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TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM35723(CHEMBL344159 | N-[4-(7-Chloro-5-hydroxy-2,3,4,5-te...)
Affinity DataIC50:  0.00700nMAssay Description:Antagonist activity at human AVPR2 by PathHunter beta-arrestin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM50146577(CHEMBL102311 | spirobenzoxazines analogues)
Affinity DataIC50:  0.200nMAssay Description:In vitro inhibitory concentration against [3H]-AVP binding to cloned human vasopressin receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM50065118(CHEMBL311931 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Affinity DataIC50:  0.5nMAssay Description:Displacement of [3H]-AVP from human V2 receptor expressed in murine fibroblast cell line (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM50307117(CHEMBL603708 | N-(4-(2,3,4,5-tetrahydro-1H-benzo[b...)
Affinity DataIC50:  0.570nMAssay Description:Antagonist activity at V2 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM50065123(CHEMBL420031 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Affinity DataIC50:  0.700nMAssay Description:Displacement of [3H]-AVP from human V2 receptor expressed in murine fibroblast cell line (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM50078646(CHEMBL49322 | N-[4-(4,10-Dihydro-1-thia-9-aza-benz...)
Affinity DataIC50:  0.700nMAssay Description:In vitro inhibition of [3H]-AVP binding to human V2 receptor from murine fibroblast cell line (LV2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM50094076(CHEMBL434654 | N-[4-(7-Chloro-2,3,4,5-tetrahydro-b...)
Affinity DataIC50:  0.950nMAssay Description:Concentration of the compound which inhibit [3H]-AVP binding to human Vasopressin V2 receptor coded HeLa cells by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM50065121(CHEMBL310416 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Affinity DataIC50:  1nMAssay Description:Displacement of [3H]-AVP from human V2 receptor expressed in murine fibroblast cell line (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM190302(US9180120, 6)
Affinity DataIC50:  1nMAssay Description:On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates an...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM50137945(Biphenyl-2-carboxylic acid [2-[4-(4-methyl-piperaz...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against human recombinant arginine vasopressin V2 receptor using [3H]-AVP as radioligand in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)
Affinity DataIC50:  1nMAssay Description:Inhibition of [3H]-AVP binding to human V2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)
Affinity DataIC50:  1.20nMAssay Description:Displacement of [3H]-AVP from human V2 receptor expressed in murine fibroblast cell line (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)
Affinity DataIC50:  1.20nMAssay Description:Displacement of [3H]AVP from human vasopressin V2 receptor expressed in mouse LV2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)
Affinity DataIC50:  1.20nMAssay Description:In vitro inhibition of [3H]-AVP binding to human V2 receptor from murine fibroblast cell line (LV2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)
Affinity DataIC50:  1.20nMAssay Description:Displacement of [3H]-AVP from human vasopressin V2-receptor expressed in murine fibroblast cell (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)
Affinity DataIC50:  1.20nMAssay Description:In vitro binding affinity to human V2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM50087670(Biphenyl-2-carboxylic acid {3-chloro-4-[3-(4-methy...)
Affinity DataIC50:  1.30nMAssay Description:Displacement of [3H]-AVP from human vasopressin V2-receptor expressed in murine fibroblast cell (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM192452(US9187466, 50 | US9687476, 50)
Affinity DataIC50:  1.40nMAssay Description:On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates an...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM192452(US9187466, 50 | US9687476, 50)
Affinity DataIC50:  1.40nMT: 2°CAssay Description:On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates an...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM50065124(CHEMBL68085 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a][...)
Affinity DataIC50:  1.5nMAssay Description:Displacement of [3H]-AVP from human V2 receptor expressed in murine fibroblast cell line (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM192451(US9187466, 49 | US9687476, 49)
Affinity DataIC50:  1.5nMT: 2°CAssay Description:On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates an...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM192451(US9187466, 49 | US9687476, 49)
Affinity DataIC50:  1.5nMAssay Description:On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates an...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM50087551(Biphenyl-2-carboxylic acid [3-chloro-4-(4,5-dihydr...)
Affinity DataIC50:  1.70nMAssay Description:In vitro binding affinity to human V2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM50065111(CHEMBL80029 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a][...)
Affinity DataIC50:  1.90nMAssay Description:Displacement of [3H]-AVP from human V2 receptor expressed in murine fibroblast cell line (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM50065112(CHEMBL81269 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a][...)
Affinity DataIC50:  1.90nMAssay Description:Displacement of [3H]-AVP from human V2 receptor expressed in murine fibroblast cell line (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM50065129(CHEMBL312036 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]-AVP from human V2 receptor expressed in murine fibroblast cell line (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM190348(US9180120, 52)
Affinity DataIC50:  2nMAssay Description:On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates an...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM190343(US9180120, 47)
Affinity DataIC50:  2nMAssay Description:On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates an...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM192449(US9187466, 32 | US9687476, 32)
Affinity DataIC50:  2nMAssay Description:On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates an...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM50087664(Biphenyl-2-carboxylic acid {3-chloro-4-[3-(4-dimet...)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]-AVP from human vasopressin V2-receptor expressed in murine fibroblast cell (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM192449(US9187466, 32 | US9687476, 32)
Affinity DataIC50:  2nMT: 2°CAssay Description:On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates an...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM50137948(Biphenyl-2-carboxylic acid [2-[3-(4-methyl-[1,4]di...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against human recombinant arginine vasopressin V2 receptor using [3H]-AVP as radioligand in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM50065125(CHEMBL311230 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]-AVP from human V2 receptor expressed in murine fibroblast cell line (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM50065128(CHEMBL81133 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a][...)
Affinity DataIC50:  2.10nMAssay Description:Displacement of [3H]-AVP from human V2 receptor expressed in murine fibroblast cell line (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM50087675(Biphenyl-2-carboxylic acid [4-(3-[1,4']bipiperidin...)
Affinity DataIC50:  2.10nMAssay Description:Displacement of [3H]-AVP from human vasopressin V2-receptor expressed in murine fibroblast cell (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM466527(2-{[5-Acetyl-1-(3-chlorophenyl)-1H-1,2,4-triazol-3...)
Affinity DataIC50:  2.30nMAssay Description:The identification of agonists and antagonists of the V1a and V2 vasopressin receptors from humans, rats and dogs as well as the quantification of th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM50087674(Biphenyl-2-carboxylic acid [3-chloro-4-(3-{[(2-dim...)
Affinity DataIC50:  2.60nMAssay Description:Displacement of [3H]-AVP from human vasopressin V2-receptor expressed in murine fibroblast cell (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM50087541(Biphenyl-2-carboxylic acid [4-(5H,11H-benzo[e]pyrr...)
Affinity DataIC50:  2.70nMAssay Description:In vitro binding affinity to human V2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM466531(5-(4-Chlorophenyl)-2-({1-(3-chlorophenyl)-5-[(1S,R...)
Affinity DataIC50:  2.80nMAssay Description:The identification of agonists and antagonists of the V1a and V2 vasopressin receptors from humans, rats and dogs as well as the quantification of th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM190338(US9180120, 42)
Affinity DataIC50:  3nMAssay Description:On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtitre plates an...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM35718(benzazepine derivative, 20)
Affinity DataIC50:  3nMpH: 7.4 T: 2°CAssay Description:After reaching confluence in 12-well or 24-well dishes, the cells were washed twice with ice-cold PBS and incubated for 2 hr with [3H]-AVP at 4 deg C...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM35723(CHEMBL344159 | N-[4-(7-Chloro-5-hydroxy-2,3,4,5-te...)
Affinity DataIC50:  3nMpH: 7.4 T: 2°CAssay Description:After reaching confluence in 12-well or 24-well dishes, the cells were washed twice with ice-cold PBS and incubated for 2 hr with [3H]-AVP at 4 deg C...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM50065110(CHEMBL418890 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Affinity DataIC50:  3.20nMAssay Description:Displacement of [3H]-AVP from human V2 receptor expressed in murine fibroblast cell line (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM50065110(CHEMBL418890 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Affinity DataIC50:  3.20nMAssay Description:In vitro binding affinity to human V2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM192468(US10800746, Example WO 2011/104322 110 | US9187466...)
Affinity DataIC50:  3.30nMT: 2°CAssay Description:On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM192468(US10800746, Example WO 2011/104322 110 | US9187466...)
Affinity DataIC50:  3.30nMAssay Description:On the day before the assay, the cells are plated out in culture medium (DMEM, 10% FCS, 2 mM glutamine, 10 mM HEPES) in 384-well microtiter plates an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM50087542(CHEMBL350089 | N-[3-Chloro-4-(5,6,7,8-tetrahydro-t...)
Affinity DataIC50:  3.40nMAssay Description:In vitro binding affinity to human V2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM50119815(3-chloro-4-[16-methyl-(12S)-2,10-diazatetracyclo[1...)
Affinity DataIC50:  4nMAssay Description:Inhibition of [3H]-Arg-vasopressin binding to recombinant human vasopressin V2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM50087667(10-{4-[(Biphenyl-2-carbonyl)-amino]-2-chloro-benzo...)
Affinity DataIC50:  4nMAssay Description:Displacement of [3H]-AVP from human vasopressin V2-receptor expressed in murine fibroblast cell (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM50065122(CHEMBL306970 | N-[4-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Affinity DataIC50:  4nMAssay Description:Displacement of [3H]-AVP from human V2 receptor expressed in murine fibroblast cell line (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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