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TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM701209(4-[2-(N-[(1S)-3,3-difluorocyclohexyl]anilino)- 2-o...)
Affinity DataKi:  0.114nMAssay Description:Receptor binding affinities (Ki) were determined from a competitive radioligand binding assay with human recombinant ([125I]-Tyr4)-Angiotensin-II (22...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM50030815(CHEMBL404594)
Affinity DataKi:  0.140nMAssay Description:Binding affinity to AT2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM50030815(CHEMBL404594)
Affinity DataKi:  0.140nMAssay Description:Binding affinity to type-2 angiotensin-2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2017
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM50370684(CHEMBL1791349)
Affinity DataKi:  0.180nMpH: 7.4Assay Description:Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM50236697(L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-iso...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity to type-2 angiotensin-2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2017
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM50370575(CHEMBL1791308)
Affinity DataKi:  0.300nMAssay Description:Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM50370575(CHEMBL1791308)
Affinity DataKi:  0.300nMAssay Description:Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM50622931(CHEMBL5409738 | US12122750, Example 44)
Affinity DataKi:  0.311nMAssay Description:Receptor binding affinities (Ki) were determined from a competitive radioligand binding assay with human recombinant ([125I]-Tyr4)-Angiotensin-II (22...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM50622931(CHEMBL5409738 | US12122750, Example 44)
Affinity DataKi:  0.311nMAssay Description:Displacement of ([125I]-Tyr4)-Angiotensin-II from recombinant human AT2R by gamma scintillation counter assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM50622929(CHEMBL5416925 | US12122750, Example 11)
Affinity DataKi:  0.336nMAssay Description:Displacement of ([125I]-Tyr4)-Angiotensin-II from recombinant human AT2R by gamma scintillation counter assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM50622929(CHEMBL5416925 | US12122750, Example 11)
Affinity DataKi:  0.336nMAssay Description:Receptor binding affinities (Ki) were determined from a competitive radioligand binding assay with human recombinant ([125I]-Tyr4)-Angiotensin-II (22...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM50622932(CHEMBL5400661 | US12122750, Example 53)
Affinity DataKi:  0.342nMAssay Description:Receptor binding affinities (Ki) were determined from a competitive radioligand binding assay with human recombinant ([125I]-Tyr4)-Angiotensin-II (22...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM50622932(CHEMBL5400661 | US12122750, Example 53)
Affinity DataKi:  0.342nMAssay Description:Displacement of ([125I]-Tyr4)-Angiotensin-II from recombinant human AT2R by gamma scintillation counter assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM50622930(CHEMBL5408779 | US12122750, Example 32)
Affinity DataKi:  0.345nMAssay Description:Displacement of ([125I]-Tyr4)-Angiotensin-II from recombinant human AT2R by gamma scintillation counter assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM50622930(CHEMBL5408779 | US12122750, Example 32)
Affinity DataKi:  0.345nMAssay Description:Receptor binding affinities (Ki) were determined from a competitive radioligand binding assay with human recombinant ([125I]-Tyr4)-Angiotensin-II (22...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM50622927(CHEMBL5430412 | US12122750, Example 2)
Affinity DataKi:  0.352nMAssay Description:Displacement of ([125I]-Tyr4)-Angiotensin-II from recombinant human AT2R by gamma scintillation counter assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM50622927(CHEMBL5430412 | US12122750, Example 2)
Affinity DataKi:  0.352nMAssay Description:Receptor binding affinities (Ki) were determined from a competitive radioligand binding assay with human recombinant ([125I]-Tyr4)-Angiotensin-II (22...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM50009338(Sar-Arg-Val-Tyr-Val-His-Pro-Ala | (S)-2-((S)-1-((S...)
Affinity DataKi:  0.380nMAssay Description:Binding affinity to AT2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM50009338(Sar-Arg-Val-Tyr-Val-His-Pro-Ala | (S)-2-((S)-1-((S...)
Affinity DataKi:  0.380nMAssay Description:Binding affinity to type-2 angiotensin-2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2017
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM50622928(CHEMBL5430333 | US12122750, Example 7)
Affinity DataKi:  0.382nMAssay Description:Displacement of ([125I]-Tyr4)-Angiotensin-II from recombinant human AT2R by gamma scintillation counter assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM50622928(CHEMBL5430333 | US12122750, Example 7)
Affinity DataKi:  0.382nMAssay Description:Receptor binding affinities (Ki) were determined from a competitive radioligand binding assay with human recombinant ([125I]-Tyr4)-Angiotensin-II (22...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM701241(4-[2-(N-(3,3-difluorocyclohexyl)anilino)-2- oxo-et...)
Affinity DataKi:  0.383nMAssay Description:Receptor binding affinities (Ki) were determined from a competitive radioligand binding assay with human recombinant ([125I]-Tyr4)-Angiotensin-II (22...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM50156173(butyl 3-(4-((1H-imidazol-1-yl)methyl)phenyl)-5-iso...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to AT2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM50156173(butyl 3-(4-((1H-imidazol-1-yl)methyl)phenyl)-5-iso...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to AT2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM50156173(butyl 3-(4-((1H-imidazol-1-yl)methyl)phenyl)-5-iso...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to AT2R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM50156173(butyl 3-(4-((1H-imidazol-1-yl)methyl)phenyl)-5-iso...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM50156173(butyl 3-(4-((1H-imidazol-1-yl)methyl)phenyl)-5-iso...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to type-2 angiotensin-2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2017
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM701184(4-[2-(N-cyclohexyl-3-fluoro-anilino)-2-oxo- ethyl]...)
Affinity DataKi:  0.400nMAssay Description:Receptor binding affinities (Ki) were determined from a competitive radioligand binding assay with human recombinant ([125I]-Tyr4)-Angiotensin-II (22...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM50156173(butyl 3-(4-((1H-imidazol-1-yl)methyl)phenyl)-5-iso...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to AT2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM701213(4-[2-(2-fluoro-N-(2-fluorophenyl)anilino)-2- oxo-e...)
Affinity DataKi:  0.409nMAssay Description:Receptor binding affinities (Ki) were determined from a competitive radioligand binding assay with human recombinant ([125I]-Tyr4)-Angiotensin-II (22...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM701176(1-[methyl(phenyl)carbamoyl]-4-[2-oxo-2-(N- phenyla...)
Affinity DataKi:  0.428nMAssay Description:Receptor binding affinities (Ki) were determined from a competitive radioligand binding assay with human recombinant ([125I]-Tyr4)-Angiotensin-II (22...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM701218(4-[2-(N-(3,3-difluorocyclohexyl)anilino)-2- oxo-et...)
Affinity DataKi:  0.471nMAssay Description:Receptor binding affinities (Ki) were determined from a competitive radioligand binding assay with human recombinant ([125I]-Tyr4)-Angiotensin-II (22...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM50199311(N-butyloxycarbonyl-2-(4-imidazol-1-ylmethylphenyl)...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM50156167(butyl (5-isobutylthien-2-yl)sulfonylcarbamate deri...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM701169(4-[2-(N-cyclohexylanilino)-2-oxo-ethyl]-1-[(2- flu...)
Affinity DataKi:  0.521nMAssay Description:Receptor binding affinities (Ki) were determined from a competitive radioligand binding assay with human recombinant ([125I]-Tyr4)-Angiotensin-II (22...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM701179(1-[(4-fluorophenyl)-methyl-carbamoyl]-4-[2- (N-(3-...)
Affinity DataKi:  0.573nMAssay Description:Receptor binding affinities (Ki) were determined from a competitive radioligand binding assay with human recombinant ([125I]-Tyr4)-Angiotensin-II (22...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM701219(4-[2-(N-(3,3-difluorocyclohexyl)-2-fluoro- anilino...)
Affinity DataKi:  0.580nMAssay Description:Receptor binding affinities (Ki) were determined from a competitive radioligand binding assay with human recombinant ([125I]-Tyr4)-Angiotensin-II (22...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM50199326(N-butyloxycarbonyl-2-(4-imidazol-1-ylmethylphenyl)...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM701233(4-[2-(N-(3,3-difluorocyclohexyl)anilino)-2- oxo-et...)
Affinity DataKi:  0.619nMAssay Description:Receptor binding affinities (Ki) were determined from a competitive radioligand binding assay with human recombinant ([125I]-Tyr4)-Angiotensin-II (22...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM50139783(Angiotensin II analogue | CHEMBL404996)
Affinity DataKi:  0.620nMAssay Description:Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM50199326(N-butyloxycarbonyl-2-(4-imidazol-1-ylmethylphenyl)...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity to angiotensin II receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM50370686(CHEMBL1791350)
Affinity DataKi:  0.700nMpH: 7.4Assay Description:Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM50199326(N-butyloxycarbonyl-2-(4-imidazol-1-ylmethylphenyl)...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity to type-2 angiotensin-2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2017
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM50370375(CHEMBL268815)
Affinity DataKi:  0.700nMAssay Description:Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM701187(4-[2-(N-(4-fluorophenyl)anilino)-2-oxo-ethyl]- 1-[...)
Affinity DataKi:  0.716nMAssay Description:Receptor binding affinities (Ki) were determined from a competitive radioligand binding assay with human recombinant ([125I]-Tyr4)-Angiotensin-II (22...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM701181(4-[2-(N-(3-fluorophenyl)anilino)-2-oxo-ethyl]- 1-[...)
Affinity DataKi:  0.774nMAssay Description:Receptor binding affinities (Ki) were determined from a competitive radioligand binding assay with human recombinant ([125I]-Tyr4)-Angiotensin-II (22...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM50168428((3S)-3-amino-3-{[(1S)-1-{[(1S)-1-{[(2S)-4-({[(2S)-...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM701180(1-[(4-fluorophenyl)-methyl-carbamoyl]-4-[2- [N-(m-...)
Affinity DataKi:  0.823nMAssay Description:Receptor binding affinities (Ki) were determined from a competitive radioligand binding assay with human recombinant ([125I]-Tyr4)-Angiotensin-II (22...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM50236697(L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-iso...)
Affinity DataKi:  0.898nMAssay Description: 120 μL membrane (5 mg protein/well) was incubated with 15 μL of [125I]-CGP42112A and 15 μL of compound at RT for 1.5 hrs. The binding...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetType-2 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM410295(US10370388, Compound Angiotensin)
Affinity DataKi:  0.898nMAssay Description: 120 μL membrane (5 mg protein/well) was incubated with 15 μL of [125I]-CGP42112A and 15 μL of compound at RT for 1.5 hrs. The binding...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
US Patent

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