Compile Data Set for Download or QSAR
maximum 50k data
Found 25 of ic50 for UniProtKB: P31644
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290077(CHEMBL73416 | N-[2-(4-Chloro-phenyl)-imidazo[1,2-a...)
Affinity DataIC50:  2.70nMAssay Description:Receptor binding affinity was determined in a radioligand binding assay against [125I]ET1 with recombinant human ETA receptor, expressed in baculovir...More data for this Ligand-Target Pair
In DepthDetails Article
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290077(CHEMBL73416 | N-[2-(4-Chloro-phenyl)-imidazo[1,2-a...)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of [3H]-Flumazenil binding to recombinant GABA-A receptor alpha-5 subunit in spinal cordMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)
Affinity DataIC50:  17nMAssay Description:Binding affinity to human recombinant GABAA alpha5beta3gamma2 expressed in Xenopous laevis oocytes by patch clamp techniqueMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-2(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50588336(CHEMBL5186739)
Affinity DataIC50:  51nMAssay Description:Antagonist activity at human alpha5beta2gamma2 GABAA receptor expressed in HEK cells by FMP assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM126721(US8778932, 36)
Affinity DataIC50:  100nMAssay Description:The compounds are tested on HEK-293 (Human Embryonic Kidney) cells stably expressing the subunit α5 of the human GABAA receptor, and also the su...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM126717(US8778932, 6)
Affinity DataIC50:  130nMAssay Description:The compounds are tested on HEK-293 (Human Embryonic Kidney) cells stably expressing the subunit α5 of the human GABAA receptor, and also the su...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50608946(CHEMBL2008708)
Affinity DataIC50:  200nMAssay Description:Inhibition of GABAA alpha5 receptor (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM126719(US8778932, 21)
Affinity DataIC50:  200nMAssay Description:The compounds are tested on HEK-293 (Human Embryonic Kidney) cells stably expressing the subunit α5 of the human GABAA receptor, and also the su...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM126720(US8778932, 31)
Affinity DataIC50:  201nMAssay Description:Antagonist activity at human GABA-A alpha5 receptor expressed in HEK293 cell membranes assessed as inhibition of GABA-induced response preincubated f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50244154(1-(4-chlorobenzoyl)-6,6-dimethyl-3-(methylthio)-he...)
Affinity DataIC50:  210nMAssay Description:Displacement of [3H]Ro15-4513 from GABAA alpha-5-beta-2-gamma-2 receptor expressed in Sf9 baculovirus systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50608947(CHEMBL5281056)
Affinity DataIC50:  240nMAssay Description:Inhibition of GABAA alpha5 receptor (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM126718(US8778932, 9)
Affinity DataIC50:  250nMAssay Description:The compounds are tested on HEK-293 (Human Embryonic Kidney) cells stably expressing the subunit α5 of the human GABAA receptor, and also the su...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM126720(US8778932, 31)
Affinity DataIC50:  500nMAssay Description:The compounds are tested on HEK-293 (Human Embryonic Kidney) cells stably expressing the subunit α5 of the human GABAA receptor, and also the su...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-2(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50588339(CHEMBL5187612)
Affinity DataIC50:  537nMAssay Description:Antagonist activity at human alpha5beta2gamma2 GABAA receptor expressed in HEK293 cells by FMP assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50244155(1-(4-chlorobenzoyl)-3-(methylthio)-hexahydrobenzo[...)
Affinity DataIC50:  550nMAssay Description:Displacement of [3H]Ro15-4513 from GABAA alpha-5-beta-2-gamma-2 receptor expressed in Sf9 baculovirus systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-2(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50588337(CHEMBL5177970)
Affinity DataIC50:  589nMAssay Description:Antagonist activity at human alpha5beta2gamma2 GABAA receptor expressed in HEK cells by FMP assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50329649(1-phenylethyl 9H-pyrido[3,4-b]indole-3-carboxylate...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human recombinant GABAA alpha5 receptorMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50244192((3-aminobenzo[b]thiophen-2-yl)(4-chlorophenyl)meth...)
Affinity DataIC50:  1.00E+3nMAssay Description:Displacement of [3H]Ro15-4513 from GABAA alpha-5-beta-2-gamma-2 receptor expressed in Sf9 baculovirus systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-2(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50588340(CHEMBL5204910)
Affinity DataIC50:  1.45E+3nMAssay Description:Antagonist activity at human alpha5beta2gamma2 GABAA receptor expressed in HEK293 cells by FMP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50019266(1-Methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepi...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]Ro15-4513 from GABAA alpha-5-beta-2-gamma-2 receptor expressed in Sf9 baculovirus systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50184953(A-33903 | CHEMBL204738 | N-(2-oxo-5-phenyl-2,3-dih...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]Ro15-4513 from GABAA alpha-5-beta-2-gamma-2 receptor expressed in Sf9 baculovirus systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50244193(4-bromo-3,5-dimethyl-1-((4-(3-nitrophenyl)thiazol-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]Ro15-4513 from GABAA alpha-5-beta-2-gamma-2 receptor expressed in Sf9 baculovirus systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50244156(6,6-dimethyl-3-(methylthio)-1-(3-nitrobenzoyl)-hex...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]Ro15-4513 from GABAA alpha-5-beta-2-gamma-2 receptor expressed in Sf9 baculovirus systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50244157(CHEMBL458317 | N-(4-chlorophenyl)-5-(2-(methylthio...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]Ro15-4513 from GABAA alpha-5-beta-2-gamma-2 receptor expressed in Sf9 baculovirus systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50580362(CHEMBL5086854)
Affinity DataIC50:  1.94E+4nMAssay Description:Negative allosteric modulation activity at human GABAA alpha5beta3gamma2 stably expressed in HEK cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed