
Affinity DataIC50:  7nMAssay Description:Inhibition of GST-tagged recombinant human CDK1/GST-tagged human cyclin B expressed in Sf-9 cells incubated for 10 mins by scintillation counting met...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM6145(US8802686, 2 | US8802686, C2)
Affinity DataIC50:  8nMAssay Description:Inhibition of GST-tagged recombinant human CDK2/GST-tagged human cyclin E expressed in Sf-9 cells incubated for 10 mins by scintillation counting met...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM50556035(CHEMBL4746458)
Affinity DataIC50:  8.80nMAssay Description:Inhibition of human DPP4 expressed in baculovirus expression system using Gly-Pro-AMC as substrate by fluorometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM50468265(CHEMBL4282338)
Affinity DataIC50:  9nMAssay Description:Inhibition of GST-tagged recombinant human CDK2/GST-tagged human cyclin E expressed in Sf-9 cells incubated for 10 mins by scintillation counting met...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM6145(US8802686, 2 | US8802686, C2)
Affinity DataIC50:  9nMAssay Description:Inhibition of GST-tagged recombinant human CDK1/GST-tagged human cyclin B expressed in Sf-9 cells incubated for 10 mins by scintillation counting met...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM50468265(CHEMBL4282338)
Affinity DataIC50:  11nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM50553488(CHEMBL4743691)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant full length His-tagged human CDK9/cyclin T1 expressed in baculovirus expression system using biotinylated peptide biotin-Tt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM50528818(CHEMBL4439321)
Affinity DataIC50:  13nMAssay Description:Inhibition of recombinant full length His-tagged human CDK9/cyclin T1 expressed in baculovirus expression system using biotinylated peptide biotin-Tt...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM50556036(CHEMBL4776573)
Affinity DataIC50:  18nMAssay Description:Inhibition of human DPP4 expressed in baculovirus expression system using Gly-Pro-AMC as substrate by fluorometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM50553489(CHEMBL4742789)
Affinity DataIC50:  24nMAssay Description:Inhibition of recombinant full length His-tagged human CDK9/cyclin T1 expressed in baculovirus expression system using biotinylated peptide biotin-Tt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM50556039(CHEMBL4797263)
Affinity DataIC50:  27nMAssay Description:Inhibition of CYP24A1 (unknown origin) expressed in Chinese hamster V79 cells using [3H-1beta]-1alpha,25(OH)2D3 as substrate preincubated for 30 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM50556041(CHEMBL4779761)
Affinity DataIC50:  28nMAssay Description:Inhibition of BACE1 in HEK293 cells harboring APP assessed as reduction in amyloidbeta 40 level measured after 18 to 20 hrs by AlphaLISA AssayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM50556038(CHEMBL389014)
Affinity DataIC50:  28nMAssay Description:Inhibition of human CYP24A1 expressed in Chinese hamster V79 cells using [3H-1beta]-1alpha,25(OH)2D3 as substrate preincubated for 10 mins followed b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM50556038(CHEMBL389014)
Affinity DataIC50:  28nMAssay Description:Inhibition of human CYP24A1 expressed in Chinese hamster V79 cells using [3H-1beta]-1alpha,25(OH)2D3 as substrate preincubated for 10 mins followed b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM50158486((1R,3S,5Z)-5-{2-[(1R,3aS,4E,7aR)-1-[(2R)-4-(benzen...)
Affinity DataIC50:  28nMAssay Description:Inhibition of human CYP24A1 expressed in Chinese hamster V79 cells using [3H-1beta]-1alpha,25(OH)2D3 as substrate preincubated for 10 mins followed b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM50556032(CHEMBL4748292)
Affinity DataIC50:  32nMAssay Description:Inhibition of GST-tagged recombinant human VEGFR2 expressed in Sf-9 cells incubated for 10 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataIC50:  33nMAssay Description:Displacement of tetra-acetylated Histone H4 peptide from BRD4 (unknown origin) incubated for 1 hr by FRET analysisMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM205429( (R)-JQ1 (3) | US10407441, Compound (R)-JQ1 | US10...)
Affinity DataIC50:  33nMAssay Description:Inhibition of human His-tagged BRD4 bromodomain2 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells using H4K5acK8acK12acK16ac as substrate prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM185581(US9156848, 2)
Affinity DataIC50:  34nMAssay Description:Inhibition of human DPP4 expressed in baculovirus expression system using Gly-Pro-AMC as substrate by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM50553480(CHEMBL4741442)
Affinity DataIC50:  34nMAssay Description:Inhibition of GST-tagged recombinant human VEGFR2 expressed in Sf-9 cells incubated for 10 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM185582(US9156848, 3)
Affinity DataIC50:  37nMAssay Description:Inhibition of human DPP4 expressed in baculovirus expression system using Gly-Pro-AMC as substrate by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM180805(US9133171, 10 | US9133171, 15 | US9133171, 16)
Affinity DataIC50:  37nMAssay Description:Inhibition of recombinant full length His-tagged human CDK9/cyclin T1 expressed in baculovirus expression system using biotinylated peptide biotin-Tt...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM50553480(CHEMBL4741442)
Affinity DataIC50:  50nMAssay Description:Inhibition of GST-tagged recombinant human CDK1/GST-tagged human cyclin B expressed in Sf-9 cells incubated for 10 mins by scintillation counting met...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM205429( (R)-JQ1 (3) | US10407441, Compound (R)-JQ1 | US10...)
Affinity DataIC50:  77nMAssay Description:Inhibition of human His-tagged BRD4 bromodomain1 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells using H4K5acK8acK12acK16ac as substrate prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM50556033(CHEMBL4793497)
Affinity DataIC50:  104nMAssay Description:Inhibition of recombinant full length His-tagged human CDK9/cyclin T1 expressed in baculovirus expression system using biotinylated peptide biotin-Tt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM50468265(CHEMBL4282338)
Affinity DataIC50:  163nMAssay Description:Inhibition of GST-tagged recombinant human VEGFR2 expressed in Sf-9 cells incubated for 10 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM8610(1-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imi...)
Affinity DataIC50:  300nMAssay Description:Inhibition of human CYP24A1 expressed in Chinese hamster V79 cells using [3H-1beta]-1alpha,25(OH)2D3 as substrate preincubated for 10 mins followed b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM6145(US8802686, 2 | US8802686, C2)
Affinity DataIC50:  477nMAssay Description:Inhibition of GST-tagged recombinant human VEGFR2 expressed in Sf-9 cells incubated for 10 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM50553480(CHEMBL4741442)
Affinity DataIC50:  514nMAssay Description:Inhibition of human carbonic anhydrase 2 using 4-nitrophenyl acetate as substrate by spectrophotometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
Target25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM50556038(CHEMBL389014)
Affinity DataIC50:  554nMAssay Description:Inhibition of CYP27B in human SW900 cells using 3H-(23,24)-25-(OH)D3 as substrate incubated for 5 hrs by HPLC methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSterol 26-hydroxylase, mitochondrial(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM50556038(CHEMBL389014)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of CYP27A1 (unknown origin) expressed in Chinese hamster V79 cells using 1alpha-(OH)D3 as substrate measured after 24 hrs by HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM50553488(CHEMBL4743691)
Affinity DataIC50:  1.08E+3nMAssay Description:Inhibition of recombinant GST-tagged human CDK2/GST-tagged cyclin E expressed in sf9 cells using biotinylated peptide biotin-Ttds-YISPLKSPYKISEG as s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM50528818(CHEMBL4439321)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of recombinant GST-tagged human CDK2/GST-tagged cyclin E expressed in sf9 cells using biotinylated peptide biotin-Ttds-YISPLKSPYKISEG as s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM50556034(CHEMBL4762845)
Affinity DataIC50:  2.92E+3nMAssay Description:Inhibition of recombinant GST-tagged human CDK2/GST-tagged cyclin E expressed in sf9 cells using biotinylated peptide biotin-Ttds-YISPLKSPYKISEG as s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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