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TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50609061(CHEMBL5269567)
Affinity DataEC50:  0.0900nMAssay Description:Agonist activity at FXR in human HeLa cells by Dual-Glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM465458(US10793568, Compound I-110)
Affinity DataEC50:  0.100nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50639314(CHEMBL5559957)
Affinity DataEC50:  0.100nMAssay Description:Agonist activity at GST-tagged human FXR LBD expressed in HEK293T cotransfected with FXRE-luciferase reporter plasmid by luciferase reporter gene ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50639319(CHEMBL5559067)
Affinity DataEC50:  0.100nMAssay Description:Agonist activity at GST-tagged human FXR LBD expressed in HEK293T cotransfected with FXRE-luciferase reporter plasmid by luciferase reporter gene ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM465567(US10793568, Compound I-217)
Affinity DataEC50:  0.126nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM465447(US10793568, Compound I-101)
Affinity DataEC50:  0.158nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM465515(US10793568, Compound I-164)
Affinity DataEC50:  0.200nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM465399(US10793568, Compound I-18)
Affinity DataEC50:  0.200nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM465473(US10793568, Compound I-124)
Affinity DataEC50:  0.200nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50250860(CHEMBL4062567)
Affinity DataEC50:  0.200nMAssay Description:Agonist activity at recombinant human GST-tagged FXR ligand binding domain (193 to 472 residues) expressed in baculovirus infected insect cells asses...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM465464(US10793568, Compound I-115)
Affinity DataEC50:  0.251nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM465576(US10793568, Compound I-226)
Affinity DataEC50:  0.251nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM465471(US10793568, Compound I-122)
Affinity DataEC50:  0.251nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50250860(CHEMBL4062567)
Affinity DataEC50:  0.260nMAssay Description:Agonist activity at recombinant human GST-tagged FXR ligand binding domain (193 to 472 residues) expressed in baculovirus infected insect cells asses...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50250868(CHEMBL4083548)
Affinity DataEC50:  0.270nMAssay Description:Agonist activity at recombinant human GST-tagged FXR ligand binding domain (193 to 472 residues) expressed in baculovirus infected insect cells asses...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50609062(CHEMBL5271104)
Affinity DataEC50:  0.300nMAssay Description:Agonist activity at FXR in human HeLa cells by Dual-Glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50258109(CHEMBL4077016)
Affinity DataEC50:  0.300nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM465575(US10793568, Compound I-225)
Affinity DataEC50:  0.316nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM465460(US10793568, Compound I-112)
Affinity DataEC50:  0.398nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM465457(US10793568, Compound I-109)
Affinity DataEC50:  0.398nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM465453(US10793568, Compound I-105)
Affinity DataEC50:  0.398nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM465521(US10793568, Compound I-170)
Affinity DataEC50:  0.398nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM465487(US10793568, Compound I-135)
Affinity DataEC50:  0.398nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM465452(US10793568, Compound I-104)
Affinity DataEC50:  0.398nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM465566(US10793568, Compound I-216)
Affinity DataEC50:  0.398nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM465563(US10793568, Compound I-213)
Affinity DataEC50:  0.398nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50553984(CHEMBL4751757)
Affinity DataEC50:  0.400nMAssay Description:Agonist activity at human FXR expressed in HEK293 cells measured after 18 hrs by steady-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50241176(CHEMBL4074393)
Affinity DataEC50:  0.400nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50250870(CHEMBL4076774)
Affinity DataEC50:  0.420nMAssay Description:Agonist activity at recombinant human GST-tagged FXR ligand binding domain (193 to 472 residues) expressed in baculovirus infected insect cells asses...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50250869(CHEMBL4061776)
Affinity DataEC50:  0.460nMAssay Description:Agonist activity at recombinant human GST-tagged FXR ligand binding domain (193 to 472 residues) expressed in baculovirus infected insect cells asses...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50250867(CHEMBL4103787)
Affinity DataEC50:  0.490nMAssay Description:Agonist activity at recombinant human GST-tagged FXR ligand binding domain (193 to 472 residues) expressed in baculovirus infected insect cells asses...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50527040(LJN-452 | LJN452 | NVP-LJN452-NXA | Tropifexor)
Affinity DataEC50:  0.5nMAssay Description:Agonist activity at GST-tagged human FXR-LBD (193 to 472 residues) using biotinylated SRC-1 peptide as substrate incubated for 1 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50553985(CHEMBL4781153)
Affinity DataEC50:  0.5nMAssay Description:Agonist activity at human FXR expressed in HEK293 cells measured after 18 hrs by steady-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM465459(US10793568, Compound I-111)
Affinity DataEC50:  0.501nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM465477(US10793568, Compound I-127)
Affinity DataEC50:  0.501nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50544020(CHEMBL4638213)
Affinity DataEC50:  0.520nMAssay Description:Agonist activity at human FXR expressed in human HuH7 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50250869(CHEMBL4061776)
Affinity DataEC50:  0.540nMAssay Description:Agonist activity at recombinant human GST-tagged FXR ligand binding domain (193 to 472 residues) expressed in baculovirus infected insect cells asses...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50250866(CHEMBL4084716)
Affinity DataEC50:  0.540nMAssay Description:Agonist activity at recombinant human GST-tagged FXR ligand binding domain (193 to 472 residues) expressed in baculovirus infected insect cells asses...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50250870(CHEMBL4076774)
Affinity DataEC50:  0.570nMAssay Description:Agonist activity at recombinant human GST-tagged FXR ligand binding domain (193 to 472 residues) expressed in baculovirus infected insect cells asses...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM465562(US10793568, Compound I-212)
Affinity DataEC50:  0.631nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM465636(US10793568, Compound I-287)
Affinity DataEC50:  0.631nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM465524(US10793568, Compound I-173)
Affinity DataEC50:  0.631nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM465538(US10793568, Compound I-187)
Affinity DataEC50:  0.631nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM465504(US10793568, Compound I-153)
Affinity DataEC50:  0.631nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50250866(CHEMBL4084716)
Affinity DataEC50:  0.690nMAssay Description:Agonist activity at human FXR expressed in HEK293T cells assessed as BSEP promoter driven cellular transcriptional activity after 24 hrs by luciferas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50527040(LJN-452 | LJN452 | NVP-LJN452-NXA | Tropifexor)
Affinity DataEC50:  0.700nMAssay Description:Agonist activity at FXR transfected in human HEK293T cells o-expressing pGL3/hBSEP/luc incubated for 24 hrs by Steady-Glo reagent based luciferase re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50553986(CHEMBL4794704)
Affinity DataEC50:  0.700nMAssay Description:Agonist activity at human FXR expressed in HEK293 cells measured after 18 hrs by steady-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM465601(US10793568, Compound I-251)
Affinity DataEC50:  0.794nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM465456(US10793568, Compound I-108)
Affinity DataEC50:  0.794nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

TargetBile acid receptor(Human)
University of Health Sciences and Pharmacy

Curated by ChEMBL
LigandPNGBDBM465491(US10793568, Compound I-140)
Affinity DataEC50:  0.794nMAssay Description:The affinity of FXR ligands for the ligand binding domain of FXR was determined using a commercially available human FXR ligand binding assay (Lantha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

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