Compile Data Set for Download or QSAR
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Found 231 of ic50 for UniProtKB: P49286
TargetMelatonin receptor type 1A/1B(Homo sapiens (Human))
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandPNGBDBM50230659(CHEMBL37549)
Affinity DataIC50:  0.0000500nMAssay Description:Monophasic inhibitory concentration against melatonin receptor was measured on ovine pars tuberalis membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1A/1B(Homo sapiens (Human))
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandPNGBDBM50470001(CHEMBL322339)
Affinity DataIC50: <0.00100nMAssay Description:Monophasic inhibitory concentration against melatonin receptor was measured on ovine pars tuberalis membrane.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1A/1B(Homo sapiens (Human))
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandPNGBDBM50470007(CHEMBL322269)
Affinity DataIC50:  0.00118nMAssay Description:Monophasic inhibitory concentration against melatonin receptor was measured on ovine pars tuberalis membrane.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1A/1B(Homo sapiens (Human))
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandPNGBDBM50230657(CHEMBL290493)
Affinity DataIC50:  0.00345nMAssay Description:Monophasic inhibitory concentration against melatonin receptor was measured on ovine pars tuberalis membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1A/1B(Homo sapiens (Human))
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandPNGBDBM29611(2-Iodomelatonin | CHEMBL289233 | Melatonin,2-Iodo)
Affinity DataIC50:  0.00500nMAssay Description:Inhibition of 2-[125I]iodomelatonin stimulated calcium dependent dopamine release from the rabbit retina.More data for this Ligand-Target Pair
TargetMelatonin receptor type 1A/1B(Homo sapiens (Human))
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandPNGBDBM50231291(CHEMBL421013)
Affinity DataIC50:  0.0100nMAssay Description:Inhibition of 2-[125I]iodomelatonin stimulated calcium dependent dopamine release from the rabbit retina.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1A/1B(Homo sapiens (Human))
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandPNGBDBM50469993(CHEMBL320267)
Affinity DataIC50:  0.0153nMAssay Description:Monophasic inhibitory concentration against melatonin receptor was measured on ovine pars tuberalis membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1A/1B(Homo sapiens (Human))
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | Melatonin | N-[2-(5-methoxy-1H-indol-3-...)
Affinity DataIC50:  0.0170nMAssay Description:Inhibition of 2-[125I]iodomelatonin stimulated calcium dependent dopamine release from the rabbit retina.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMelatonin receptor type 1A/1B(Homo sapiens (Human))
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandPNGBDBM50043289(CHEMBL34730 | N-[2-(6-Chloro-5-methoxy-1H-indol-3-...)
Affinity DataIC50:  0.0400nMAssay Description:Inhibition of 2-[125I]iodomelatonin stimulated calcium dependent dopamine release from the rabbit retina.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM103446(US8552037, 93)
Affinity DataIC50:  0.0490nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMelatonin receptor type 1A/1B(Homo sapiens (Human))
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandPNGBDBM50471125(CHEMBL433237)
Affinity DataIC50:  0.0520nMAssay Description:Inhibitory activity against melatonin receptor in the quail optica tecta using 2-[125] iodomelatonin as labelled ligandMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1A/1B(Homo sapiens (Human))
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandPNGBDBM50034110(CHEMBL15060 | Melatonin,2-Phenyl | N-[2-(5-Methoxy...)
Affinity DataIC50:  0.0620nMAssay Description:Inhibitory activity against melatonin receptor in the quail optica tecta using 2-[125] iodomelatonin as labelled ligandMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1A/1B(Homo sapiens (Human))
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandPNGBDBM50034110(CHEMBL15060 | Melatonin,2-Phenyl | N-[2-(5-Methoxy...)
Affinity DataIC50:  0.0620nMAssay Description:Inhibitory activity against melatonin receptor in the quail optica tecta using 2-[125] iodomelatonin as radiolabeled ligandMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1A/1B(Homo sapiens (Human))
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandPNGBDBM50231292(CHEMBL95920)
Affinity DataIC50:  0.0630nMAssay Description:Inhibition of 2-[125I]iodomelatonin stimulated calcium dependent dopamine release from the rabbit retina.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1A/1B(Homo sapiens (Human))
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandPNGBDBM50035179(Agomelatine | CHEMBL10878 | N-[2-(7-Methoxy-naphth...)
Affinity DataIC50:  0.0761nMAssay Description:Monophasic inhibitory concentration against melatonin receptor was measured on ovine pars tuberalis membrane.More data for this Ligand-Target Pair
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM103448(US8552037, 95)
Affinity DataIC50:  0.0910nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM103450(US8552037, 98)
Affinity DataIC50:  0.120nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMelatonin receptor type 1A/1B(Homo sapiens (Human))
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandPNGBDBM50043287(CHEMBL33415 | Melatonin,2-Bromo | N-[2-(2-Bromo-5-...)
Affinity DataIC50:  0.130nMAssay Description:Inhibitory activity against melatonin receptor in the quail optica tecta using 2-[125] iodomelatonin as radiolabeled ligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM103443(US8552037, 90)
Affinity DataIC50:  0.130nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMelatonin receptor type 1A/1B(Homo sapiens (Human))
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandPNGBDBM50043287(CHEMBL33415 | Melatonin,2-Bromo | N-[2-(2-Bromo-5-...)
Affinity DataIC50:  0.130nMAssay Description:Inhibitory activity against melatonin receptor in the quail optica tecta using 2-[125] iodomelatonin as labelled ligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM103456(US8552037, 123)
Affinity DataIC50:  0.140nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMelatonin receptor type 1A/1B(Homo sapiens (Human))
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | Melatonin | N-[2-(5-methoxy-1H-indol-3-...)
Affinity DataIC50:  0.157nMAssay Description:Monophasic inhibitory concentration against melatonin receptor was measured on ovine pars tuberalis membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMelatonin receptor type 1A/1B(Homo sapiens (Human))
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandPNGBDBM50471136(CHEMBL33006)
Affinity DataIC50:  0.160nMAssay Description:Inhibitory activity against melatonin receptor in the quail optica tecta using 2-[125] iodomelatonin as labelled ligandMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1A/1B(Homo sapiens (Human))
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandPNGBDBM50471125(CHEMBL433237)
Affinity DataIC50:  0.189nMAssay Description:Agonist activity against melatonin receptor was tested in the absence of iodomelatoninMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM103440(US8552037, 86)
Affinity DataIC50:  0.220nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM103438(US8552037, 83)
Affinity DataIC50:  0.220nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM103437(US8552037, 82)
Affinity DataIC50:  0.240nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM103445(US8552037, 92)
Affinity DataIC50:  0.280nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM103449(US8552037, 97)
Affinity DataIC50:  0.280nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM103454(US8552037, 116)
Affinity DataIC50:  0.280nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM9019(CHEMBL45 | Melatonin | N-[2-(5-methoxy-1H-indol-3-...)
Affinity DataIC50:  0.300nMAssay Description:In vitro receptor binding at MT2 (Melatonin) receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMelatonin receptor type 1B(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM103441(US8552037, 87)
Affinity DataIC50:  0.310nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM103442(US8552037, 89)
Affinity DataIC50:  0.310nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM103436(US8552037, 81)
Affinity DataIC50:  0.370nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM103452(US8552037, 100)
Affinity DataIC50:  0.410nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM103439(US8552037, 84)
Affinity DataIC50:  0.430nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMelatonin receptor type 1A/1B(Homo sapiens (Human))
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandPNGBDBM50045843(8-M-PDOT | CHEMBL99377 | N-(8-Methoxy-1,2,3,4-tetr...)
Affinity DataIC50:  0.480nMAssay Description:Inhibition of 2-[125I]iodomelatonin stimulated calcium dependent dopamine release from the rabbit retina.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM9019(CHEMBL45 | Melatonin | N-[2-(5-methoxy-1H-indol-3-...)
Affinity DataIC50:  0.530nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMelatonin receptor type 1B(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM9019(CHEMBL45 | Melatonin | N-[2-(5-methoxy-1H-indol-3-...)
Affinity DataIC50:  0.530nMAssay Description:Binding affinity to human MT2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMelatonin receptor type 1A/1B(Homo sapiens (Human))
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandPNGBDBM50471833(CHEMBL127337)
Affinity DataIC50:  0.654nMAssay Description:inhibitory concentration against Melatonin receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50037242(CHEMBL323332 | N-(2-(5-methoxybenzofuran-3-yl)ethy...)
Affinity DataIC50:  0.700nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM103453(US8552037, 107)
Affinity DataIC50:  0.75nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM103455(US8552037, 121)
Affinity DataIC50:  0.770nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMelatonin receptor type 1A/1B(Homo sapiens (Human))
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandPNGBDBM50471127(CHEMBL62088)
Affinity DataIC50:  0.830nMAssay Description:Inhibitory activity against melatonin receptor in the quail optica tecta using 2-[125] iodomelatonin as labelled ligandMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50342770(CHEMBL456727 | N-(2-(7-(methylthio)naphthalen-1-yl...)
Affinity DataIC50:  0.955nMAssay Description:Binding affinity to human MT2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1A/1B(Homo sapiens (Human))
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandPNGBDBM50037253(2-Iodo-N-[2-(5-methoxy-1H-indol-3-yl)-ethyl]-aceta...)
Affinity DataIC50:  0.980nMAssay Description:Monophasic inhibitory concentration against melatonin receptor was measured on ovine pars tuberalis membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1A/1B(Homo sapiens (Human))
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandPNGBDBM50231298(CHEMBL330385)
Affinity DataIC50:  1nMAssay Description:Inhibition of 2-[125I]iodomelatonin stimulated calcium dependent dopamine release from the rabbit retina.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1A/1B(Homo sapiens (Human))
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandPNGBDBM50471112(CHEMBL61991)
Affinity DataIC50:  1.10nMAssay Description:Inhibitory activity against melatonin receptor of quail optica tecta with 200 pM 2-[125] iodomelatoninMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1A/1B(Homo sapiens (Human))
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandPNGBDBM50037219(CHEMBL109235 | N-[2-(5-Methoxy-benzo[b]thiophen-3-...)
Affinity DataIC50:  1.20nMAssay Description:Monophasic inhibitory concentration against melatonin receptor was measured on ovine pars tuberalis membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1A/1B(Homo sapiens (Human))
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandPNGBDBM50471125(CHEMBL433237)
Affinity DataIC50:  1.20nMAssay Description:Agonist activity against melatonin receptor in the presence of iodomelatoninMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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