Compile Data Set for Download or QSAR
maximum 50k data
Report error Found 459 of ic50 for UniProtKB: P0C6U8
TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50208940(5-bromo-pyridin-3-yl furan-2-carboxylate | 5-bromo...)
Affinity DataIC50:  50nMAssay Description:Inhibition of SARS coronavirus 3C-like proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM32805((5-chloranylpyridin-3-yl) furan-2-carboxylate | (5...)
Affinity DataIC50:  60nMAssay Description:Inhibition of SARS coronavirus 3C-like proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50208942(5-chloropyridin-3-yl 5-(4-chlorophenyl)furan-2-car...)
Affinity DataIC50:  63nMAssay Description:Inhibition of SARS coronavirus 3C-like proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50208939(5-chloro-pyridin-3-yl-1H-indole-2-carboxylate | 5-...)
Affinity DataIC50:  65nMAssay Description:Inhibition of SARS coronavirus 3C-like proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50208941(5-chloropyridin-3-yl benzo[b]thiophene-2-carboxyla...)
Affinity DataIC50:  95nMAssay Description:Inhibition of SARS coronavirus 3C-like proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM582033(Preparation of (2S,4R)-1-((S)-2-(8-(4-(((E)-4-(6-c...)
Affinity DataIC50: <100nMAssay Description:The inhibitory activity of the compounds against SARS-CoV-2 3CLpro was determined using fluorescence resonance energy transfer.10 μL of the comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM582032(Preparation of (2S,4R)-1-((S)-2-(7-(4-(((E)-4-(6-c...)
Affinity DataIC50: <100nMAssay Description:The inhibitory activity of the compounds against SARS-CoV-2 3CLpro was determined using fluorescence resonance energy transfer.10 μL of the comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM582035(Preparation of (2S,4R)-1-((S)-2-(2-(2-(2-(4-(((E)-...)
Affinity DataIC50: <100nMAssay Description:The inhibitory activity of the compounds against SARS-CoV-2 3CLpro was determined using fluorescence resonance energy transfer.10 μL of the comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM582036(Preparation of (2S,4R)-1-((S)-2-(tert-butyl)-14-(4...)
Affinity DataIC50: <100nMAssay Description:The inhibitory activity of the compounds against SARS-CoV-2 3CLpro was determined using fluorescence resonance energy transfer.10 μL of the comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM582031(Preparation of pyrrolidine-2-carboxamide of (2S,4R...)
Affinity DataIC50: <100nMAssay Description:The inhibitory activity of the compounds against SARS-CoV-2 3CLpro was determined using fluorescence resonance energy transfer.10 μL of the comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50007791(CHEMBL3233815 | med.21724, Compound 168)
Affinity DataIC50:  150nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM496258(CVD-0013146 | JOH-MSK-46727e7b-1)
Affinity DataIC50:  161nMAssay Description:Inhibition of SARS-CoV N-terminal 6His-SUMO-tagged 3CL protease expressed in Escherichia coli BL21 (DE3) using Dabcyl-KTSAVLQSGFRKM-Glu-Edans fluorog...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50620678(CHEMBL5436771)
Affinity DataIC50:  165nMAssay Description:Inhibition of SARS-CoV N-terminal 6His-SUMO-tagged 3CL protease expressed in Escherichia coli BL21 (DE3) using Dabcyl-KTSAVLQSGFRKM-Glu-Edans fluorog...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50208943(5-chloropyridin-3-yl benzofuran-2-carboxylate | CH...)
Affinity DataIC50:  170nMAssay Description:Inhibition of SARS coronavirus 3C-like proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50208938(5-chloropyridin-3-yl thiazole-4-carboxylate | 5-ch...)
Affinity DataIC50:  270nMAssay Description:Inhibition of SARS coronavirus 3C-like proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50007789(CHEMBL1173044 | GRL-0667 | N-(2H-1,3-benzodioxol-5...)
Affinity DataIC50:  320nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50208944(5-chloropyridin-3-yl 3-methoxybenzoate | 5-chlorop...)
Affinity DataIC50:  340nMAssay Description:Inhibition of SARS coronavirus 3C-like proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50055218(1-(2-naphthlmethyl) isatin-5-carboxamide | 1-Napht...)
Affinity DataIC50:  370nMAssay Description:Inhibition of SARS CoV 3C-like proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50620674(CHEMBL4590273)
Affinity DataIC50:  383nMAssay Description:Inhibition of SARS-CoV N-terminal 6His-SUMO-tagged 3CL protease expressed in Escherichia coli BL21 (DE3) using Dabcyl-KTSAVLQSGFRKM-Glu-Edans fluorog...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50007788(CHEMBL3233809 | med.21724, Compound 167)
Affinity DataIC50:  390nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM31531(Substituted Benzamide Derivative, 2 | med.21724, C...)
Affinity DataIC50:  460nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50007790(CHEMBL3233814 | med.21724, Compound 169)
Affinity DataIC50:  490nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM582034(US11518759, Compound 7)
Affinity DataIC50:  550nMAssay Description:The inhibitory activity of the compounds against SARS-CoV-2 3CLpro was determined using fluorescence resonance energy transfer.10 μL of the comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM582029(Preparation of (2S,4R)-1-((S)-2-(4-(4-(((E)-4-(6-c...)
Affinity DataIC50:  550nMAssay Description:The inhibitory activity of the compounds against SARS-CoV-2 3CLpro was determined using fluorescence resonance energy transfer.10 μL of the comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM582028(US11518759, Compound 1)
Affinity DataIC50:  550nMAssay Description:The inhibitory activity of the compounds against SARS-CoV-2 3CLpro was determined using fluorescence resonance energy transfer.10 μL of the comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM582030(Preparation of (2S,4R)-1-((S)-2-(5-(4-(((E)-4-(6-c...)
Affinity DataIC50:  550nMAssay Description:The inhibitory activity of the compounds against SARS-CoV-2 3CLpro was determined using fluorescence resonance energy transfer.10 μL of the comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM154574(N-(2H-1,3-benzodioxol-5-ylmethyl)-1-[(1S)-1-(napht...)
Affinity DataIC50:  560nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM31523(Compound 6 | Naphthalene and Benzamide Derivative,...)
Affinity DataIC50:  560nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM31524(5-amino-2-methyl-N-[(1R)-1-(naphthalen-1-yl)ethyl]...)
Affinity DataIC50:  600nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM51317(1,6-dimethylnaphtho[1,2-g][1]benzofuran-10,11-dion...)
Affinity DataIC50:  700nMAssay Description:Inhibition of SARS-CoV PLpro deubiququitination expressed in Escherichia coli BL21 (DE3) using Arg-Leu-Arg-Gly-Gly-AMC as substrate by fluorescence a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM53072((5Z)-3-allyl-5-(3-ethyl-1,3-benzothiazol-2-ylidene...)
Affinity DataIC50:  800nMAssay Description:Inhibition of SARS-CoV PLpro expressed in Escherichia coli BL21 (DE3) using Arg-Leu-Arg-Gly-Gly-AMC as substrate preincubated for 30 mins by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM83922(1,6,6-trimethyl-8,9-dihydro-7H-naphtho[1,2-g][1]be...)
Affinity DataIC50:  800nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM419127(3CLpro inhibitor 6e)
Affinity DataIC50:  900nMAssay Description:The expression and purification of the 3CLpro of MERS-CoV and SARS-CoV were performed by a standard method described previously by our lab (11, 19, 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50167307(1-Benzo[b]thiophen-2-ylmethyl-5-iodo-1H-indole-2,3...)
Affinity DataIC50:  950nMAssay Description:In vitro inhibitory concentration against SARS coronavirus main protease (SARS CoV 3C-like protease)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50167309(1-Benzo[b]thiophen-2-ylmethyl-7-bromo-1H-indole-2,...)
Affinity DataIC50:  980nMAssay Description:In vitro inhibitory concentration SARS coronavirus main protease (SARS CoV 3C-like protease) More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM419128(3CLpro inhibitor 7e)
Affinity DataIC50:  1.00E+3nMAssay Description:The expression and purification of the 3CLpro of MERS-CoV and SARS-CoV were performed by a standard method described previously by our lab (11, 19, 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM419131(3CLpro inhibitor 6j | 3CLpro inhibitor 7j)
Affinity DataIC50:  1.10E+3nMAssay Description:The expression and purification of the 3CLpro of MERS-CoV and SARS-CoV were performed by a standard method described previously by our lab (11, 19, 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50423877(DIHYDROTANSHINONE | Dihydrotanshinone I | acs.jmed...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of SARS-CoV PLpro deubiququitination expressed in Escherichia coli BL21 (DE3) using Arg-Leu-Arg-Gly-Gly-AMC as substrate by fluorescence a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM419131(3CLpro inhibitor 6j | 3CLpro inhibitor 7j)
Affinity DataIC50:  1.20E+3nMAssay Description:The expression and purification of the 3CLpro of MERS-CoV and SARS-CoV were performed by a standard method described previously by our lab (11, 19, 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM31530(2-methyl-5-[(methylamino)methyl]-N-[(1R)-1-(naphth...)
Affinity DataIC50:  1.23E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM429329(acs.jmedchem.1c00409_ST.265 | jm5b01461, Compound ...)
Affinity DataIC50:  1.50E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM83922(1,6,6-trimethyl-8,9-dihydro-7H-naphtho[1,2-g][1]be...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of SARS-CoV PLpro expressed in Escherichia coli BL21 (DE3) using Arg-Leu-Arg-Gly-Gly-AMC as substrate preincubated for 30 mins by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM419124(3CLpro inhibitor 6c)
Affinity DataIC50:  1.70E+3nMAssay Description:The expression and purification of the 3CLpro of MERS-CoV and SARS-CoV were performed by a standard method described previously by our lab (11, 19, 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM419126(3CLpro inhibitor 7c)
Affinity DataIC50:  1.70E+3nMAssay Description:The expression and purification of the 3CLpro of MERS-CoV and SARS-CoV were performed by a standard method described previously by our lab (11, 19, 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50167306(1-Benzo[b]thiophen-2-ylmethyl-7-nitro-1H-indole-2,...)
Affinity DataIC50:  2.00E+3nMAssay Description:In vitro inhibitory concentration against SARS coronavirus main protease (SARS CoV 3C-like protease)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM582499(US11524940, Compound 101)
Affinity DataIC50: <2.00E+3nMAssay Description:Compounds are assayed using standard methods to assess compound activity and IC50. As an exemplary for assessment of the SARS-COV2 Mpro, the C-His6-t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM509781(US11124497, Compound 103 | US11312704, Compound 10...)
Affinity DataIC50: <2.00E+3nMAssay Description:Compounds are assayed using standard methods to assess compound activity and IC50. As an exemplary for assessment of the SARS-COV2 Mpro, the C-His6-t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM509783(US11124497, Compound 129 | US11312704, Compound 12...)
Affinity DataIC50: <2.00E+3nMAssay Description:Compounds are assayed using standard methods to assess compound activity and IC50. As an exemplary for assessment of the SARS-COV2 Mpro, the C-His6-t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM509784(US11124497, Compound 131 | US11312704, Compound 13...)
Affinity DataIC50: <2.00E+3nMAssay Description:Compounds are assayed using standard methods to assess compound activity and IC50. As an exemplary for assessment of the SARS-COV2 Mpro, the C-His6-t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetReplicase polyprotein 1a(SARS-CoV)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM509782(US11124497, Compound 127 | US11124497, Compound 13...)
Affinity DataIC50: <2.00E+3nMAssay Description:Compounds are assayed using standard methods to assess compound activity and IC50. As an exemplary for assessment of the SARS-COV2 Mpro, the C-His6-t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


Displayed 1 to 50 (of 459 total ) | Next | Last >>
Jump to: