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TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 203365BDBM203365(US9242981, 110)
Affinity DataKd:  0.0300nMT: 2°CAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 203368BDBM203368(US9242981, 113)
Affinity DataKd:  0.0300nMT: 2°CAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 203378BDBM203378(US9242981, 123)
Affinity DataKd:  0.0600nMT: 2°CAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 203367BDBM203367(US9242981, 112)
Affinity DataKd:  0.120nMT: 2°CAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 203349BDBM203349(US9242981, 84)
Affinity DataKd:  0.130nMT: 2°CAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 203364BDBM203364(US9242981, 109)
Affinity DataKd:  0.140nMT: 2°CAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 203339BDBM203339(US9242981, 71)
Affinity DataKd:  0.150nMT: 2°CAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 203321BDBM203321(US9242981, 53)
Affinity DataKd:  0.150nMT: 2°CAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 203326BDBM203326(US9242981, 58)
Affinity DataKd:  0.25nMT: 2°CAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 203325BDBM203325(US9242981, 57)
Affinity DataKd:  0.300nMT: 2°CAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 203337BDBM203337(US9242981, 69)
Affinity DataKd:  0.310nMT: 2°CAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 203319BDBM203319(US9242981, 48)
Affinity DataKd:  0.370nMT: 2°CAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 203355BDBM203355(US9242981, 100)
Affinity DataKd:  0.400nMT: 2°CAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 203329BDBM203329(US9242981, 61)
Affinity DataKd:  0.470nMT: 2°CAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 203322BDBM203322(US9242981, 54)
Affinity DataKd:  0.510nMT: 2°CAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 203317BDBM203317(US9242981, 46)
Affinity DataKd:  0.700nMT: 2°CAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 203328BDBM203328(US9242981, 60)
Affinity DataKd:  1.12nMT: 2°CAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 203343BDBM203343(US9242981, 75)
Affinity DataKd:  1.36nMT: 2°CAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 203327BDBM203327(US9242981, 59)
Affinity DataKd:  1.51nMT: 2°CAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 203344BDBM203344(US9242981, 76)
Affinity DataKd:  1.55nMT: 2°CAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 203330BDBM203330(US9242981, 62)
Affinity DataKd:  2.10nMT: 2°CAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 203308BDBM203308(US9242981, 37)
Affinity DataKd:  6nMT: 2°CAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 176676BDBM176676(US9115122, 2.3.2)
Affinity DataKd:  130nMAssay Description:CADD and biological testing to identify compounds that interact with novel ERK substrate docking sites. The known ERK2 docking sites include the DRS ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 176678BDBM176678(US9115122, SF-2-054)
Affinity DataKd:  170nMAssay Description:CADD and biological testing to identify compounds that interact with novel ERK substrate docking sites. The known ERK2 docking sites include the DRS ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 176678BDBM176678(US9115122, SF-2-054)
Affinity DataKd:  400nMAssay Description:CADD and biological testing to identify compounds that interact with novel ERK substrate docking sites. The known ERK2 docking sites include the DRS ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 176677BDBM176677(US9115122, SF-2-062)
Affinity DataKd:  1.30E+3nMAssay Description:CADD and biological testing to identify compounds that interact with novel ERK substrate docking sites. The known ERK2 docking sites include the DRS ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 176678BDBM176678(US9115122, SF-2-054)
Affinity DataKd:  1.40E+3nMAssay Description:CADD and biological testing to identify compounds that interact with novel ERK substrate docking sites. The known ERK2 docking sites include the DRS ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 176674BDBM176674(US9115122, 76.3)
Affinity DataKd:  1.50E+3nMAssay Description:CADD and biological testing to identify compounds that interact with novel ERK substrate docking sites. The known ERK2 docking sites include the DRS ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 176675BDBM176675(US9115122, 76.4)
Affinity DataKd:  2.40E+3nMAssay Description:CADD and biological testing to identify compounds that interact with novel ERK substrate docking sites. The known ERK2 docking sites include the DRS ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 176673BDBM176673(US9115122, 76.2)
Affinity DataKd:  3.30E+3nMAssay Description:CADD and biological testing to identify compounds that interact with novel ERK substrate docking sites. The known ERK2 docking sites include the DRS ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 176677BDBM176677(US9115122, SF-2-062)
Affinity DataKd:  3.70E+3nMAssay Description:CADD and biological testing to identify compounds that interact with novel ERK substrate docking sites. The known ERK2 docking sites include the DRS ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 176672BDBM176672(US9115122, 76)
Affinity DataKd:  5.00E+3nMAssay Description:CADD and biological testing to identify compounds that interact with novel ERK substrate docking sites. The known ERK2 docking sites include the DRS ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 176677BDBM176677(US9115122, SF-2-062)
Affinity DataKd:  6.00E+3nMAssay Description:CADD and biological testing to identify compounds that interact with novel ERK substrate docking sites. The known ERK2 docking sites include the DRS ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 176677BDBM176677(US9115122, SF-2-062)
Affinity DataKd:  6.80E+3nMAssay Description:CADD and biological testing to identify compounds that interact with novel ERK substrate docking sites. The known ERK2 docking sites include the DRS ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 176679BDBM176679(US9115122, SS-1-019)
Affinity DataKd:  9.30E+3nMAssay Description:CADD and biological testing to identify compounds that interact with novel ERK substrate docking sites. The known ERK2 docking sites include the DRS ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Mouse)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 176678BDBM176678(US9115122, SF-2-054)
Affinity DataKd:  1.02E+4nMAssay Description:CADD and biological testing to identify compounds that interact with novel ERK substrate docking sites. The known ERK2 docking sites include the DRS ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
US Patent