Affinity DataIC50: 0.310nMAssay Description:Inhibition of Staphylococcus aureus FabI assessed as inhibition of bacterial growth by measuring the NADH consumption rate at 20 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.330nMAssay Description:Inhibition of Staphylococcus aureus FabI assessed as inhibition of bacterial growth by measuring the NADH consumption rate at 20 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.350nMAssay Description:Inhibition of Staphylococcus aureus FabI assessed as inhibition of bacterial growth by measuring the NADH consumption rate at 20 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.370nMAssay Description:Inhibition of Staphylococcus aureus FabI assessed as inhibition of bacterial growth by measuring the NADH consumption rate at 20 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of Staphylococcus aureus recombinant FabI using trans-2-octenoyl N-acetylcysteamine thioester as substrate preincubated for 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of Staphylococcus aureus FabI in the presence of NADH using crotonyl CoA as substrate by measuring NADH consumption rateMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of Staphylococcus aureus ATCC 29213 FabI in the presence of NADH using crotonyl CoA as substrate by measuring NADH consumption rateMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of Staphylococcus aureus recombinant FabI using trans-2-octenoyl N-acetylcysteamine thioester as substrate preincubated for 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of Staphylococcus aureus recombinant FabI using trans-2-octenoyl N-acetylcysteamine thioester as substrate preincubated for 60 minsMore data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataIC50: 13nMpH: 6.5 T: 2°CAssay Description:Compound inhibitory activity of FabI enzyme is measured in vitro by the IC5 so determination using a fluorescence based assay.The protein FabI from S...More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of Staphylococcus aureus FabI assessed as inhibition of bacterial growth by measuring the NADH consumption rate at 20 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of Staphylococcus aureus FabIMore data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of Staphylococcus aureus recombinant FabI using trans-2-octenoyl N-acetylcysteamine thioester as substrate preincubated for 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMpH: 6.5 T: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of Staphylococcus aureus FabIMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMpH: 6.5 T: 2°CAssay Description:Compound inhibitory activity of FabI enzyme is measured in vitro by the IC5 so determination using a fluorescence based assay.The protein FabI from S...More data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Inhibition of Staphylococcus aureus FabIMore data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Inhibition of Staphylococcus aureus FabIMore data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Inhibition of Staphylococcus aureus recombinant FabI using trans-2-octenoyl N-acetylcysteamine thioester as substrate preincubated for 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Inhibition of Staphylococcus aureus FabIMore data for this Ligand-Target Pair
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI [9-251](Staphylococcus aureus)
Aurigene Discovery Technologies
Curated by ChEMBL
Aurigene Discovery Technologies
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition of Staphylococcus aureus FabI-mediated reduction of enoyl-ACP preincubated for 30 mins measured after 2 hrs by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of Staphylococcus aureus FabIMore data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Inhibition of Staphylococcus aureus recombinant FabI using trans-2-octenoyl N-acetylcysteamine thioester as substrate preincubated for 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 37nMAssay Description:Inhibition of Staphylococcus aureus recombinant FabI using trans-2-octenoyl N-acetylcysteamine thioester as substrate preincubated for 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 41nMpH: 6.5 T: 2°CAssay Description:Compound inhibitory activity of FabI enzyme is measured in vitro by the IC5 so determination using a fluorescence based assay.The protein FabI from S...More data for this Ligand-Target Pair
Affinity DataIC50: 48nMAssay Description:Inhibition of Staphylococcus aureus FabIMore data for this Ligand-Target Pair
Affinity DataIC50: 48nMAssay Description:Inhibition of Staphylococcus aureus recombinant FabI using trans-2-octenoyl N-acetylcysteamine thioester as substrate preincubated for 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 49nMAssay Description:Inhibition of Staphylococcus aureus FabIMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMpH: 6.5 T: 2°CAssay Description:Compound inhibitory activity of FabI enzyme is measured in vitro by the IC5 so determination using a fluorescence based assay.The protein FabI from S...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of Staphylococcus aureus FabIMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMpH: 6.5 T: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMpH: 6.5 T: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
Affinity DataIC50: 56nMAssay Description:Inhibition of Staphylococcus aureus recombinant FabI using trans-2-octenoyl N-acetylcysteamine thioester as substrate preincubated for 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 57nMpH: 6.5 T: 2°CAssay Description:Compound inhibitory activity of FabI enzyme is measured in vitro by the IC5 so determination using a fluorescence based assay.The protein FabI from S...More data for this Ligand-Target Pair
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI [9-251](Staphylococcus aureus)
Aurigene Discovery Technologies
Curated by ChEMBL
Aurigene Discovery Technologies
Curated by ChEMBL
Affinity DataIC50: 58nMAssay Description:Inhibition of Staphylococcus aureus FabI-mediated reduction of enoyl-ACP preincubated for 30 mins measured after 2 hrs by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 59nMAssay Description:Inhibition of Staphylococcus aureus recombinant FabI using trans-2-octenoyl N-acetylcysteamine thioester as substrate preincubated for 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 60nMpH: 6.5 T: 2°CAssay Description:Compound inhibitory activity of FabI enzyme is measured in vitro by the IC5 so determination using a fluorescence based assay.The protein FabI from S...More data for this Ligand-Target Pair
Affinity DataIC50: 60nMpH: 6.5 T: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
Affinity DataIC50: 70nMpH: 6.5 T: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
Affinity DataIC50: 70nMpH: 6.5 T: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
Affinity DataIC50: 71nMAssay Description:Inhibition of Staphylococcus aureus FabIMore data for this Ligand-Target Pair
Affinity DataIC50: 78nMpH: 6.5 T: 2°CAssay Description:Compound inhibitory activity of FabI enzyme is measured in vitro by the IC5 so determination using a fluorescence based assay.The protein FabI from S...More data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Inhibition of Staphylococcus aureus FabI assessed as reduction in inhibition of reduction of trans-2-octenoyl N-acetylcysteamine substrate by spectro...More data for this Ligand-Target Pair
Affinity DataIC50: 81nMpH: 6.5 T: 2°CAssay Description:Compound inhibitory activity of FabI enzyme is measured in vitro by the IC5 so determination using a fluorescence based assay.The protein FabI from S...More data for this Ligand-Target Pair
Affinity DataIC50: 82nMAssay Description:Inhibition of Staphylococcus aureus recombinant FabI using trans-2-octenoyl N-acetylcysteamine thioester as substrate preincubated for 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of Staphylococcus aureus FabI assessed as reduction in inhibition of reduction of trans-2-octenoyl N-acetylcysteamine substrate by spectro...More data for this Ligand-Target Pair
Affinity DataIC50: 110nMpH: 6.5 T: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of Staphylococcus aureus FabI assessed as inhibition of bacterial growth by measuring the NADH consumption rate at 20 minsMore data for this Ligand-Target Pair
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI [9-251](Staphylococcus aureus)
Aurigene Discovery Technologies
Curated by ChEMBL
Aurigene Discovery Technologies
Curated by ChEMBL
Affinity DataIC50: 112nMAssay Description:Inhibition of Staphylococcus aureus FabI-mediated reduction of enoyl-ACP preincubated for 30 mins measured after 2 hrs by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of Staphylococcus aureus FabI assessed as inhibition of bacterial growth by measuring the NADH consumption rate at 20 minsMore data for this Ligand-Target Pair
