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Found 104 with Last Name = 'maguire' and Initial = 'rj'
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305346((S)-2-(2-aminoethoxy)-3-(1-phenyl-1H-imidazol-4-yl...)
Affinity DataKi:  3.5nMAssay Description:Inhibition of active form of human recombinant TAFI assessed as substrate turnover every 15 seconds for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305347((S)-2-(2-aminoethoxy)-3-(1-(4-tert-butylphenyl)-1H...)
Affinity DataKi:  5.70nMAssay Description:Inhibition of active form of human recombinant TAFI assessed as substrate turnover every 15 seconds for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305351((S)-2-((R)-1-aminopropan-2-yloxy)-3-(1-(pyridin-2-...)
Affinity DataKi:  5.80nMAssay Description:Inhibition of active form of human recombinant TAFI assessed as substrate turnover every 15 seconds for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305345((S)-2-(2-aminoethoxy)-3-(1-propyl-1H-imidazol-4-yl...)
Affinity DataKi:  6.70nMAssay Description:Inhibition of active form of human recombinant TAFI assessed as substrate turnover every 15 seconds for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305352((S)-2-((R)-1-aminopropan-2-yloxy)-3-(1-phenyl-1H-i...)
Affinity DataKi:  7.5nMAssay Description:Inhibition of active form of human recombinant TAFI assessed as substrate turnover every 15 seconds for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305348((S)-2-(2-aminoethoxy)-3-(1-(2-cyclohexylethyl)-1H-...)
Affinity DataKi:  8.20nMAssay Description:Inhibition of active form of human recombinant TAFI assessed as substrate turnover every 15 seconds for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305349((+/-)-2-(2-aminoethoxy)-3-(1-butyl-1H-imidazol-4-y...)
Affinity DataKi:  15nMAssay Description:Inhibition of active form of human recombinant TAFI assessed as substrate turnover every 15 seconds for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226610((2S)-5-AMINO-2-[(1-PROPYL-1H-IMIDAZOL-4-YL)METHYL]...)
Affinity DataKi:  16nMAssay Description:Inhibition of active form of human recombinant TAFI assessed as substrate turnover every 15 seconds for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305346((S)-2-(2-aminoethoxy)-3-(1-phenyl-1H-imidazol-4-yl...)
Affinity DataKi:  27nMAssay Description:Inhibition of human pancreatic carboxypeptidase BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305348((S)-2-(2-aminoethoxy)-3-(1-(2-cyclohexylethyl)-1H-...)
Affinity DataKi:  27nMAssay Description:Inhibition of human pancreatic carboxypeptidase BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305347((S)-2-(2-aminoethoxy)-3-(1-(4-tert-butylphenyl)-1H...)
Affinity DataKi:  49nMAssay Description:Inhibition of human pancreatic carboxypeptidase BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305350((+/-)-2-(2-aminoethoxy)-3-(1-o-tolyl-1H-imidazol-4...)
Affinity DataKi:  65nMAssay Description:Inhibition of active form of human recombinant TAFI assessed as substrate turnover every 15 seconds for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226606((S)-2-(2-aminoethylamino)-3-(1-propyl-1H-imidazol-...)
Affinity DataKi:  150nMAssay Description:Inhibition of active form of human recombinant TAFI assessed as substrate turnover every 15 seconds for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226610((2S)-5-AMINO-2-[(1-PROPYL-1H-IMIDAZOL-4-YL)METHYL]...)
Affinity DataKi:  206nMAssay Description:Inhibition of human pancreatic carboxypeptidase BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305345((S)-2-(2-aminoethoxy)-3-(1-propyl-1H-imidazol-4-yl...)
Affinity DataKi:  238nMAssay Description:Inhibition of human pancreatic carboxypeptidase BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305352((S)-2-((R)-1-aminopropan-2-yloxy)-3-(1-phenyl-1H-i...)
Affinity DataKi:  240nMAssay Description:Inhibition of human pancreatic carboxypeptidase BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305351((S)-2-((R)-1-aminopropan-2-yloxy)-3-(1-(pyridin-2-...)
Affinity DataKi:  265nMAssay Description:Inhibition of human pancreatic carboxypeptidase BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305349((+/-)-2-(2-aminoethoxy)-3-(1-butyl-1H-imidazol-4-y...)
Affinity DataKi:  360nMAssay Description:Inhibition of human pancreatic carboxypeptidase BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305353((+/-)-2-(2-(methylamino)ethoxy)-3-(1-propyl-1H-imi...)
Affinity DataKi:  407nMAssay Description:Inhibition of active form of human recombinant TAFI assessed as substrate turnover every 15 seconds for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305354((R)-2-(2-aminoethoxy)-3-(1-propyl-1H-imidazol-4-yl...)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of active form of human recombinant TAFI assessed as substrate turnover every 15 seconds for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226606((S)-2-(2-aminoethylamino)-3-(1-propyl-1H-imidazol-...)
Affinity DataKi:  1.16E+3nMAssay Description:Inhibition of human pancreatic carboxypeptidase BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305350((+/-)-2-(2-aminoethoxy)-3-(1-o-tolyl-1H-imidazol-4...)
Affinity DataKi:  2.72E+3nMAssay Description:Inhibition of human pancreatic carboxypeptidase BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305353((+/-)-2-(2-(methylamino)ethoxy)-3-(1-propyl-1H-imi...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human pancreatic carboxypeptidase BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305354((R)-2-(2-aminoethoxy)-3-(1-propyl-1H-imidazol-4-yl...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human pancreatic carboxypeptidase BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 5 member 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50342885((1S,2S,3S,4R,5S)-5-[4-Chloro-3-(4-ethoxybenzyl)phe...)
Affinity DataIC50:  0.877nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of methyl alpha-D-glucopyranoside uptake after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 5 member 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50342887((1S,2S,3S,4R,5S)-5-[4-Chloro-3-(4-methoxybenzyl)ph...)
Affinity DataIC50:  0.882nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of methyl alpha-D-glucopyranoside uptake after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50308469((2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-methoxybenzyl)ph...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 5 member 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50342889((1S,2S,3S,4R,5S)-1-(Hydroxymethyl)-5-[3-(4-methoxy...)
Affinity DataIC50:  1.07nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of methyl alpha-D-glucopyranoside uptake after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 5 member 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50342888((1S,2S,3S,4R,5S)-5-[3-(4-Ethoxybenzyl)-4-methylphe...)
Affinity DataIC50:  1.11nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of methyl alpha-D-glucopyranoside uptake after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50342885((1S,2S,3S,4R,5S)-5-[4-Chloro-3-(4-ethoxybenzyl)phe...)
Affinity DataIC50:  1.15nMAssay Description:Inhibition of rat SGLT2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM20880((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313364((2S,3R,4R,5S,6R)-2-(3-(4-ethylbenzyl)-4-methylphen...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313371((2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-methoxybenzyl)ph...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313374((5S,6R,7R,8S)-5-(3-(4-ethylbenzyl)-4-methylphenyl)...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313367((6S,7R,8R,9S)-6-(3-(4-ethylbenzyl)-4-methylphenyl)...)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313384((2S,3R,4R,5S,6S)-2-(4-chloro-3-(4-methoxybenzyl)ph...)
Affinity DataIC50:  5.10nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313368((6S,7R,8R,9S)-6-(3-(4-methoxybenzyl)-4-methylpheny...)
Affinity DataIC50:  6.60nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 5 member 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313368((6S,7R,8R,9S)-6-(3-(4-methoxybenzyl)-4-methylpheny...)
Affinity DataIC50:  6.98nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of methyl alpha-D-glucopyranoside uptake after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313375((5S,6R,7R,8S)-5-(3-(4-methoxybenzyl)-4-methylpheny...)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313377((6S,7R,8R,9S)-6-[3-(4-Ethyl-benzyl)-4-methyl-pheny...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313381((2S,3R,4S,6S)-2-(4-chloro-3-(4-methoxybenzyl)pheny...)
Affinity DataIC50:  21nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313369((6S,7R,8R,9S)-6-(4-chloro-3-(4-methoxybenzyl)pheny...)
Affinity DataIC50:  23nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313370((6S,7R,8R,9S)-6-(4-chloro-3-(4-ethoxybenzyl)phenyl...)
Affinity DataIC50:  32nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 5 member 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50342886((1S,2S,3S,4S,5S)-5-[4-Chloro-3-(4-methoxybenzyl)-p...)
Affinity DataIC50:  43.1nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of methyl alpha-D-glucopyranoside uptake after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313373((5R,7S,8R,9R,10S)-7-(3-(4-ethylbenzyl)-4-methylphe...)
Affinity DataIC50:  53nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313372((3S,4R,5R,6S)-6-(4-chloro-3-(4-methoxybenzyl)pheny...)
Affinity DataIC50:  59nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313371((2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-methoxybenzyl)ph...)
Affinity DataIC50:  73nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 5 member 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50342884((1S,2S,3S,4S,5S)-5-[4-Chloro-3-(4-ethoxybenzyl)-ph...)
Affinity DataIC50:  89.9nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of methyl alpha-D-glucopyranoside uptake after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313382((2S,3R,4R,5R,6R)-2-(3-(4-ethylbenzyl)-4-methylphen...)
Affinity DataIC50:  139nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313378((2R,3S,4S,5R,6S)-6-(4-chloro-3-(4-methoxybenzyl)ph...)
Affinity DataIC50:  140nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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