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Found 54 of ic50 for UniProtKB: P24008
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50334788((17beta-(N-tert-butylcarbamoyl)-4-aza-5alpha-andro...)
Affinity DataIC50:  4.20nMAssay Description:Compound was tested for the inhibitory activity against Steroid 5-alpha-reductase type 1 in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50334788((17beta-(N-tert-butylcarbamoyl)-4-aza-5alpha-andro...)
Affinity DataIC50:  10nMAssay Description:Inhibition of Steroid 5-alpha-reductase type I from rat ventral prostate (RVP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50517901(CHEMBL4540042)
Affinity DataIC50:  15nMAssay Description:Inhibition of type 1 5alpha reductase in rat prostateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50334788((17beta-(N-tert-butylcarbamoyl)-4-aza-5alpha-andro...)
Affinity DataIC50:  30nMAssay Description:Inhibition of type 1 5alpha reductase in rat prostateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50517880(CHEMBL4569322)
Affinity DataIC50:  34nMAssay Description:Inhibition of type 1 5alpha reductase in rat prostateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50043604((8S,9S,10R,13S,14S,17S)-17-(tert-butylcarbamoyl)-1...)
Affinity DataIC50:  45nMAssay Description:Inhibitory activity against rat Steroid 5-alpha-reductase type I using 18213 3H testosterone 210 nM as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50462940(CHEMBL4244937)
Affinity DataIC50:  290nMAssay Description:Inhibition of rat liver microsomal SRD5A1 incubated for 60 mins by thin layer chromatographyMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50462940(CHEMBL4244937)
Affinity DataIC50:  291nMAssay Description:Inhibition of rat liver microsomes 5alpha-reductase1 using [1,2,6,7-3H]T as substrate measured after 60 mins by chromatographic methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50589275(CHEMBL5190333)
Affinity DataIC50:  320nMAssay Description:Inhibition of rat liver microsomal SRD5A1 incubated for 60 mins by thin layer chromatographyMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50287684((4aR,6aS,7S)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7...)
Affinity DataIC50:  500nMAssay Description:Compound was tested for its inhibitory potency against rat Steroid 5-alpha-reductase type 1 expressed in transformed yeast Saccharomyces cerevesiaeMore data for this Ligand-Target Pair
In DepthDetails Article
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50116417(4-(1-Diphenylcarbamoyl-piperidin-4-ylidenemethyl)-...)
Affinity DataIC50:  540nMAssay Description:Inhibition of Steroid 5-alpha-reductase type I from rat ventral prostate (RVP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50116432(4-(1-Diphenylacetyl-piperidin-4-ylidenemethyl)-3-f...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of Steroid 5-alpha-reductase type I from rat ventral prostate (RVP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50180893((3-methyl-4-(4-phenoxybenzoyl)phenyl)acetic acid |...)
Affinity DataIC50:  1.45E+3nMpH: 6.6Assay Description:Displacement of [3H]-androstenedione from 5alpha reductase1 in rat ventral prostrate homogenate at pH 6.6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50116422(4-[1-(3,3-Diphenyl-propionyl)-piperidin-4-ylidenem...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of Steroid 5-alpha-reductase type I from rat ventral prostate (RVP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50116419(4-[1-(2,2-Dicyclohexyl-acetyl)-piperidin-4-ylidene...)
Affinity DataIC50:  1.80E+3nMAssay Description:In vitro inhibitory activity against steroid Steroid 5-alpha-reductase type I of rat ventral prostate (RVP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50116428(4-(1-Diphenylacetyl-piperidin-4-ylidenemethyl)-3-m...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of Steroid 5-alpha-reductase type I from rat ventral prostate (RVP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50032282(4-(2-{(E)-3-[1-(1-Propyl-butyl)-1H-indol-5-yl]-but...)
Affinity DataIC50:  2.30E+3nMAssay Description:5 alpha- reductase inhibitory activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50055147(4-{2-[(E)-3-(1-Benzhydryl-1H-indol-5-yl)-pent-2-en...)
Affinity DataIC50:  2.50E+3nMAssay Description:5 alpha- reductase inhibitory activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50116416(4-[1-(Adamantane-1-carbonyl)-piperidin-4-ylideneme...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of Steroid 5-alpha-reductase type I from rat ventral prostate (RVP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50116424(CHEMBL115438 | {4-[1-(2,2-Dicyclohexyl-acetyl)-pip...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of Steroid 5-alpha-reductase type I from rat ventral prostate (RVP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50055149(4-[2-((E)-3-{1-[Bis-(4-fluoro-phenyl)-methyl]-1H-i...)
Affinity DataIC50:  3.40E+3nMAssay Description:5 alpha- reductase inhibitory activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50116423(4-(1-Diphenylacetyl-piperidin-4-ylidenemethyl)-ben...)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of Steroid 5-alpha-reductase type I from rat ventral prostate (RVP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50055154(4-(2-{(E)-3-[1-(1-Propyl-pentyl)-1H-indol-5-yl]-pe...)
Affinity DataIC50:  3.60E+3nMAssay Description:5 alpha- reductase inhibitory activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50032281(4-(2-{(E)-3-[1-(1-Propyl-pentyl)-1H-indol-5-yl]-bu...)
Affinity DataIC50:  4.10E+3nMAssay Description:5 alpha- reductase inhibitory activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50116418(CHEMBL323856 | [4-(1-Diphenylacetyl-piperidin-4-yl...)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of Steroid 5-alpha-reductase type I from rat ventral prostate (RVP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50055146(4-(2-{(E)-3-[1-(1-Isobutyl-3-methyl-butyl)-1H-indo...)
Affinity DataIC50:  4.80E+3nMAssay Description:5 alpha- reductase inhibitory activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50055152(4-[2-((E)-3-{1-[Bis-(4-fluoro-phenyl)-methyl]-1H-i...)
Affinity DataIC50:  4.90E+3nMAssay Description:5 alpha- reductase inhibitory activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50032288(4-{2-[(E)-3-(1-Benzhydryl-1H-indol-5-yl)-but-2-eno...)
Affinity DataIC50:  5.60E+3nMAssay Description:5 alpha- reductase inhibitory activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50116426(4-[1-(Adamantane-1-carbonyl)-piperidin-4-ylideneme...)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of Steroid 5-alpha-reductase type I from rat ventral prostate (RVP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50032264(4-(2-{(E)-3-[1-(1-Isobutyl-3-methyl-butyl)-1H-indo...)
Affinity DataIC50:  8.00E+3nMAssay Description:5 alpha- reductase inhibitory activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50025356(4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10...)
Affinity DataIC50:  4.00E+4nMAssay Description:Compound was tested for its inhibitory potency against rat Steroid 5-alpha-reductase type 1 expressed in transformed yeast Saccharomyces cerevesiaeMore data for this Ligand-Target Pair
In DepthDetails Article
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50462939(CHEMBL4247033)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibition of rat liver microsomes 5alpha-reductase1 using [1,2,6,7-3H]T as substrate measured after 60 mins by chromatographic methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50032315(4-{2-[(E)-3-(1-Benzyl-1H-indol-5-yl)-but-2-enoylam...)
Affinity DataIC50:  5.00E+4nMAssay Description:5 alpha- reductase inhibitory activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50462938(CHEMBL4238710)
Affinity DataIC50:  8.30E+4nMAssay Description:Inhibition of rat liver microsomes 5alpha-reductase1 using [1,2,6,7-3H]T as substrate measured after 60 mins by chromatographic methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50135045(CHEMBL3735672)
Affinity DataIC50:  8.80E+4nMAssay Description:Inhibition of rat liver type 1 5alpha-reductase assessed as transformation of testosterone to dihydrotestosteroneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50102597(CHEMBL3342904)
Affinity DataIC50:  9.45E+4nMAssay Description:Inhibition of rat liver 5alpha-reductase type 1 assessed as conversion of [3H]testosterone to dihydrotestosteroneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50135092(CHEMBL3735149)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of rat liver type 1 5alpha-reductase assessed as transformation of testosterone to dihydrotestosteroneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50102596(CHEMBL3342903)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of rat liver 5alpha-reductase type 1 assessed as conversion of [3H]testosterone to dihydrotestosteroneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50055145(4-[2-((Z)-3-{1-[Bis-(4-fluoro-phenyl)-methyl]-1H-i...)
Affinity DataIC50:  1.00E+5nMAssay Description:5 alpha- reductase inhibitory activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50055153(4-{2-[(E)-3-(1-Benzyl-1H-indol-5-yl)-2-methyl-acry...)
Affinity DataIC50:  1.20E+5nMAssay Description:5 alpha- reductase inhibitory activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50046527(CHEMBL3309454)
Affinity DataIC50:  1.50E+5nMAssay Description:Inhibition of Sprague-Dawley rat liver steroid 5-alpha-reductase assessed as inhibition of testosterone conversion to dihydrotestosterone incubated f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50102570(CHEMBL3342897)
Affinity DataIC50:  2.00E+5nMAssay Description:Inhibition of rat liver 5alpha-reductase type 1 assessed as conversion of [3H]testosterone to dihydrotestosteroneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50102573(CHEMBL3342898)
Affinity DataIC50:  2.50E+5nMAssay Description:Inhibition of rat liver 5alpha-reductase type 1 assessed as conversion of [3H]testosterone to dihydrotestosteroneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50102584(CHEMBL3342899)
Affinity DataIC50:  2.65E+5nMAssay Description:Inhibition of rat liver 5alpha-reductase type 1 assessed as conversion of [3H]testosterone to dihydrotestosteroneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50102592(CHEMBL3342900)
Affinity DataIC50:  3.00E+5nMAssay Description:Inhibition of rat liver 5alpha-reductase type 1 assessed as conversion of [3H]testosterone to dihydrotestosteroneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50102598(CHEMBL3342905)
Affinity DataIC50:  3.00E+5nMAssay Description:Inhibition of rat liver 5alpha-reductase type 1 assessed as conversion of [3H]testosterone to dihydrotestosteroneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50102595(CHEMBL3342902)
Affinity DataIC50:  3.20E+5nMAssay Description:Inhibition of rat liver 5alpha-reductase type 1 assessed as conversion of [3H]testosterone to dihydrotestosteroneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50135090(CHEMBL3735678)
Affinity DataIC50:  3.20E+5nMAssay Description:Inhibition of rat liver type 1 5alpha-reductase assessed as transformation of testosterone to dihydrotestosteroneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50102593(CHEMBL3342901)
Affinity DataIC50:  3.20E+5nMAssay Description:Inhibition of rat liver 5alpha-reductase type 1 assessed as conversion of [3H]testosterone to dihydrotestosteroneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Kingston University

Curated by ChEMBL
LigandPNGBDBM50334788((17beta-(N-tert-butylcarbamoyl)-4-aza-5alpha-andro...)
Affinity DataIC50:  6.30E+5nMAssay Description:Inhibition of rat liver type 1 5alpha-reductase assessed as transformation of testosterone to dihydrotestosteroneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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