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Found 402 with Last Name = 'unger' and Initial = 'l'
TargetVasopressin V1b receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50345133((S)-1-((R)-5-chloro-3-(2-methoxy-5-(pyrrolidin-1-y...)
Affinity DataKi:  0.0300nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50345134((S)-1-((R)-5-chloro-3-(2-methoxy-5-((4-methylpiper...)
Affinity DataKi:  0.0300nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50345131((S)-1-((R)-5-chloro-3-(2-methoxy-4-((4-methylpiper...)
Affinity DataKi:  0.0400nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50345130((S)-1-((R)-5-chloro-3-(2-methoxy-4-(pyrrolidin-1-y...)
Affinity DataKi:  0.0800nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50175484(3-[2-(4-isoquinolin-8-yl-piperazin-1-yl)-ethyl]-7-...)
Affinity DataKi:  0.100nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Basf

Curated by ChEMBL
LigandPNGBDBM50050807(3-Methoxy-2-(4-methoxy-6-methyl-pyrimidin-2-yloxy)...)
Affinity DataKi:  0.120nMAssay Description:Binding affinity of the compound towards human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50175479(7-methyl-3-[2-(4-quinolin-8-yl-piperazin-1-yl)-eth...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [35S]GTPgammaS from human recombinant 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50345132((S)-1-((R)-5-chloro-1-(2,4-dimethoxyphenylsulfonyl...)
Affinity DataKi:  0.260nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50175479(7-methyl-3-[2-(4-quinolin-8-yl-piperazin-1-yl)-eth...)
Affinity DataKi:  0.300nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50175484(3-[2-(4-isoquinolin-8-yl-piperazin-1-yl)-ethyl]-7-...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [35S]GTPgammaS from human recombinant 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50175485(3-[2-(4-benzo[b]thiophen-7-yl-piperazin-1-yl)-ethy...)
Affinity DataKi:  0.400nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50175485(3-[2-(4-benzo[b]thiophen-7-yl-piperazin-1-yl)-ethy...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [35S]GTPgammaS from human recombinant 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Basf

Curated by ChEMBL
LigandPNGBDBM50050793(3-Methoxy-2-(4-methoxy-6,7-dihydro-5H-cyclopentapy...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity of the compound towards human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Basf

Curated by ChEMBL
LigandPNGBDBM50079431(3-(3,4-Dimethoxy-phenoxy)-2-(4,6-dimethyl-pyrimidi...)
Affinity DataKi:  0.480nMAssay Description:Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50175467(3-[2-(4-isoquinolin-1-yl-piperazin-1-yl)-ethyl]-7-...)
Affinity DataKi:  0.5nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50175463(3-{2-[4-(3-chloro-2-methoxy-phenyl)-piperazin-1-yl...)
Affinity DataKi:  0.5nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50175477(3-{2-[4-(2,3-dihydro-benzofuran-7-yl)-piperazin-1-...)
Affinity DataKi:  0.5nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50175489(7-methyl-3-[2-(4-naphthalen-1-yl-piperazin-1-yl)-e...)
Affinity DataKi:  0.5nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50175477(3-{2-[4-(2,3-dihydro-benzofuran-7-yl)-piperazin-1-...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [35S]GTPgammaS from human recombinant 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50175460(3-{2-[4-(2-isopropoxy-phenyl)-piperazin-1-yl]-ethy...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [35S]GTPgammaS from human recombinant 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50175489(7-methyl-3-[2-(4-naphthalen-1-yl-piperazin-1-yl)-e...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [35S]GTPgammaS from human recombinant 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Basf

Curated by ChEMBL
LigandPNGBDBM50050789(2-(4-Ethyl-6-methyl-pyrimidin-2-yloxy)-3-methoxy-3...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity of the compound towards human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50175486(3-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl}-...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [35S]GTPgammaS from human recombinant 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50175467(3-[2-(4-isoquinolin-1-yl-piperazin-1-yl)-ethyl]-7-...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [35S]GTPgammaS from human recombinant 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50181170(1-(4-(4-(2-tert-butyl-6-(trifluoromethyl)pyrimidin...)
Affinity DataKi:  0.800nMAssay Description:Binding affinity to cloned human dopamine D3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50176440(1-(4-(4-(2-tert-butyl-6-(trifluoromethyl)pyrimidin...)
Affinity DataKi:  0.800nMAssay Description:Binding affinity to human cloned dopamine D3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50345129((S)-1-((R)-5-chloro-1-(2,4-dimethoxyphenylsulfonyl...)
Affinity DataKi:  0.810nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50175473(3-[2-(4-isoquinolin-5-yl-piperazin-1-yl)-ethyl]-7-...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [35S]GTPgammaS from human recombinant 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50175470(7-methyl-3-{2-[4-(2-phenoxy-phenyl)-piperazin-1-yl...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [35S]GTPgammaS from human recombinant 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Basf

Curated by ChEMBL
LigandPNGBDBM50050800(3-Methoxy-2-(4-methoxy-5,6-dihydro-furo[2,3-d]pyri...)
Affinity DataKi:  0.900nMAssay Description:Binding affinity of the compound towards human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50175473(3-[2-(4-isoquinolin-5-yl-piperazin-1-yl)-ethyl]-7-...)
Affinity DataKi:  0.900nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50181161(3-(4-(4-(2-tert-butyl-6-(trifluoromethyl)pyrimidin...)
Affinity DataKi:  0.900nMAssay Description:Binding affinity to cloned human dopamine D3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 5A(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50175465(7-methyl-3-[2-(4-quinolin-4-yl-piperazin-1-yl)-eth...)
Affinity DataKi: >1nMAssay Description:Inhibitory activity against 5HT5A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Basf

Curated by ChEMBL
LigandPNGBDBM50050806(2-(4,6-Dimethyl-pyrimidin-2-yloxy)-3-methoxy-3,3-d...)
Affinity DataKi:  1nMAssay Description:Binding affinity of the compound towards human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Basf

Curated by ChEMBL
LigandPNGBDBM50050796(2-(4,6-Diethyl-pyrimidin-2-yloxy)-3-methoxy-3,3-di...)
Affinity DataKi:  1nMAssay Description:Binding affinity of the compound towards human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50175470(7-methyl-3-{2-[4-(2-phenoxy-phenyl)-piperazin-1-yl...)
Affinity DataKi:  1.10nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50181164(1-(4-(4-(2-tert-butyl-6-(trifluoromethyl)pyrimidin...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity to cloned human dopamine D3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50466882(CHEMBL4280894)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cell membranes after 60 mins by TopCount microplate scintillation counti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50175471(3-[2-(4-biphenyl-2-yl-piperazin-1-yl)-ethyl]-7-met...)
Affinity DataKi:  1.10nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50175461(3-[2-(4-isoquinolin-4-yl-piperazin-1-yl)-ethyl]-7-...)
Affinity DataKi:  1.18nMAssay Description:Inhibitory activity against dopamine D3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50175465(7-methyl-3-[2-(4-quinolin-4-yl-piperazin-1-yl)-eth...)
Affinity DataKi:  1.20nMAssay Description:Inhibitory activity against 5HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50175461(3-[2-(4-isoquinolin-4-yl-piperazin-1-yl)-ethyl]-7-...)
Affinity DataKi:  1.20nMAssay Description:Inhibitory activity against dopamine D2(long) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50175464(3-{2-[4-(2-benzyloxy-phenyl)-piperazin-1-yl]-ethyl...)
Affinity DataKi:  1.20nMAssay Description:Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50345139((R)-5-chloro-3-(2-methoxy-5-(pyrrolidin-1-ylmethyl...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50345142((R)-5-chloro-3-(2-methoxy-5-((4-methylpiperazin-1-...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50177356(1-(4-(4-(2-tert-butyl-6-(trifluoromethyl)pyrimidin...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity to human cloned dopamine D3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50466872(CHEMBL4281098)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cell membranes after 60 mins by TopCount microplate scintillation counti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50466872(CHEMBL4281098)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cell membranes after 60 mins by TopCount microplate scintillation counti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVasopressin V1b receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50345143((2S,4R)-1-((R)-5-chloro-1-(2,4-dimethoxyphenylsulf...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Abbott GmbH & Co. KG

Curated by ChEMBL
LigandPNGBDBM50175465(7-methyl-3-[2-(4-quinolin-4-yl-piperazin-1-yl)-eth...)
Affinity DataKi:  1.30nMAssay Description:Inhibitory activity against dopamine D3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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