Compile Data Set for Download or QSAR
maximum 50k data
Found 204 of ec50 for UniProtKB: P32297
TargetNeuronal acetylcholine receptor subunit alpha-3(Homo sapiens (Human))
Burnham Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50201064((1R,6S)-2-bromo-5-(3,8-diaza-bicyclo[4.2.0]oct-3-y...)
Affinity DataEC50:  4.37nMAssay Description:Agonist activity against human alpha3beta4 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Homo sapiens (Human))
Burnham Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataEC50:  7nMAssay Description:Functional activation of human sympathetic ganglionic type nAChRs in IMR-32 cells containing alpha-3 subtypeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataEC50:  7nMAssay Description:Compound was evaluated for functional potency and efficacy at human Nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Homo sapiens (Human))
Burnham Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50201055((1R,6S)-3-(6-chloro-5-methyl-pyridin-3-yl)-3,8-dia...)
Affinity DataEC50:  7.24nMAssay Description:Agonist activity against human alpha3beta4 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Homo sapiens (Human))
Burnham Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50201072((1R,6S)-3-(6-bromo-5-methoxy-pyridin-3-yl)-3,8-dia...)
Affinity DataEC50:  7.94nMAssay Description:Agonist activity against human alpha3beta4 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Homo sapiens (Human))
Burnham Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50201048((1R,6S)-3-(5,6-dibromo-pyridin-3-yl)-3,8-diaza-bic...)
Affinity DataEC50:  8.13nMAssay Description:Agonist activity against human alpha3beta4 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Homo sapiens (Human))
Burnham Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50201061((1R,6S)-3-(5,6-dichloro-pyridin-3-yl)-3,8-diaza-bi...)
Affinity DataEC50:  10nMAssay Description:Agonist activity against human alpha3beta4 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50240856(7-Methyl-2-pyridazin-4-yl-7-aza-bicyclo[2.2.1]hept...)
Affinity DataEC50:  13nMAssay Description:Effective concentration against Nicotinic acetylcholine receptor alpha3-beta2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataEC50:  19nMAssay Description:Binding affinity against nicotinic acetylcholine receptor alpha3-beta4 using [3H]epibatidine as radioligand expressed in HEK293 cells or tsA cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Homo sapiens (Human))
Burnham Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50411219(CHEMBL479614)
Affinity DataEC50:  25.1nMAssay Description:Agonist activity against human alpha3beta4 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Homo sapiens (Human))
Burnham Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataEC50:  27nMAssay Description:Agonist activity at human recombinant alpha3beta4 nAChR expressed in human IMR32 cells assessed as calcium dynamics by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataEC50:  28nMAssay Description:Agonist activity at alpha-3-beta-4 nAChR in KXalpha-3-beta-4R2 cells by rubidium efflux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Homo sapiens (Human))
Burnham Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50201062((1R,6S)-3-(6-chloro-pyridin-3-yl)-3,8-diaza-bicycl...)
Affinity DataEC50:  28.8nMAssay Description:Agonist activity against human alpha3beta4 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Homo sapiens (Human))
Burnham Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50201069((1R,6S)-3-(pyridin-3-yl)-3,8-diaza-bicyclo[4.2.0]o...)
Affinity DataEC50:  47.9nMAssay Description:Agonist activity against human alpha3beta4 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50498034(CHEMBL3329543)
Affinity DataEC50:  51nMAssay Description:Agonist activity at human alpha6/alpha3beta2beta3 nAChR transfected in CHO cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50498033(CHEMBL3329540)
Affinity DataEC50:  53nMAssay Description:Agonist activity at human alpha6/alpha3beta2beta3 nAChR transfected in CHO cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50498045(CHEMBL3329537)
Affinity DataEC50:  62nMAssay Description:Agonist activity at human alpha6/alpha3beta2beta3 nAChR transfected in CHO cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Homo sapiens (Human))
Burnham Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50411210(CHEMBL481977)
Affinity DataEC50:  70.8nMAssay Description:Agonist activity against human alpha3beta4 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Homo sapiens (Human))
Burnham Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50201059((1R,6S)-3-(5-bromo-pyridin-3-yl)-3,8-diaza-bicyclo...)
Affinity DataEC50:  75.9nMAssay Description:Agonist activity against human alpha3beta4 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50498051(CHEMBL3329528)
Affinity DataEC50:  80nMAssay Description:Agonist activity at human alpha6/alpha3beta2beta3 nAChR transfected in CHO cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50498046(CHEMBL3329538)
Affinity DataEC50:  88nMAssay Description:Agonist activity at human alpha6/alpha3beta2beta3 nAChR transfected in CHO cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50498052(CHEMBL3329546)
Affinity DataEC50:  100nMAssay Description:Agonist activity at human alpha6/alpha3beta2beta3 nAChR transfected in CHO cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Homo sapiens (Human))
Burnham Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50411228(CHEMBL448457)
Affinity DataEC50:  110nMAssay Description:Agonist activity against human alpha3beta4 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Homo sapiens (Human))
Burnham Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50411226(CHEMBL506353)
Affinity DataEC50:  110nMAssay Description:Agonist activity against human alpha3beta4 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Homo sapiens (Human))
Burnham Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50201065((1R,6S)-3-(5-ethoxy-pyridin-3-yl)-3,8-diaza-bicycl...)
Affinity DataEC50:  123nMAssay Description:Agonist activity against human alpha3beta4 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Homo sapiens (Human))
Burnham Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50411225(CHEMBL451632)
Affinity DataEC50:  158nMAssay Description:Agonist activity against human alpha3beta4 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50498035(CHEMBL3329530)
Affinity DataEC50:  180nMAssay Description:Agonist activity at human alpha6/alpha3beta2beta3 nAChR transfected in CHO cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Homo sapiens (Human))
Burnham Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50201073((1R,6S)-3-(5-methoxy-pyridin-3-yl)-3,8-diaza-bicyc...)
Affinity DataEC50:  182nMAssay Description:Agonist activity against human alpha3beta4 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Homo sapiens (Human))
Burnham Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50062641(5-((R)-1-Azetidin-2-ylmethoxy)-2-chloro-pyridine |...)
Affinity DataEC50:  190nMAssay Description:Agonist activity at human recombinant alpha3beta4 nAChR expressed in human IMR32 cells assessed as calcium dynamics by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Homo sapiens (Human))
Burnham Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50062641(5-((R)-1-Azetidin-2-ylmethoxy)-2-chloro-pyridine |...)
Affinity DataEC50:  200nMAssay Description:Bindind affinity value obtained by measuring the displacement of radioligand [3H]-(-)-cytisine from whole rat brain Nicotinic acetylcholine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Homo sapiens (Human))
Burnham Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50062641(5-((R)-1-Azetidin-2-ylmethoxy)-2-chloro-pyridine |...)
Affinity DataEC50:  200nMAssay Description:Functional activation of human sympathetic ganglionic type nAChRs in IMR-32 cells containing alpha-3 subtypeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Homo sapiens (Human))
Burnham Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50411212(CHEMBL481002)
Affinity DataEC50:  204nMAssay Description:Agonist activity against human alpha3beta4 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Homo sapiens (Human))
Burnham Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50411209(CHEMBL448697)
Affinity DataEC50:  240nMAssay Description:Agonist activity against human alpha3beta4 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Homo sapiens (Human))
Burnham Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50411218(CHEMBL479613)
Affinity DataEC50:  257nMAssay Description:Agonist activity against human alpha3beta4 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Homo sapiens (Human))
Burnham Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50411213(CHEMBL468065)
Affinity DataEC50:  295nMAssay Description:Agonist activity against human alpha3beta4 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50498041(CHEMBL3329531)
Affinity DataEC50:  300nMAssay Description:Agonist activity at human alpha6/alpha3beta2beta3 nAChR transfected in CHO cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Homo sapiens (Human))
Burnham Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50411229(CHEMBL450667)
Affinity DataEC50:  339nMAssay Description:Agonist activity against human alpha3beta4 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50498040(CHEMBL3329533)
Affinity DataEC50:  370nMAssay Description:Agonist activity at human alpha6/alpha3beta2beta3 nAChR transfected in CHO cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Homo sapiens (Human))
Burnham Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50201056((1R,6S)-3-(6-nitro-pyridin-3-yl)-3,8-diaza-bicyclo...)
Affinity DataEC50:  389nMAssay Description:Agonist activity against human alpha3beta4 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50530216(CHEMBL4582201)
Affinity DataEC50:  430nMAssay Description:Agonist activity at human alpha3beta2 nAChR expressed in Xenopus laevis oocytes after 4 to 5 days at -60 mV holding potential by patch clamp assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50530216(CHEMBL4582201)
Affinity DataEC50:  430nMAssay Description:Agonist activity at human alpha3beta2 nAChR expressed in Xenopus laevis oocytes after 4 to 5 days at -60 mV holding potential by patch clamp assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Homo sapiens (Human))
Burnham Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50201058((1S,6R)-5-(3,8-diaza-bicyclo[4.2.0]oct-3-yl)-nicot...)
Affinity DataEC50:  490nMAssay Description:Agonist activity against human alpha3beta4 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Homo sapiens (Human))
Burnham Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50062642(2-Chloro-5-((R)-1-pyrrolidin-2-ylmethoxy)-pyridine...)
Affinity DataEC50:  500nMAssay Description:Functional activation of human sympathetic ganglionic type nAChRs in IMR-32 cells containing alpha-3 subtypeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50498053(CHEMBL3329545)
Affinity DataEC50:  540nMAssay Description:Agonist activity at human alpha6/alpha3beta2beta3 nAChR transfected in CHO cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50498047(CHEMBL3329539)
Affinity DataEC50:  620nMAssay Description:Agonist activity at human alpha6/alpha3beta2beta3 nAChR transfected in CHO cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Homo sapiens (Human))
Burnham Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50049750((S)-3-(azetidin-2-ylmethoxy)pyridine | 3-((S)-1-Az...)
Affinity DataEC50:  700nMAssay Description:Functional activation of human sympathetic ganglionic type nAChRs in IMR-32 cells containing alpha-3 subtypeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50049750((S)-3-(azetidin-2-ylmethoxy)pyridine | 3-((S)-1-Az...)
Affinity DataEC50:  700nMAssay Description:Compound was evaluated for functional potency and efficacy at rat Nicotinic acetylcholine receptor in PC12 cells (ganglionic)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50498044(CHEMBL3329529)
Affinity DataEC50:  750nMAssay Description:Agonist activity at human alpha6/alpha3beta2beta3 nAChR transfected in CHO cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Homo sapiens (Human))
Burnham Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50201053((1R,6S)-2-bromo-5-(3,8-diaza-bicyclo[4.2.0]oct-8-y...)
Affinity DataEC50:  794nMAssay Description:Agonist activity against human alpha3beta4 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Homo sapiens (Human))
Burnham Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50411220(CHEMBL465916)
Affinity DataEC50:  832nMAssay Description:Agonist activity against human alpha3beta4 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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