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Report error Found 34 of ic50 for UniProtKB: Q9Y6F1
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50306253(1-(2-(pyridin-3-yl)acetyl)-2,3,9,9a-tetrahydro-1H-...)
Affinity DataIC50:  50nMAssay Description:Inhibition of PARP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM206061(US9255106, S3)
Affinity DataIC50:  66.9nMAssay Description:In order to test the selectivity of substituents on piperazinotriazole ring within the PARP family, the selectivity of compound S3 and positive compo...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50306256(1-(3-(pyrazin-2-yl)propanoyl)-2,3,9,9a-tetrahydro-...)
Affinity DataIC50:  70nMAssay Description:Inhibition of PARP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50:  320nMAssay Description:In order to test the selectivity of substituents on piperazinotriazole ring within the PARP family, the selectivity of compound S3 and positive compo...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM103558(ME0328)
Affinity DataIC50:  890nMAssay Description:Experiments todetermine IC50 values were conducted with compound concentrationsin the range between 10 nM and 450 μM with a DMSO concentrationof...More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM103558(ME0328)
Affinity DataIC50:  900nMAssay Description:Inhibition of full length ATRD3 (unknown origin)More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50444033(CHEMBL3092553)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of full length ATRD3 (unknown origin)More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM103556(ME0355)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of full length ATRD3 (unknown origin)More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50316226((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of human PARP3 by trichloroacetic acid precipitation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM103556(ME0355)
Affinity DataIC50:  1.30E+3nMAssay Description:Experiments todetermine IC50 values were conducted with compound concentrationsin the range between 10 nM and 450 μM with a DMSO concentrationof...More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50444034(CHEMBL3092544)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of full length ATRD3 (unknown origin)More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50444027(CHEMBL3092523)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of full length ATRD3 (unknown origin)More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50444028(CHEMBL3092522)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of full length ATRD3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM103554(STO1131 | US8551988, 39)
Affinity DataIC50:  6.00E+3nMAssay Description:Experiments todetermine IC50 values were conducted with compound concentrationsin the range between 10 nM and 450 μM with a DMSO concentrationof...More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50444029(CHEMBL3092521)
Affinity DataIC50:  9.60E+3nMAssay Description:Inhibition of full length ATRD3 (unknown origin)More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50434127(CHEMBL2381633)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PARP3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50434157(CHEMBL2381958 | US9340549, 78)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PARP3 (unknown origin) using histone as substrate after 1 hr by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50318567(2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PARP3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50444030(CHEMBL3092520)
Affinity DataIC50:  1.11E+4nMAssay Description:Inhibition of full length ATRD3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50104286(CHEMBL3593715)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of full-length human ARTD3 using 500 nM NAD substrate after 1 hrs incubationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50444031(CHEMBL3092518)
Affinity DataIC50:  1.32E+4nMAssay Description:Inhibition of full length ATRD3 (unknown origin)More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50444032(CHEMBL3092517)
Affinity DataIC50:  1.44E+4nMAssay Description:Inhibition of full length ATRD3 (unknown origin)More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM103557(ME0327)
Affinity DataIC50:  1.52E+4nMAssay Description:Inhibition of full length ATRD3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM103557(ME0327)
Affinity DataIC50:  1.53E+4nMAssay Description:Experiments todetermine IC50 values were conducted with compound concentrationsin the range between 10 nM and 450 μM with a DMSO concentrationof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50104288(CHEMBL3594137)
Affinity DataIC50:  3.40E+4nMAssay Description:Inhibition of full-length human ARTD3 using 500 nM NAD substrate after 1 hrs incubationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50104287(CHEMBL3594136)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of full-length human ARTD3 using 500 nM NAD substrate after 1 hrs incubationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50104285(CHEMBL3593716)
Affinity DataIC50:  9.10E+4nMAssay Description:Inhibition of full-length human ARTD3 using 500 nM NAD substrate after 1 hrs incubationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50136755(CHEMBL3752386)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human ARTD3 by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM103555(ME0354)
Affinity DataIC50: >1.00E+5nMAssay Description:Experiments todetermine IC50 values were conducted with compound concentrationsin the range between 10 nM and 450 μM with a DMSO concentrationof...More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM103555(ME0354)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of full length ATRD3 (unknown origin)More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50444036(CHEMBL3092540)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of full length ATRD3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50136772(CHEMBL3752492)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human ARTD3 by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM199181(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Affinity DataIC50: >1.00E+5nMAssay Description:This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50444035(CHEMBL3092541)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of full length ATRD3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed