Affinity DataIC50: 2.70nMAssay Description:Receptor binding affinity was determined in a radioligand binding assay against [125I]ET1 with recombinant human ETA receptor, expressed in baculovir...More data for this Ligand-Target Pair
Affinity DataIC50: 4.60nMAssay Description:Inhibition of [3H]-Flumazenil binding to recombinant GABA-A receptor alpha-5 subunit in spinal cordMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Binding affinity to human recombinant GABAA alpha5beta3gamma2 expressed in Xenopous laevis oocytes by patch clamp techniqueMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-2(Homo sapiens (Human))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataIC50: 51nMAssay Description:Antagonist activity at human alpha5beta2gamma2 GABAA receptor expressed in HEK cells by FMP assayMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:The compounds are tested on HEK-293 (Human Embryonic Kidney) cells stably expressing the subunit α5 of the human GABAA receptor, and also the su...More data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:The compounds are tested on HEK-293 (Human Embryonic Kidney) cells stably expressing the subunit α5 of the human GABAA receptor, and also the su...More data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of GABAA alpha5 receptor (unknown origin)More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 200nMAssay Description:The compounds are tested on HEK-293 (Human Embryonic Kidney) cells stably expressing the subunit α5 of the human GABAA receptor, and also the su...More data for this Ligand-Target Pair
Affinity DataIC50: 201nMAssay Description:Antagonist activity at human GABA-A alpha5 receptor expressed in HEK293 cell membranes assessed as inhibition of GABA-induced response preincubated f...More data for this Ligand-Target Pair
Affinity DataIC50: 210nMAssay Description:Displacement of [3H]Ro15-4513 from GABAA alpha-5-beta-2-gamma-2 receptor expressed in Sf9 baculovirus systemMore data for this Ligand-Target Pair
Affinity DataIC50: 240nMAssay Description:Inhibition of GABAA alpha5 receptor (unknown origin)More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 250nMAssay Description:The compounds are tested on HEK-293 (Human Embryonic Kidney) cells stably expressing the subunit α5 of the human GABAA receptor, and also the su...More data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:The compounds are tested on HEK-293 (Human Embryonic Kidney) cells stably expressing the subunit α5 of the human GABAA receptor, and also the su...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-2(Homo sapiens (Human))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataIC50: 537nMAssay Description:Antagonist activity at human alpha5beta2gamma2 GABAA receptor expressed in HEK293 cells by FMP assayMore data for this Ligand-Target Pair
Affinity DataIC50: 550nMAssay Description:Displacement of [3H]Ro15-4513 from GABAA alpha-5-beta-2-gamma-2 receptor expressed in Sf9 baculovirus systemMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-2(Homo sapiens (Human))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataIC50: 589nMAssay Description:Antagonist activity at human alpha5beta2gamma2 GABAA receptor expressed in HEK cells by FMP assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human recombinant GABAA alpha5 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [3H]Ro15-4513 from GABAA alpha-5-beta-2-gamma-2 receptor expressed in Sf9 baculovirus systemMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-2(Homo sapiens (Human))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataIC50: 1.45E+3nMAssay Description:Antagonist activity at human alpha5beta2gamma2 GABAA receptor expressed in HEK293 cells by FMP assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]Ro15-4513 from GABAA alpha-5-beta-2-gamma-2 receptor expressed in Sf9 baculovirus systemMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]Ro15-4513 from GABAA alpha-5-beta-2-gamma-2 receptor expressed in Sf9 baculovirus systemMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]Ro15-4513 from GABAA alpha-5-beta-2-gamma-2 receptor expressed in Sf9 baculovirus systemMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]Ro15-4513 from GABAA alpha-5-beta-2-gamma-2 receptor expressed in Sf9 baculovirus systemMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]Ro15-4513 from GABAA alpha-5-beta-2-gamma-2 receptor expressed in Sf9 baculovirus systemMore data for this Ligand-Target Pair
Affinity DataIC50: 1.94E+4nMAssay Description:Negative allosteric modulation activity at human GABAA alpha5beta3gamma2 stably expressed in HEK cells by patch clamp methodMore data for this Ligand-Target Pair