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Found 3224 of ic50 for UniProtKB: Q96DB2
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50366693(CHEMBL1793812)
Affinity DataIC50: <0.100nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) derived from partially purified extracts of human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50101331(CHEMBL3329621)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of HDAC11 (unknown origin) incubated for 3 hrs in presence of BSA and DTT by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1/11/4/6/8(Homo sapiens (Human))
Orchid Chemicals & Pharmaceuticals

LigandPNGBDBM65470(Quinolone-based HDAC inhibitor 4i)
Affinity DataIC50:  0.100nMAssay Description:Histone Deacetylase (HDAC) Inhibition Assay using Boc-Lys(Ac)-AMC Substrate: Inhibition of HDAC has been implicated to modulate transcription and to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50366696(CHEMBL1793811)
Affinity DataIC50:  0.200nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) derived from partially purified extracts of human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50101330(CHEMBL3329622)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of HDAC11 (unknown origin) incubated for 3 hrs in presence of BSA and DTT by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50218940(CHEMBL1793991)
Affinity DataIC50:  0.200nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) enzyme derived from partially purified extracts of human HeLa cells using [3H]11 as radioligan...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50366738(CHEMBL1793985)
Affinity DataIC50:  0.200nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) enzyme derived from partially purified extracts of human HeLa cells using [3H]11 as radioligan...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50366712(CHEMBL1793822)
Affinity DataIC50:  0.300nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) derived from partially purified extracts of human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50588303(CHEMBL5170036)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of HDAC (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50354086(FK-228 | Istodax | ROMIDEPSIN)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of HDAC11 (unknown origin) incubated for 3 hrs in presence of BSA and DTT by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50588302(CHEMBL5199116)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of HDAC (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50048864(CHEMBL3310505)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of HDAC11 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50105327(JNJ-26481585 | Quisinostat)
Affinity DataIC50:  0.370nMAssay Description:Inhibition of HDAC11 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50105327(JNJ-26481585 | Quisinostat)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human HDAC11 expressed in baculovirus infected sf9 cells using (Boc-Lys(trifluoroacetyl)-AMC) as substrate by fluorescence-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50366713(CHEMBL1793816)
Affinity DataIC50:  0.400nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) derived from partially purified extracts of human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Affinity DataIC50:  0.830nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract using Ac-Leu-Gly-Lys (Ac)-AMC as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50531374(CHEMBL4467135)
Affinity DataIC50:  1nMAssay Description:Inhibition of HDAC (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141381(CHEMBL3758184)
Affinity DataIC50:  1nMAssay Description:Inhibition of HDAC in human HeLa cells nuclear extract using Fluor de lys as substrate after 15 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50238632((6S,9S,12S,14aR)-6-((S)-sec-Butyl)-9-(1-methoxy-1H...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) enzyme derived from partially purified extracts of human HeLa cells using [3H]11 as radioligan...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50366706(CHEMBL1793810)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) derived from partially purified extracts of human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50218877(CHEMBL1793823)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) derived from partially purified extracts of human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50218879(CHEMBL1793947)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) derived from partially purified extracts of human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50273535(CHEMBL4130288 | US11535607, Example 18-1)
Affinity DataIC50:  1nMAssay Description:Inhibition of full length recombinant human HDAC11 expressed in baculoviral expression system using FAM-RHKK as substrate by electrophoretic mobility...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50027494(CHEMBL3356916)
Affinity DataIC50:  1nMAssay Description:Inhibition of HDAC11 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50048864(CHEMBL3310505)
Affinity DataIC50:  1nMAssay Description:Inhibition of partially purified HDAC isolated from human M8 cells enzyme fraction pre-incubated for 5 mins before [3H]acetylated histone addition an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50218931(CHEMBL1793992)
Affinity DataIC50:  1.30nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) enzyme derived from partially purified extracts of human HeLa cells using [3H]11 as radioligan...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50079798(CHEMBL99661)
Affinity DataIC50:  1.40nMAssay Description:Concentration required to inhibit Histone Deacetylase (HDAC) from K562 erythroleukemia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005711(CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract using BML-KI104 Fluor de Lys as substrate by fluorescence-based assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1/11/4/6/8(Homo sapiens (Human))
Orchid Chemicals & Pharmaceuticals

LigandPNGBDBM65471(Quinolone-based HDAC inhibitor 4j)
Affinity DataIC50:  1.5nMAssay Description:Histone Deacetylase (HDAC) Inhibition Assay using Boc-Lys(Ac)-AMC Substrate: Inhibition of HDAC has been implicated to modulate transcription and to ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of HDAC11 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50478829(6-(6-Methoxynaphthalyl)Triazolylhexahydroxamic Aci...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of human HDAC in HeLa cells by flour de lys assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50478811(6-(3-Biphenyl)Triazolylhexahydroxamic Acid | CHEMB...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human HDAC in HeLa cells by flour de lys assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50460430(CHEMBL4228304)
Affinity DataIC50:  2nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract using Boc-Lys (acetyl)-AMC as substrate preincubated for 5 mins followed by substrate addition ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50273525(CHEMBL4128972 | US11535607, Example 18-2)
Affinity DataIC50:  2nMAssay Description:Inhibition of full length recombinant human HDAC11 expressed in baculoviral expression system using FAM-RHKK as substrate by electrophoretic mobility...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50273553(CHEMBL4127020 | US10508088, ID HDTK028 | US1153560...)
Affinity DataIC50:  2nMAssay Description:Inhibition of full length recombinant human HDAC11 expressed in baculoviral expression system using FAM-RHKK as substrate by electrophoretic mobility...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50273522(CHEMBL4127743 | US11535607, Example 12-1)
Affinity DataIC50:  2nMAssay Description:Inhibition of full length recombinant human HDAC11 expressed in baculoviral expression system using FAM-RHKK as substrate by electrophoretic mobility...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50082325(CHEMBL99392)
Affinity DataIC50:  2nMAssay Description:Concentration required to inhibit Histone Deacetylase (HDAC) from K562 erythroleukemia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50460420(CHEMBL4228565)
Affinity DataIC50:  2nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract using Boc-Lys (acetyl)-AMC as substrate preincubated for 5 mins followed by substrate addition ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50366745(CHEMBL1793989)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) enzyme derived from partially purified extracts of human HeLa cells using [3H]11 as radioligan...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50218869(CHEMBL1793938)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) derived from partially purified extracts of human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50512074(CHEMBL4575813)
Affinity DataIC50:  2nMAssay Description:Inhibition of HDAC in human HeLa nuclear extract using Boc-Lys(acetyl)-AMC as substrate preincubated for 5 mins followed by substrate addition and me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50512068(CHEMBL4526274)
Affinity DataIC50:  2nMAssay Description:Inhibition of HDAC in human HeLa nuclear extract using Boc-Lys(acetyl)-AMC as substrate preincubated for 5 mins followed by substrate addition and me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50478814(6-(4-Anisolyl)Triazolylhexahydroxamic Acid | CHEMB...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human HDAC in HeLa cells by flour de lys assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of HDAC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50099379(CHEMBL95881)
Affinity DataIC50:  2.10nMAssay Description:Concentration required to inhibit Histone Deacetylase (HDAC) from K562 erythroleukemia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50478823(6-(2-Quinolyl)Triazolylhexahydroxamic Acid | CHEMB...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human HDAC in HeLa cells by flour de lys assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50304782(CHEMBL609583 | N-hydroxy-2-(4-(naphthalen-2-ylsulf...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human HDAC11More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50142838(CHEMBL3758697)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of HDAC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50142796(CHEMBL3759186)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extracts preincubated for 15 mins followed by addition of Fluor de Lys as substrate for 1 hr by fluorom...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50142796(CHEMBL3759186)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of HDAC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
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